How clinical trials really work rethinking research ethics

Despite prevalent concerns about the ethical conduct of clinical trials, little is known about the day-to-day work of trials and the ethical challenges arising in them. This paper reports on a study designed to fill this gap and demonstrates a need to refine the oversight system for trials to reflect an understanding of this day-to-day work. It also illuminates ethical challenges that cannot be addressed by the oversight system and so necessitate a rethinking of the ethics of clinical trials.     

Literary arts and the development of the life story

Throughout adolescence, children begin to develop their life story: a coherent account of their experiences and selfhood. Although the nature of this development is still being uncovered, one promising direction for research is the examination of factors that could encourage life story development. Here the authors explore the idea that exposure to the literary arts (i.e., poetry and fictional literature) might promote the formation of a coherent autobiographical narrative. Taking a critical look at both theoretical proposals along with the current empirical research, they provide a brief survey of this intriguing hypothesis.     

Media exposure, internalization of the thin ideal, and body dissatisfaction: comparing Asian American and European American college females

Internalization of the thin ideal mediates the media exposure-body dissatisfaction relation in young adult European American females. There is little related research on Asian Americans. We used structural equations modeling to test: (1) whether media exposure was associated with body dissatisfaction in Asian American young adult females, (2) internalization of the thin ideal mediated any such association, and (3) whether the mediational model provided equivalent fit for European American and Asian American samples. Participants were 287 college females (154 Asian Americans, 133 European Americans). Internalization of the thin ideal explained the media exposure-body dissatisfaction association equally well for both groups. Results suggest that Asian Americans may be employing unhealthy weight control behaviors, and may be prone to developing eating disorders, at rates similar to European American young adult females. Clinicians need to screen carefully for body dissatisfaction, unhealthy weight control behaviors, and eating disorders in Asian American females.     

Axiomatic Extensions of IMT3 Logic

In this paper we characterize, classify and axiomatize all axiomatic extensions of the IMT3 logic. This logic is the axiomatic extension of the involutive monoidal t-norm logic given by ¬φ³ ∨ φ. For our purpose we study the lattice of all subvarieties of the class IMT3, which is the variety of IMTL-algebras given by the equation ¬(x³) ∨ x ≈ ?, and it is the algebraic counterpart of IMT3 logic. Since every subvariety of IMT3 is generated by their totally ordered members, we study the structure of all IMT3-chains in order to determine the lattice of all subvarieties of IMT3. Given a family of IMT3-chains the number of elements of the largest odd finite subalgebra in the family and the number of elements of the largest even finite subalgebra in the family turns out to be a complete classifier of the variety generated. We obtain a canonical set of generators and a finite equational axiomatization for each subvariety and, for each corresponding logic, a finite set of characteristic matrices and a finite set of axioms.     

Discriminating among diagnostic categories using the Dissociative Disorders Interview Schedule

The Dissociative Disorders Interview Schedule was administered to 1,308 subjects in eight diagnostic categories, including 296 with dissociative identity disorder. The study tested three hypotheses: (1) the Mahalanobis distance between dissociative identity disorder and each of seven other diagnostic categories would be large, (2) the closest diagnostic category to dissociative identity disorder would be dissociative disorder not otherwise specified, and (3) nondissociative diagnostic categories would be closer to each other than any one to dissociative identity disorder. All three hypotheses were confirmed by these data. The findings support the conclusion that dissociative identity disorder is a discrete category or taxon.     

Empirical research on research ethics

Ethics is normative; ethics indicates, in broad terms, what researchers should do. For example, researchers should respect human participants. Empirical study tells us what actually happens. Empirical research is often needed to fine-tune the best ways to achieve normative objectives, for example, to discover how best to achieve the dual aims of gaining important knowledge and respecting participants. Ethical decision making by scientists and institutional review boards should not be based on hunches and anecdotes (e.g., about such matters as what information potential research participants would want to know and what they understand, or what they consider to be acceptable risks). These questions should be answered through empirical research. Some of the preceding articles in this special issue illustrate uses of empirical research on research ethics. This article places empirical research on research ethics into broader perspective and challenges investigators to use the tools of their disciplines to proactively solve ethical problems for which there currently exist no empirically proven solutions.     

Men's and Women's Perceptions of the Gender Typing of Management Subroles

The purpose of this study was to investigate the extent to which subroles inherent in managerial positions are gender-typed and whether men or women engage in relatively more gender typing of managerial roles. We obtained perceptions of 19 management subroles from 263 business students in the United States Results confirmed predictions that some subroles are viewed as more feminine in nature whereas other subroles are perceived as more masculine. Male respondents saw most subroles as more masculine in nature than did female respondents. Results are discussed in terms of implications for researchers studying management, as well as for managers in the workplace.     

Spatial interference and response control in sequence learning: the role of explicit knowledge

In several sequence learning studies it has been suggested that response control shifts from the stimuli to some internal representation (i.e., motor program) through the learning process. The main questions addressed in this paper are whether this control shift is related to explicit knowledge and whether the formation of these internal representations depends on the stimulus attributes. In one experiment we compared the learning of a response sequence triggered by either spatial location or location symbol (left-right) by using a serial response task (SRT). Symbols were presented at either a centered or random location. The results showed that in the symbolic conditions the shift of response control correlated with the emergence of explicit knowledge. Only participants with complete explicit knowledge seemed to learn the sequence structure beyond probabilistic information (response time "RT" did not depend on the frequency of the response). Moreover, these participants were able to overcome, when needed, spatial interference (RT was the same for both spatially corresponding and non-corresponding trials). However, when spatial location was relevant, RT was always faster, especially for more frequent responses. These results suggest that the relevant stimulus dimension (location or symbol) seems to engage different sequence learning mechanisms.     

Moderators of the Relation Between Popularity and Depressive Symptoms in Children: Processing Strength and Friendship Value

Children with low (n = 25) and high (n = 38) peer-rated popularity completed an emotional Stroop task, using negative social words, a self-report measure of friendship value relative to other domains of competence, and the Child Depression Inventory (CDI). Six months later, they completed the CDI again. In regression analyses, after controlling for prior CDI scores, social status interacted significantly with both Stroop and value measures (separate regressions). For unpopular children, both greater friendship valuing and greater negative social word Stroop interference predicted increases in depressive symptoms. In contrast, neither predictor was significant for popular children. In a third regression that included friendship value and Stroop interference as joint predictors of depression change, their effects remained significant and independent. We discuss these findings' implications for 3 models of depression; Champion and Power's social-cognitive theory of depression (L. A. Champion and M. J. Power, 1995), Pyszczynski and Greenberg's self-regulatory perseveration theory of depression (T. Pyszczynski & J. Greenberg, 1992), and Harter's model of global self-worth (S. Harter, 1985).     

Teacher Burnout and Lack of Reciprocity1

Results are presented of a study on burnout among 249 Dutch elementary and secondary school teachers. The current study considers burnout in terms of the exchange of investments and outcomes at interpersonal (teacher-student) and organizational (teacher-school) levels. In addition, demographic (age and gender) and work-related factors (school type, teaching experience, number of hours employed) are included. Findings show that when teachers invest more than they get back from their school, they report higher levels of emotional exhaustion. As expected, at the interpersonal level, low outcomes from students are related to higher burnout levels; whereas at the organizational level, low investments are related to higher burnout levels. These findings are discussed in terms of the extent to which psychological contact is more intimate or impersonal in both types of relationships.