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Timing is essential for rapid effects of corticosterone on synaptic potentiation in the mouse hippocampus
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Stress facilitates memory formation, but only when the stressor is closely linked to the learning context. These effects are, at least in part, mediated by corticosteroid hormones. Here we demonstrate that corticosterone rapidly facilitates synaptic potentiation in the mouse hippocampal CA1 area when high levels of the hormone and high-frequency stimulation coincide in time, but not when corticosterone is given either before or after repetitive stimulation. This effect could not be blocked by antagonists of the mineralocorticoid receptor and glucocorticoid receptor (spironolactone and RU 38486, respectively). These data provide a biological substrate for the important behavioral observation that stress and corticosteroid hormones can facilitate learning and memory processes. 相似文献
74.
What information is used for sorting pictures of complex stimuli into categories? We applied a reverse correlation method to reveal the visual features mediating categorization in humans and baboons. Two baboons and 6 humans were trained to sort, by species, pictures of human and baboon faces on which random visual noise was superimposed. On ambiguous probe trials, a human-baboon morph was presented, eliciting "human" responses on some trials and "baboon" responses on others. The difference between the noise patterns that induced the two responses made explicit the information mediating the classification. Unlike the humans, the baboons based their categorization on information that closely matched that used by a theoretical observer responding solely on the basis of the pixel similarities between the probe and training images. We show that the classification-image technique and principal components analysis provide a method to make explicit the differences in the information mediating categorization in humans and animals. 相似文献
75.
76.
Dialectical Behavior Therapy for Binge Eating Disorder (DBT-BED) aims to reduce binge eating by improving adaptive emotion-regulation skills. Preliminary findings have been promising but have only compared DBT-BED to a wait-list. To control for the hypothesized specific effects of DBT-BED, the present study compared DBT-BED to an active comparison group therapy (ACGT). Men and women (n = 101) meeting DSM-IV BED research criteria were randomly assigned to 20 group sessions of DBT-BED (n = 50) or ACGT (n = 51). DBT-BED had a significantly lower dropout rate (4%) than ACGT (33.3%). Linear Mixed Models revealed that posttreatment binge abstinence and reductions in binge frequency were achieved more quickly for DBT-BED than for ACGT (posttreatment abstinence rate = 64% for DBT-BED vs. 36% for ACGT) though differences did not persist over the 3-, 6-, and 12-month follow-up assessments (e.g., 12-month follow-up abstinence rate = 64% for DBT-BED vs. 56% for ACGT). Secondary outcome measures revealed no sustained impact on emotion regulation. Although both DBT-BED and ACGT reduced binge eating, DBT-BED showed significantly fewer dropouts and greater initial efficacy (e.g., at posttreatment) than ACGT. The lack of differential findings over follow-up suggests that the hypothesized specific effects of DBT-BED do not show long-term impact beyond those attributable to nonspecific common therapeutic factors. 相似文献
77.
Jordan P. LaBouff Wade C. Rowatt Megan K. Johnson Michelle Thedford Jo‐Ann Tsang 《Journal for the scientific study of religion》2010,49(3):439-455
An implicit measure of religiousness‐spirituality (RS) was constructed and used in two studies. In Study 1, undergraduates completed a Religiousness‐Spirituality Implicit Association Test (RS‐IAT) and several self‐report measures of RS and related constructs (e.g., religious fundamentalism, authoritarianism). Informants rated the participants’ RS. The RS‐IAT was internally consistent. Implicit RS correlated positively with self‐reported RS, spiritual transcendence, spiritual experiences, religious fundamentalism, and intrinsic religiousness. Informant ratings correlated positively with participants’ self‐reported religiousness but not implicit RS. In Study 2, implicit RS accounted for unique variability in self‐reported attitudes toward gay men and lesbian women when controlling for self‐reported religiousness and right‐wing authoritarianism. These findings demonstrate that an implicit measure of trait RS explains some variability in attitudes that self‐report measures do not. An implicit measure of RS could advance the scientific study of religion beyond what is known from self‐report measures. 相似文献
78.
Few studies have explored the effects of fixed‐time (FT) reinforcement on escape‐maintained behavior of students in a classroom setting. We measured the effects of an FT schedule on the disruptive and appropriate academic behaviors of 2 junior high students in a public school setting. Results demonstrated that FT escape from tasks resulted in a substantial decrease in disruptive behavior and an increase in time engaged in tasks for both participants. 相似文献
79.
Swami V Furnham A Chamorro-Premuzic T Akbar K Gordon N Harris T Finch J Tovée MJ 《The Journal of social psychology》2010,150(6):628-647
This study examined the influence of personality information on perceptions of the physical attractiveness of a range of female body sizes. A sample of 2,157 male university students were randomly assigned to one of 10 groups in which they received personality information about women they were rating, or a control group in which they received no personality information. Controlling for participants' age and body mass index, results showed no significant between-group differences in the body size that participants found most attractive. However, participants provided with positive personality information perceived a wider range of body sizes as physically attractive compared with the control group, whereas participants provided with negative personality information perceived a narrower range of body sizes as attractive. Correlations showed that participants' own Extraversion was associated with their body size ratings. These results suggest that non-physical cues have an influence on the perception of physical beauty. 相似文献
80.
Correlation Weights in Multiple Regression 总被引:1,自引:0,他引:1
A general theory on the use of correlation weights in linear prediction has yet to be proposed. In this paper we take initial
steps in developing such a theory by describing the conditions under which correlation weights perform well in population
regression models. Using OLS weights as a comparison, we define cases in which the two weighting systems yield maximally correlated
composites and when they yield minimally similar weights. We then derive the least squares weights (for any set of predictors)
that yield the largest drop in R
2 (the coefficient of determination) when switching to correlation weights. Our findings suggest that two characteristics of
a model/data combination are especially important in determining the effectiveness of correlation weights: (1) the condition
number of the predictor correlation matrix, R
xx
, and (2) the orientation of the correlation weights to the latent vectors of R
xx
. 相似文献