深切怀念任公继愈先生

任公继愈先生永远离开了我们。 作为学生和后辈学者，想到先生的学术造诣、做事为人，总是抑制不住内心的激动和悲痛。     

Perforant path activation modulates the induction of long-term potentiation of the schaffer collateral--hippocampal CA1 response: theoretical and experimental analyses

In one computational model of hippocampal function, the entorhinal cortical input to CA1 is hypothesized to play a key role in the ability of CA1 to decode CA3 recodings. Here, we develop a modification of this CA1 decoder hypothesis that is applicable to several computational theories of hippocampal function, and then we electrophysiologically investigate one assumption of this new hypothesis. First, using biologically realistic estimates, we calculate that CA3-induced CA1 excitation is too high and that inhibition plausibly plays a role in this CA1 decoder model. Thus motivated, we turn to a physiological demonstration to substantiate the plausibility of the proposed mechanism. Using the rat hippocampal slice, we examine an interlaminar interaction between the distal perforant path input to hippocampal CA1 stratum moleculare and the more proximal Schaffer collateral input to stratum radiatum. Perforant path activation provides sufficient inhibition to block homosynaptic long-term potentiation elicited by a suitably strong stratum radiatum input. For this interlaminar interaction to be most effective, perforant path activation must both precede and follow Schaffer collateral activation. Perforant path-evoked inhibition in CA1 can thus serve as a viable mechanism in the learned decoder theory of hippocampal CA1.     

Coping with Abusive Supervision: the Neutralizing Effects of Perceived Organizational Support and Political Skill on Employees’ Burnout

While research into the antecedents of burnout has steadily grown, the relationship between abusive supervision and burnout remains largely unknown. In addition, we know little about the contingencies under which abusive supervision may be related to employees’ burnout. This study aims to examine the contingency side of the abusive supervision-burnout relationship by addressing the exploratory question of whether perceived organizational support and individual differences in political skill play moderating roles in the abusive supervision-burnout relationship. The present article developed a model and tested it with data from a sample of 248 supervisor–subordinate dyads. We hypothesized and found that (1) Abusive supervision was positively associated with burnout; (2) the positive relationship between abusive supervision and burnout was moderated by the employees’ perceived organizational support in such a way that the relationship was weaker for employees who perceive higher rather than lower organizational support; (3) the positive relationship between abusive supervision and burnout was moderated by the employees’ political skill in such a way that the relationship was weaker for people with high, rather than lower level of political skill.     

Nodule Detection with Eye Movements

Radiologists often miss nodules that may represent lung cancer on chest radiographs. We investigated whether eye movements collected during the search for lung nodules by large samples of laypeople may provide information that could assist radiologists in their detection. For that purpose, we developed a partially invisible Markov model with partially unobserved states and analyzed eye tracking data of over 100 laypeople who reviewed 14 chest X‐ray images, of which seven contained a potentially cancerous nodule. We used the luminance value of the pixels in the X‐ray images as prior information on the possible location of a nodule and identified six regions of interest on each image that may contain a nodule. Our study demonstrated that the eye movements recorded from laypersons contained information that may assist radiologists in the detection of nodules in chest X‐rays, which has important implications for crowdsourcing of search for pulmonary nodules, which are discussed. Copyright © 2016 John Wiley & Sons, Ltd.     

Differences in the micromechanical properties of dendrites and interdendritic regions in superalloys

Statistical analysis of white-light interferometry (WLI) experiments performed on Ni-based single-crystal superalloys (SX) have revealed a different height distribution between the dendritic cores (DCs) and the interdendritic regions (IRs) of the polished samples. The micromechanical property difference is largely ascribed to the uneven distribution of the alloying elements. In this context, possible reasons for this difference are discussed by comparing with different experiment results obtained by previous researchers, and a proposal forecasting the hardness ratio of IRs/DCs is put forward.     

Internet Addiction and Well-Being: Daoist and Stoic Reflections

This article explores the phenomenon of Internet addiction and its possible amelioration, from both Eastern and Western philosophical perspectives. Internet addiction is caused by the excessive use of the Internet and its resulting dependence, having negative effects on human well-being. The ideas of a key ancient Chinese Daoist thinker Zhuangzi 莊子 and his Western contemporaries, the Stoics, as viewed through the world, the things and beings in it, and their relationships, offer insights which may be used to alleviate these effects. The application of and comparison between the two ancient philosophies in addressing the issue of Internet addiction can give us inspiration to confront the challenges of technological enslavement in general and Internet addiction in particular. This is no doubt a help in our pursuit of well-being.     

在综合基础上创新——鼠伤寒菌pla基因及其功能研究的思考

鼠伤寒菌pla基因及功能的研究从课题确立到取得结果整个过程,充分展现了综合研究方法在现代科学研究中的重要作用;在综合基础上的创新是科学研究成功的中心环节。