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Chronic stress is associated with hippocampal atrophy and cognitive dysfunction. This study investigates how long-lasting administration of corticosterone as a mimic of experimentally induced stress affects psychometric performance and the expression of the phosphatidylethanolamine binding protein (PEBP1) in the adult hippocampus of one-year-old male rats. Psychometric investigations were conducted in rats before and after corticosterone treatment using a holeboard test system. Rats were randomly attributed to 2 groups (n = 7) for daily subcutaneous injection of either 26.8 mg/kg body weight corticosterone or sesame oil (vehicle control). Treatment was continued for 60 days, followed by cognitive retesting in the holeboard system. For protein analysis, the hippocampal proteome was separated by 2D electrophoresis (2DE) followed by image processing, statistical analysis, protein identification via peptide mass fingerprinting and gel matching and subsequent functional network mapping and molecular pathway analysis. Differential expression of PEBP1 was additionally quantified by Western blot analysis. Results show that chronic corticosterone significantly decreased rat hippocampal PEBP1 expression and induced a working and reference memory dysfunction. From this, we derive the preliminary hypothesis that PEBP1 may be a novel molecular mediator influencing cognitive integrity during chronic corticosterone exposure in rat hippocampus.  相似文献   
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While negative correlations have often been found between a respondent's education and his attitudes towards foreigners, the reasons for this education effect are still under debate. We examined the hypothesis that the highly educated may not be genuinely less xenophobic, but simply more prone to give socially desirable, xenophile answers in attitude questionnaires. We therefore compared the attitudes of respondents who were either questioned directly or using a cheating detection extension of the randomized‐response technique (RRT). The latter is supposed to yield more honest answers to sensitive questions by experimentally offering the interviewee a higher degree of confidentiality. Under direct questioning conditions, we replicated the education effect; 75% of the highly educated expressed xenophile attitudes, as opposed to only 55% of the less educated. Under randomized‐response conditions, we obtained significantly reduced estimates of 53% for the proportion of xenophiles among the highly educated, and 24% among the less educated, indicating a strong distortion of self‐reported attitudes towards foreigners in both groups. However, a significant proportion of participants disobeyed the RRT instructions regardless of education. Because the education effect was found even after controlling for social desirability, it seems to be a genuine effect, rather than an artefact of a differential response bias. Copyright © 2008 John Wiley & Sons, Ltd.  相似文献   
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Covert shifts of attention are usually reflected in RT differences between responses to valid and invalid cues in the Posner spatial attention task. Such inferences about covert shifts of attention do not control for microsaccades in the cue-target interval. We analyzed the effects of microsaccade orientation on RTs in four conditions, crossing peripheral visual and auditory cues with peripheral visual and auditory discrimination targets. Reaction time was generally faster on trials without microsaccades in the cue-target interval. If microsaccades occurred, the target-location congruency of the last microsaccade in the cue-target interval interacted in a complex way with cue validity. For valid visual cues, irrespective of whether the discrimination target was visual or auditory, target-congruent microsaccades delayed RT. For invalid cues, target-incongruent microsaccades facilitated RTs for visual target discrimination but delayed RT for auditory target discrimination. No reliable effects on RT were associated with auditory cues or with the first microsaccade in the cue-target interval. We discuss theoretical implications on the relation about spatial attention and oculomotor processes.  相似文献   
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The aim of the present research was to demonstrate that acquisitive self‐presentation in personality scales is not a barrier to their criterion‐related validities in human resource contexts, but rather a means to improve them. A pilot study (Study 1) with 96 job incumbents provided preliminary positive evidence. In Study 2, in the experimental group (n=99), the instructions asked job incumbents to work on a Big‐Five personality inventory (BFI‐K) as if they took part in a personnel selection procedure for a personally very attractive position. In the control group (n=93) of Study 2, job incumbents were asked to answer the inventory items honestly. As expected, the correlation between the self‐ratings of the motive to get along (i.e., which comprises emotional stability, conscientiousness, and agreeableness) and contextual performance assessments was significantly higher in the experimental group than in the control group in Study 2. Additionally, the correlation between the self‐ratings of the motive to get ahead (i.e., which comprises extraversion and openness to experience) and task performance and leadership assessments was significantly higher in the experimental group than in the control group in Study 2. It is proposed that responding to a personality inventory in a human resource decision situation should be conceptualized as a workplace simulation.  相似文献   
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A passive oddball experiment was used in which stimuli were emotional exclamations differing in their affective tone. In both electroencephalography (EEG) and magnetoencephalography (MEG), deviants elicited an N300 component, sometimes accompanied by a slow wave. Both components had a symmetrical distribution, but the former was more posterior than the latter. The same responses to prosodic stimuli were significant in 6 of 27 patients with severe disorders of consciousness (persistent vegetative state and minimally conscious state) and in all 3 of the examined locked-in patients, indicating that the procedure can be applied for testing neurological patients. The occurrence of significant responses depended on the presence or absence of a lesion to the right temporal lobe. Obviously, the N300 depends on the activity of the right temporal cortex but does not originate there. We suggest that the component is related not to the recognition of affective prosody as such, but to the following detection of affective mismatch due to violations of emotional context of stimulation.  相似文献   
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Preview benefit and parafoveal-on-foveal effects from word n + 2   总被引:2,自引:0,他引:2  
Using the gaze-contingent boundary paradigm with the boundary placed after word n, the experiment manipulated preview of word n + 2 for fixations on word n. There was no preview benefit for 1st-pass reading on word n + 2, replicating the results of K. Rayner, B. J. Juhasz, and S. J. Brown (2007), but there was a preview benefit on the 3-letter word n + 1, that is, after the boundary but before word n + 2. Additionally, both word n + 1 and word n + 2 exhibited parafoveal-on-foveal effects on word n. Thus, during a fixation on word n and given a short word n + 1, some information is extracted from word n + 2, supporting the hypothesis of distributed processing in the perceptual span.  相似文献   
220.
Although online dating has become an important strategy in finding a romantic partner, academic research into the antecedents of online dating is still scarce. The aim of this study was to investigate (a) the demographic predictors of online dating and (b) the validity of two opposite hypotheses that explain users' tendency to use the Internet for online dating: the social compensation and the rich-get-richer hypotheses. We presented 367 single Dutch Internet users between 18 and 60 years old with an online questionnaire. We found that online dating was unrelated to income and educational level. Respondents between 30 and 50 years old were the most active online daters. In support of the rich-get-richer hypothesis, people low in dating anxiety were more active online daters than people high in dating anxiety.  相似文献   
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