Inhibition as a "slave" process: deactivation of conditioned inhibition through extinction of conditioned excitation

Rats were used in a conditioned-suppression paradigm to investigate why a conditioned inhibition (CS-) does not extinguish when presented alone. Experiment 1 assessed the role of blocking by excitatory contextual cues and/or an evoked representation of the conditioned excitor (CS+), which had been nonreinforced in compound with the CS-. When the CS+ and context were extinguished prior to presentations of the CS- alone, the CS- showed a retardation effect, evidently reflecting latent inhibition, because no inhibition was detected in controls for which presentations of the CS- alone had been omitted. Experiment 2 showed that the loss of conditioned inhibition (CI) was due to excitatory extinction and not to time since conditioning. Furthermore, when excitation was reconditioned to the extinguished CS+ (Experiment 1), or to a novel CS in the same context (Experiment 2), CI was restored. Two other experiments evaluated whether the maintenance of CI depended upon excitation that was generic in form or associatively tied to the training context. They showed no loss of CI when groups received CS+ extinction in that context, along with concomitant presentations in a different context of the US by itself, for a novel CS, or correlated either positively or negatively with the original CS+. Collectively, the findings argue that CI is a "slave" to excitation, for when excitation is extinguished, CI is deactivated; and yet when excitation is reconditioned to the original or a new CS+ in the same or a different context, CI is restored.     

Positive affect as a moderator of liking effects on trust and attraction

Attitude similarity effects on attraction appear to be mediated sequentially by positive affect, inferred attraction, and trust. That is, the first two supposedly distal mediators influence each other in building trust, a mediator proximal to attraction. However, the correlational nature of data reported heretofore precludes definitive conclusions about sequential dependency between the two distal mediators. In the research reported, therefore, the authors manipulated positive affect in the participants (Time 1) and liking of the partner for them (Time 2), and measured trust before attraction. As predicted, liking effects on trust and attraction were stronger when positive affect in the participants was high than when it was low. Importantly, the interaction effect in trust fully mediated the interaction effect in attraction.     

Functional interaction of mGlu5 and NMDA receptors in aversive learning in rats

Metabotropic glutamate receptor 5 (mGlu5) has been implicated in a variety of learning processes and is important for inhibitory avoidance and conditioned taste aversion learning. MGlu5 receptors are physically connected with NMDA receptors and they interact with, and modulate, the function of one another in several brain regions. The present studies used systemic co-administration of an mGlu5 receptor positive allosteric modulator, 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB) and an NMDA receptor antagonist dizocilpine maleate (MK-801) to characterize the interactions of these receptors in two aversive learning tasks. Male Sprague-Dawley rats were trained in a single-trial step-down inhibitory avoidance or conditioned taste aversion task. CDPPB (3 or 10mg/kg, s.c.), delivered by itself prior to the conditioning trial, did not have any effect on performance in either task 48 h after training. However, CDPPB (at 3mg/kg) attenuated the MK-801 (0.2mg/kg, i.p.) induced learning deficit in both tasks. CDPPB also reduced MK-801-induced hyperactivity. These results underlie the importance of mGlu5 and NMDA receptor interactions in modulating memory processing, and are consistent with findings showing the efficacy of positive allosteric modulators of mGlu5 receptors in reversing the negative effects of NMDA receptor antagonists on other behaviors such as stereotypy, sensorimotor gating, or working, spatial and recognition memory.     

The prediction of intelligence in preschool children using alternative models to regression

Statistical prediction of an outcome variable using multiple independent variables is a common practice in the social and behavioral sciences. For example, neuropsychologists are sometimes called upon to provide predictions of preinjury cognitive functioning for individuals who have suffered a traumatic brain injury. Typically, these predictions are made using standard multiple linear regression models with several demographic variables (e.g., gender, ethnicity, education level) as predictors. Prior research has shown conflicting evidence regarding the ability of such models to provide accurate predictions of outcome variables such as full-scale intelligence (FSIQ) test scores. The present study had two goals: (1) to demonstrate the utility of a set of alternative prediction methods that have been applied extensively in the natural sciences and business but have not been frequently explored in the social sciences and (2) to develop models that can be used to predict premorbid cognitive functioning in preschool children. Predictions of Stanford–Binet 5 FSIQ scores for preschool-aged children is used to compare the performance of a multiple regression model with several of these alternative methods. Results demonstrate that classification and regression treesprovided more accurate predictions of FSIQ scores than does the more traditional regression approach. Implications of these results are discussed.     

Imitation in shadowing words

Imitation of shadowed words was evaluated using Goldinger's (1998) AXB paradigm. The first experiment was a replication of Goldinger's experiments with different tokens. Experiment 1's AXB tests showed that shadowed words were judged to be better imitations of target words than were baseline (read) counterparts more often than chance (.50). Order of presentation of baseline and shadowed words in the AXB test also significantly influenced judgments. Degree of prior exposure to token words did not significantly influence judgments of imitation. Experiment 2 employed modified target tokens with extended voice onset times (VOTs). In addition to AXB tests, VOTs of response tokens were compared across baseline and shadowing conditions. The AXB tests revealed shadowed words to be better imitations of target tokens than baseline, without an influence of AXB presentation order. Differences between baseline and shadowing VOTs were greater when VOTs were extended. The implications of spontaneous imitation in nonsocial settings are considered.     

Visual illusions affect both movement planning and on-line control: a multiple cue position on bias and goal-directed action

Over the last decade, there has been an interest in the impact of visual illusions on the control of action. Much of this work has been motivated by Milner and Goodale's two visual system model of visual processing. This model is based on a hypothesized dissociation between cognitive judgments and the visual control of action. It holds that action is immune to the visual context that provides the basis for the illusion-induced bias associated with cognitive judgments. Recently, Glover has challenged this position and has suggested that movement planning, but not movement execution is susceptible to visual illusions. Research from our lab is inconsistent with both models of visual-motor processing. With respect to the planning and control model, kinematic evidence shows that the impact of an illusion on manual aiming increases as the limb approaches the target. For the Ebbinghaus illusion, this involved a decrease in the time after peak velocity to accommodate the 'perceived' size of the target. For the Müller-Lyer illusion, the influence of the figure's tails increased from peak velocity to the end of the movement. Although our findings contradict a strong version of the two visual systems hypothesis, we did find dissociations between perception and action in another experiment. In this Müller-Lyer study, perceptual decisions were influenced by misjudgment of extent, while action was influenced by misjudgment of target position. Overall, our findings are consistent with the idea that it is often necessary to use visual context to make adjustments to ongoing movements.     

Assessment of Rorschach dependency measures in female inpatients diagnosed with borderline personality disorder

The psychometric properties and predictive validity of the Dependency Index (DI; Hilsenroth & Bornstein, 2002) and the Rorschach Oral Dependency Scale (ROD; Masling, Rabie, & Blondheim, 1967) were examined to determine if these implicit measures of dependency predict observable attachment-seeking behavior in 66 female inpatients diagnosed with borderline personality disorder. Results indicate that both scales produce excellent reliability estimates. The DI and ROD yield adequate base rates, and the distributions of scores approximate normal distributions. The DI was predictive of nursing staff observation of positive attachment/treatment compliance (r = .28, p = .02) but not excessive isolation. By contrast, the ROD predicted positive attachment/treatment compliance (r = .38, p = .002) and excessive isolation (r = -.35, p = .004). Texture responses predicted excessive isolation (r = -.25, p = .05). Discriminant validity was supported when neither dependency measure predicted hostile interactions or self-destructive behaviors. Hierarchical regression analyses revealed that the ROD demonstrated incremental validity over the DI and select Comprehensive System (Exner, 1993) variables associated with dependency.     

The fluttering-heart illusion: a new hypothesis

The fluttering-heart illusion is a perceived lagging behind of a colour target on a background of a different colour when the two are oscillated together. It has been proposed that the illusion is caused by a differential in the perceptual latencies of different colours (Helmholtz 1867/1962), a differential in rod-cone latencies (von Kries 1896) and rod-cone interactions (von Grünau 1975, 1976 Vision Research 15 431-436, 437-440; 16 397-401; see list of references there). The purpose of this experiment was to assess the hypothesis that the fluttering-heart illusion is caused by a differential in the perceived velocities of chromatic and achromatic motion. To evaluate this hypothesis, we tested observers possessing normal colour vision and deuteranopes. The perceived delay of a chromatic target relative to an achromatic target was measured as a function of background cone contrast and target colour. For observers with normal colour vision, the perceived delay of the chromatic target is greater in the L-S than the L-M testing conditions. The reverse is observed in deuteranope observers. We suggest that this is caused by the absence of an L-M opponent mechanism contributing to chromatic motion in deuteranopes. Greater background cone contrasts tended to yield smaller perceived delays in both normal and deuteranope observers, indicating that greater chromatic modulation decreases the perceived delay of the colour target. These results support the hypothesis that the fluttering-heart illusion can be explained by a differential in the perceived velocities of chromatic and achromatic motion.