Improving executive functioning in children with fetal alcohol spectrum disorders

An extensive body of literature has documented executive function (EF) impairments in children with fetal alcohol spectrum disorders (FASD); however, few studies have aimed specifically at improving EF. One treatment program that shows promise for children with FASD is the Alert Program for Self-Regulation®, which is a 12-week treatment specifically designed to target self-regulation, a component of EF. The present study sought to examine if Alert would produce improvements in self-regulation that would generalize to other aspects of EF, behavior, and social skills in children with FASD. Twenty-five children aged 8–12 years diagnosed with an FASD were assigned in alternating sequence to either an immediate treatment (TXT) or a delayed treatment control (DTC) group. Both groups received a comprehensive evaluation of EF at baseline and upon completing therapy (TXT), or after a 12- to 14-week interval from baseline (DTC). Parents also completed questionnaires assessing EF and behavior at both time points. For the TXT group only, parent questionnaires were readministered at 6-month follow-up. At the 12-week follow-up, the TXT group displayed significant improvements in inhibitory control and social cognition. Parents of children in the TXT group reported improved behavioral and emotional regulation, as well as reduced externalizing behavior problems. These behavioral improvements along with further improved parent-rated inhibitory control was maintained at the 6-month follow-up. The EF disabilities in children with FASD can be remediated through a targeted treatment approach aimed at facilitating self-regulation skills.     

An Exploratory Study of Discrimination of Composer Style

With an alternate study-test procedure, 254 college students attempted either to free-recall or rearrange in order items of an 11-CVC serial list to a criterion of two consecutive perfect trials. Ss learned the list with or without an isolate which was placed on each of the 11 serial positions. The main findings were as follows: (a) While the reconstruction condition required fewer study trials to criterion than the free-recall condition, the isolation effect occurred equally in both conditions. (b) The isolation effect was a function of the serial position; the effect was greater at the central positions than at the peripherals in free-recall and this trend was essentially reversed in the reconstruction condition. (c) In free-recall, no reliable and systematic spreading effect was obtained for the items immediately preceding and following the isolate; however, a positive spreading effect occurred concurrently with the isolation effect in the reconstruction condition. The isolation effect has been accounted for by a selective rehearsal assumption. Implications regarding the functional cues in serial order learning and the isolation effect in serial learning are suggested.     

The Influence of Acceptance Goals on Relational Perceptions

We examined whether relational perceptions (social involvement, relational value, interaction experience) differ depending on interaction acceptance goals (establish, maintain, or repair). Results indicated that relational perceptions were more positive in the maintain condition compared to the establish condition, which in turn was more positive than the repair condition. The data also supported a moderated mediation model: the indirect effects of social involvement and relational value on the relationship between acceptance goals and participant’s interaction experience were contingent on self-esteem. These findings identify boundary conditions that influence the impact of acceptance goals on how much people experience an interaction positively. The findings provide an integrated framework outlining the potential relationship between acceptance goals, relational perceptions, interaction experience, and self-esteem.     

Does stimulus complexity determine whether working memory storage relies on prefrontal or sensory cortex?

Traditionally, working and short-term memory (WM/STM) have been believed to rely on storage systems located in prefrontal cortex (PFC). However, recent experimental and theoretical efforts have suggested that, in many cases, sensory or other task-relevant cortex is the actual storage substrate for WM/STM. What factors determine whether a given WM/STM task relies on PFC or sensory cortex? In the present article, we outline recent experimental findings and suggest that the dimensionality or complexity of the to-be-remembered property or properties of a stimulus can be a determining factor.     

Can a mind have two time lines? Exploring space-time mapping in Mandarin and English speakers

Spatial representations of time are a ubiquitous feature of human cognition. Nevertheless, interesting sociolinguistic variations exist with respect to where in space people locate temporal constructs. For instance, while in English time metaphorically flows horizontally, in Mandarin an additional vertical dimension is employed. Noting that the bilingual mind can flexibly accommodate multiple representations, the present work explored whether Mandarin–English bilinguals possess two mental time lines. Across two experiments, we demonstrated that Mandarin–English bilinguals do indeed employ both horizontal and vertical representations of time. Importantly, subtle variations to cultural context were seen to shape how these time lines were deployed.     

Improving general intelligence with a nutrient-based pharmacological intervention

Cognitive enhancing substances such as amphetamine and modafinil have become popular in recent years to improve acute cognitive performance particularly in environments in which enhanced cognition or intelligence is required. Nutraceutical nootropics, which are natural substances that have the ability to bring about acute or chronic changes in cognition have also been gaining popularity in a range of settings and applications including the workplace, driving and in the amelioration of age related cognitive decline. Huperzine A, Vinpocetine, Acetyl-l-carnitine, Rhodiola Rosea and Alpha-lipoic Acid are popular nutritional supplements that have shown promising benefits in improving a range of biological (e.g., blood flow, anti-inflammatory, anti-oxidant, and direct neurotransmitter effects) and cognitive processes from in vitro, animal and human clinical research. We report here the first human randomized clinical trial for cognition in which we administer a combination of Huperzine A, Vinpocetine, Acetyl-l-carnitine, R. Rosea and Alpha-lipoic acid (called Ceretrophin) vs placebo. Sixty participants (40 females and 20 males, with a mean age of 45.4 years, SD = 12.6) completed either the odd or even items from the Raven Advanced Progressive Matrices (APM) at baseline and the opposite odd or even items at week 4 after consuming either the combination nootropic or placebo. A significant study visit (time) × treatment condition interaction was found: F (1, 57) = 7.279, p = 0.009, partial η² = .113, with paired samples t-tests revealing a significant improvement in mean APM score from baseline to retest (week 4) (t(34) = ? 4.045, p < .001) for the Ceretrophin? group. Improvements in APM scores could be attributed to the active intervention over the placebo, indicating that the treatment improved general intelligence. Implications for improving our understanding of the biological basis of intelligence and pharmacologically improving human cognition are discussed.     

The relationship between psychopathy and impulsivity: A multi-impulsivity measurement approach

Psychopathy is a serious personality disorder of which impulsivity is a key component. However, impulsivity is a multidimensional construct, with multiple approaches to measurement, and different measures may be differentially implicated in psychopathy. This study investigated the relationship between psychopathy as assessed by the Psychopathic Personality Inventory-Revised (PPI-R; Lilienfeld & Widows, 2005), a personality measure of impulsivity (Barratt Impulsiveness Scale-11), and four behavioural measures of impulsivity (GoStop Impulsivity Paradigm, Two Choice Impulsivity Paradigm, Delay Discounting Task, Iowa Gambling Task). A nonclinical sample (N = 80) was recruited from the local community to advance understanding of psychopathy in non-incarcerated samples. The results indicated that the personality measure of impulsivity was strongly correlated with the PPI-R, while the behavioural measures were either not correlated or only weakly correlated with the PPI-R. The results are discussed in terms of the multifaceted nature of impulsivity and the need for the further development of behavioural measures of impulsivity, given their importance in clinical assessment and intervention.