Verbal–spatial IQ discrepancies impact brain activation associated with the resolution of cognitive conflict in children and adolescents

Verbal–spatial discrepancies are common in healthy individuals and in those with neurodevelopmental disorders associated with cognitive control deficits including: Autism Spectrum Disorder, Non‐Verbal Learning Disability, Fragile X, 22q11 deletion, and Turner Syndrome. Previous data from healthy individuals suggest that the magnitude of the difference between verbal IQ (VIQ) and performance IQ (PIQ) scores (the VIQ>PIQ discrepancy) is associated with reduced thickness in frontal and parietal cortices (inferior frontal, anterior cingulate, inferior parietal lobule, and supramarginal gyrus) that support cognitive control. Unknown is whether the VIQ>PIQ discrepancy is associated with functional deficits in these areas in healthy or ill children and adolescents. We assessed the effects of the VIQ>PIQ discrepancy on fMRI BOLD response during the resolution of cognitive conflict in 55 healthy children and adolescents during performance of a Simon Spatial Incompatibility task. As the magnitude of the VIQ>PIQ discrepancy increased, activation of fronto‐striatal, limbic, and temporal regions decreased during conflict resolution (p < .05, corrected). In exploratory analyses, the VIQ>PIQ discrepancy was associated with reduced functional connectivity from right inferior frontal gyrus to right thalamus and increased functional connectivity to right supramarginal gyrus (ps < .03, uncorrected). The VIQ>PIQ discrepancy may be an important aspect of an individual's cognitive profile and likely contributes to, or is associated with, deficient cognitive control processes characteristic of many childhood disorders.     

Perceiving high social mindfulness during interpersonal interaction promotes cooperative behaviours

Social mindfulness refers to individual's respect and protection of others’ options in interpersonal interaction. The object‐choosing task is a traditional paradigm to assess social mindfulness. Individuals with high social mindfulness would choose the nonunique object so that others would have more options; on the contrary, individuals with low social mindfulness would choose the unique object, which limits others’ choices. No prior study has examined whether perceiving people with different levels of social mindfulness affects one's cooperation. Based on this background, two experiments were conducted to address this question. In both experiments, a confederate participant's (Player A's) social mindfulness was manipulated by setting the frequency that Player A chose the unique and the nonunique objects. Then, participants were asked to interact with Player A in the public goods game (Experiment 1) or in the centipede game (Experiment 2). Convergent results showed that compared to those interacting with a socially unmindful person, participants interacting with a person perceived as socially mindful contributed more resources in the public goods game and chose to pass on more rounds in the centipede game. These findings suggest that perception of others’ high social mindfulness enhances one's own cooperative behaviour.     

论王阳明龙场所悟之“道”

明正德三年(1508)王阳明在贵州龙场悟道,这是他学术思想上的分水岭。阳明龙场所悟之道,从直接的内容看,不外是对格物致知之说的重新理解,而其深层的内涵则颇为复杂,主要包括了心外无理、心外无物和致知格物三个内容。     

脊柱侧弯手术治疗进展

随着医学技术的发展,脊柱侧弯的治疗方法也在不断的进步。针对其治疗方法的改变,提出以下思考和分析：（1）脊柱侧弯的治疗方法遵循着螺旋式上升,曲折式前进的发展过程;（2）运用适度原则和最优化原则,为患者制定个体化治疗方案;（3）运用运动发展的眼光即动态性原则来观察和解决脊柱侧弯手术治疗中存在的问题。     

先秦国家安全思想及其当代借鉴价值

在中国历史上,关于国家安全问题的战略性思考起源于先秦时期,许多重要的指导思想和原则,如以民为本、和而不同、慎战、亲仁善邻等思想已在那时得到了明晰。这些宝贵的思想具有久远而深厚的文化基础。他们不仅为历朝历代安内攘外,维系中国作为世界上唯一不曾中断几千年文明进程的国家发挥了重要的历史作用。而且对于我们今天研究安全问题、制定国家安全战略提供了可资借鉴的价值。     

社会判断偏差的分化研究：人物因素的影响

实验采用投射的方法,利用图片和问题材料,考察了128名本科生对物、事、人的社会判断偏差的分化现象。实验结果表明：1）社会判断内在的宽大效应存在局限性,它是有条件限制的,受到所介入的人物因素的影响而出现分化现象;2）对物与事的评价中,突出了对性别判断标准的差异;3）在社会人的对比中,容貌、性别、背景在对同一事件的判断中发挥着重要作用,使社会判断出现偏差分化。     

上清派炼养术的藏象学说内涵探讨

上清派是道教的一个重要流派,形成于魏晋时期,创始人相传为西晋女道士魏华存。该派以《上清经》、《黄庭经》、《真诰》等道书为主要经典,以存思、守神、行气、服食为主要修炼手段,对道学及中医学都有着深远的影响。魏晋时     

Acute starvation in C57BL/6J mice increases myocardial UCP2 and UCP3 protein expression levels and decreases mitochondrial bio-energetic function

Associations between uncoupling protein (UCP) expression and functional changes in myocardial mitochondrial bio-energetics have not been well studied during periods of starvation stress. Our aim was to study the effects of acute starvation, for 24 or 48 h, on combined cardiac mitochondrial function and UCP expression in mice. Isolated heart mitochondria from female mice starved for 48 h compared to that from mice fed revealed a significantly (p < 0.05) decreased adenosine diphosphate-to-oxygen ratio, a significantly increased proton leak and an increased GTP inhibition on palmitic acid-induced state 4 oxygen consumption (p < 0.05). These bio-energetic functional changes were associated with increases in mitochondrial UCP2 and UCP3 protein expression. In conclusion, our findings suggest that increased UCP2 and UCP3 levels may contribute to decreased myocardial mitochondrial bio-energetic function due to starvation.     

论犹太教对外邦人改宗的矛盾态度

犹太教是一个民族性的宗教。对改宗犹太教的外邦人,拉比们一方面给予他们积极的评价,另一方面又对他们表现出怀疑排斥的消极态度。从根本上说,这种矛盾态度是由犹太教对自身的不同理解造成的。一方面,犹太人将自身看成由律法塑造的宗教共同体;另一方面,犹太教又始终将自身理解为一个民族,甚至其改宗程序,也是为了在象征意义上建立改宗者与犹太人的血缘关系。犹太教对其民族性的坚持是她无法向外邦人敞开怀抱的主要原因。