Effects of two-year treatment with the cholinesterase inhibitor rivastigmine on behavioural symptoms in Alzheimer's disease

Alzheimer's disease (AD) is accompanied by prominent behavioural disturbances. They cause significant distress for both caregivers and patients and can play a major role in the decision to institutionalise AD patients. Recent evidence suggests that cholinergic deficiencies not only contribute to the memory and cognitive abnormalities of AD but are also responsible for some behavioural abnormalities seen over the course of the disease. In this study we assessed the ability of rivastigmine, a pseudo-irreversible cholinesterase inhibitor, to improve behavioural and psychopathologic symptoms in AD. The analysis included 34 patients present in the Germanarm of the international study B303 who received and completed long-term treatment with rivastigmine in the open-label study B305. Assessments of behaviour and psychopathological symptoms were performed using the behavioural component of the Clinicians Interview Based Impression of Change Plus (CIBIC-Plus). Results show that long-term treatment with rivastigmine can slow the progression of behavioural and psychopathological symptoms of AD. Behavioural symptoms showing stabilisation included aggressiveness, activity disturbances, hallucinations and paranoid features. Results also suggest that patients treated earlier with rivastigmine may attain a greater benefit compared with patients whose treatment is delayed 6 months. Further studies examining the effects of rivastigmine on behavioural disturbances in AD are therefore warranted.     

Accentuation effects and illusory change in exemplar-based category learning

Examined the hypothesis that information enhancing category differences receives greater weight in estimates of category means than information that reduces such differences. In the first experiment, subjects estimated the cumulative means of test scores of two groups of students. The experimental manipulation involved a gradual shift of the true mean of one group either towards or away from the true mean of the other group. As predicted, changes of estimates were larger when the two means became more dissimilar than when they became more similar. The second experiment involved otherwise identical procedures, but the variance in one category was increased while the mean remained stable. Subjects perceived an illusory change of the mean away from the comparison category. It is suggested that accentuation effects of this kind may limit the reduction of social stereotypes.     

Inhibited power motivation and persuasive communication: a lens model analysis

The authors tested the hypothesis that after motive arousal, individuals with an inhibited power motive (IPM) would excel at a persuasive task and explored the behavioral strategies IPM individuals use to that purpose. Sixty-eight participants presented their point of view on a controversial subject to another person. Power motivation and inhibition were both assessed by a picture-story test. Prior to their presentation, half of the participants imaginatively explored the ensuing task. The other half was assigned to a no-imagery control condition. Lens model analysis of videotaped presentations revealed that IPM participants in the imagery condition were judged to be the most persuasive of all participants. This interactive effect of power motivation, inhibition, and imagery condition was accounted for by three behavioral cues: verbal fluency, gesturing, and eyebrow lifts. No comparable effects emerged among no-imagery participants.     

Local contextual cuing in visual search

Previous research has indicated that covariations between the global layout of search displays and target locations result in contextual cuing: the global context guides attention to probable target locations. The present experiments extend these findings by showing that local redundancies also facilitate visual search. Participants searched for randomly located targets in invariant homogenous displays, i.e., the global context provided information neither about the location nor about the identity of the target. The only redundancy referred to spatial relations between the targets and certain distractors: Two of the distractors were frequently presented next to the targets. In four of five experiments, targets with frequent flankers were detected faster than targets with rare flankers. The data suggest that this local contextual cuing does not depend on awareness of the redundant local topography but needs the redundantly related stimuli to be attended to.     

Visual analogue scales for mode-independent measurement in self-administered questionnaires

Previous research has shown evidence for mode differences between computer-assisted self-administered interviews (CASI) and paper-and-pencil interviews, especially in the case of sensitive questions. Some of these differences are explained by higher degrees of self-disclosure for CASI than for paper-and-pencil interviews, due to the more private situation with CASIs. This analysis examines the existence of different degrees of self-disclosure for CASI versus paper-and-pencil questionnaires and whether these differences can be reduced by the use of a specific response format. Judgments of items on a self-control scale with discrete 5-point (Likert-type) scales are compared with judgments on continuous visual analogue scales (VAS). Because a categorization effect for Likert-type items is assumed when pressure for social desirability is present, it is hypothesized that VAS compared to Likert-type response formats are less sensitive to mode differences.     

Eye vergence is susceptible to the hollow-face illusion

When an observer looks at a hollow mask of a face, a normal convex face is often perceived [the hollow-face illusion--Gregory 1973, in Illusion in Nature and Art (London: Duckworth) pp 49-96]. We show that in exploring an illusory face, the eyes converge at the illusory and not at the real distances of fixated targets like the tip of the nose. The 'vergence error' appears even though the resulting disparities of the two retinal images of the target provide feedback that would allow an immediate correction. It is presumably the success of recognising a familiar object (a face) which overrides the correction of convergence. This suggests that the brain strives for a congruency of eye vergence and distance perception.     

The Chinese Version of the Revised Creativity Domain Questionnaire (CDQ‐R): First Evidence for its Factorial Validity and Systematic Association with the Big Five

The present study examines the factor structure of a Chinese version of the Revised Creativity Domain Questionnaire (CDQ‐R; Kaufman, Waterstreet, Ailaouni, Whitcomb, Roe, & Riggs, 2009) as well as its relation to Big Five personality traits within a Chinese sample (N = 787). Analyses indicate the appropriateness of the Chinese version of the CDQ‐R in terms of internal consistency, factorial validity as well as convergent and divergent validity concerning the Big Five personality factors. Revealing some culture‐specific variation, confirmatory factor analysis indicated a slight superiority of a five‐factor model for this Chinese sample over the existing four‐factor model established with American samples. This higher level of differentiation in terms of one factor of the creativity domain could be explained on the basis of the specific characteristics of the Chinese culture.