A Simple, Unified Approach to Bayesian Risk Calculations

A simple, unified approach for calculating Bayesian risks is presented and illustrated with examples. Although new genetic tools have reduced the need for these risk calculations, situations still exist in which consultands need to know these kinds of risks (for example, when no direct test is available for a particular deleterious mutation, or when a consultand wants to know his/her risk before deciding whether to undergo a direct test). The Unified Approach presented here is straightforward and ensures calculating the correct risks. It can be applied to a wide variety of genetic counseling situations, including but not limited to: calculating recurrence or carrier risks for dominant and recessive diseases; incorporating false-positive and false-negative rates on genetic tests into risk calculations; and determining the probability that an isolated case in a family represents a new mutation. The method is based on basic principles of probability and likelihood theory but can be used without sophisticated knowledge of this theory. The method relies on two rules, the Rule of All Configurations and the Rule of Fundamental Probabilities, which are explained and illustrated. The Unified Approach does not represent new or original mathematics but should make it easier for users to calculate risks accurately. A warning is included that complex calculations should always be independently verified by another individual.     

An advocacy intervention program for women with abusive partners: Initial evaluation

Experimentally tested the hypotheses that (1) battered women are in need of numerous community resources upon exit from a domestic violence shelter, (2) working with advocates increases women's effectiveness in obtaining needed resources and social support, and (3) success in obtaining resources and social support increases women's levels of life satisfaction and decreases their risk of further abuse. The initial findings of a short-term intervention project designed to provide postshelter advocacy services to women with abusive partners are presented. One-hundred forty-one battered women were interviewed immediately upon their exit from a domestic violence shelter as well as 10 weeks thereafter. Half the sample was randomly assigned to receive the services of trained advocates who assisted them in accessing needed community resources. Women who worked with advocates reported being more effective in accessing resources and had higher levels of social support and overall quality of life postintervention. Although all women reported some decrease in postshelter abuse, there were no differences between those with and those without advocates, and abuse continued to be a problem for many women.     

Effect of sulpiride on amphetamine-induced activity and stereotyped locomotion

To investigate the hypothesis that sulpiride potentiates stereotyped locomotion at an intermediate dose of amphetamine, rats were assigned to one of four treatment groups (n=7 per group): vehicle + saline; 20 mg/kg sulpiride + saline; vehicle + 3.5mg/kg amphetamine; 20 mg/kg sulpiride + 3.5 mg/kg amphetamine. An automated tracking system was used to record distance moved and sequences of movements between quadrants in a circular open-field. The results showed that amphetamine increased horizontal distance moved, and increased the number and proportion of thigmotaxic trips around the perimeter of the apparatus. Sulpiride reduced amphetamine-induced hyperactivity and the number of perimeter trips, but had no effect on the proportion and maximum run length of perimeter trips. Thus sulpiride reduces the hyperactivity produced by an intermediate dose of amphetamine, but does not appear to affect the stereotyped nature of locomotion under the drug.     

Relating a Social Influence Model to the Role of Acculturation in Substance Use Among Latino Adolescents1

This study examined determinants of substance use derived from the theory of planned behavior as influenced by acculturation. Latino adolescents (n= 448) completed measures of attitudes, subjective norms, perceived behavioral control, intentions toward substance use, and 2 acculturation components. The degree to which Latino adolescents were exposed to as well as use Spanish was unrelated to determinants of future substance use, whereas the degree to which they interact with non-Latino peers exerted a protective effect regarding future substance use. However, both acculturation components influenced the extent social influence determinants predicted future substance use. Intervention strategies may need to consider acculturation in order to effectively direct resources toward those psychosocial determinants of substance use of greatest relevance to Latino populations.     

Some further tests of the constant-ratio rule

Five experiments sought to test the constant-ratio rule (CRR) with single dimensional ensembles composed of 2, 4, or 8 stimulus objects. Each S attempted to identify stimuli which varied in weight or in visual size or brightness. The results demonstrated: (a) The CRR predicts equally well the response proportions of single dimensional visual, kinesthetic, and auditory stimulus ensembles, but less well than those for multidimensional auditory stimuli. (b) Better predictions are obtained with four than with two stimulus objects.(c) The CRR is sensitive to variations in the spacing and range of the stimulus ensembles and to practice on the task. It is concluded that the rule tends to fail whenever stimulus conditions elicit differential amounts of stimulus and response confusion.     

Sleep problems of parents of typically developing children and parents of children with autism

Few researchers have investigated the relation of children's sleep problems to their parents' sleep problems. Children with autism have been reported to evidence greater sleep problems than do typically developing children (C. D. Hoffman, D. P. Sweeney, J. E. Gilliam, & M. C. Lopez-Wagner, 2006; P. G. William, L. L. Sears, & A. Allard, 2004). In the present study, parents (N = 106) of children independently diagnosed with autism (4-16 years of age; M= 8.20 years, SD = 2.69 years) reported greater sleep problems for themselves than did parents (N = 168) of typically developing children (4-15 years of age; M = 8.62 years, SD = 3.28 years). Children's sleep problems were related to parents' sleep problems for both groups; in the autism group, children's level of symptomatology was not related to their parents' sleep. The authors suggest areas for further research on the sleep problems of children and their parents, the potential interaction of these problems with children's symptomatic behavior, and the relations of these factors to child, parent, and family functioning.     

Activating Basic Category Exemplars in Sentence Contexts: A Dynamical Account

This paper examines the influence of context on the processing of category names embedded in sentences. The investigation focuses on the nature of information available immediately after such a word is heard as well as on the dynamics of adaptation to context. An on-line method (Cross Modal Lexical Priming) was used to trace how this process unfolds in time. We found that the information available immediately after a category word is presented is not altered by the sentence context in which the word is immersed. Rather, the structure of availability of particular exemplars of the category resembles the typicality structure of a conceptual representation. The adaptation to context occurs later (between 300 and 450 ms after the category word) and takes the form of a rapid reorganization of the structure rather than a gradual activation of a contextually relevant exemplar. We claim that such data is best accounted for in a dynamical framework, where a coherent global structure emerges through locally guided self-organization.     

Preferences versus strategies as explanations for culture-specific behavior

In this article, we present a new framework for interpreting cultural differences in behavior -- what we call the institutional approach. In this framework, individuals' behaviors are conceptualized as strategies adapted to various incentive structures. Cultural differences in behavior are thus viewed as differences in the default adaptive strategies that individuals come to rely on in unclear situations. Through two studies, we demonstrate that the East Asian "preference" for conformity is actually a default strategy to avoid accrual of negative reputation. When the possibility for negative evaluations in a given situation was clearly defined, cultural differences in the tendency for uniqueness disappeared. This approach carries important implications to psychologists who interpret cultural differences in behavior in terms of preferences, and can serve as a common framework branching out toward other disciplines in the social sciences.