伏隔核和中脑腹侧被盖区内食欲素在吗啡奖赏中的作用

实验采用条件性位置偏爱（CPP）模型考察中脑腹侧被盖区（VTA）和伏隔核壳区（NAcSh）内食欲素（orexin）在吗啡奖赏中的作用。Wistar大鼠分为盐水训练组和吗啡训练组。3轮吗啡（或盐水）匹配训练前,双侧VTA或NAcSh内给予OXR1拮抗剂SB334867（VTA: 0, 1, 5μg;NAcSh: 0, 1, 3μg）;或2轮吗啡（或盐水）匹配训练前NAcSh内给予orexin A（0, 2, 4, 6μg）,观察其对吗啡CPP建立的影响。结果表明,VTA内给予SB334867抑制吗啡CPP建立,并存在剂量效应关系;NAcSh内给予SB334867或orexin A均未影响吗啡CPP建立,而orexin A可增加吗啡处理大鼠的运动性。以上结果表明,VTA和NAcSh内的orexin在吗啡奖赏中扮演的角色不同,可能调控成瘾行为的不同成分     

大学生人格评定的和谐追求——200个人格词汇喜好度中美对比研究

本研究选取Anderson1968年研究中的200个核心人格特质词汇,请165名在校大学生对词汇进行喜好度评定.对比Anderson(1968)的研究结果,发现:1)中西方被试均将真诚评定为最受欢迎的个性品质;2)中国被试作答较少出现极端值;3)中国被试评出的前10位积极品质均与人际和谐有关;而西方被试评出的前10位积极品质主要涉及诚信和个人能力两方面;4)中西方被试评出的前10位消极词汇均为他相关词汇,并和积极词汇相对应.     

道德与自然:"形上之道"与"形而上学"的本质区别

Both thinkings on Dao in Chinese philosophy and metaphysics in Western philosophy investigate things on a spiritual level that transcends experience, but there are incommensurable differences between them. The objective of “metaphysics” is ontological knowledge about nature from the perspective of epistemological “truth-pursuing”. Western metaphysics is thus a “metaphysics of nature”. Dao in Chinese philosophy, on the other hand, more often manifests itself in “good-pursuing” by means of the internal, experiential pursuit of moral stature and spiritual security. Philosophy of Dao is thus a “metaphysics of ethics”. The cause of this difference can be traced back to the differences between the rational tradition of the West, characterized by the dualism of the subject and the object, and the moral tradition of China, characterized by the integration of man and nature. __________ Translated by Zhang Lin from Lunlixue yanjiu 伦理学研究 (Studies in Ethics), 2007, (4): 62–65     

抑郁症患者的自传体记忆特征及其应用自传体记忆测验的元分析

研究目的在于探讨抑郁症患者自传体记忆的特征以及自传体记忆测验(the autobiographical memory test, AMT)在该领域的应用情况。通过文献检索, 搜集了18篇应用AMT作为测评工具的抑郁症自传体记忆研究, 抑郁症患者566人, 正常对照组457人。元分析研究发现, 和正常对照组比较, 抑郁症组的具体性记忆减少, 概括化记忆增多, 反应迟缓。目前对这种现象的解释主要有功能性回避模型、认知执行受损模型和沉思模型; 年龄、抑郁情绪以及AMT测试程序对测试结果有明显影响; 发表偏倚和敏感性分析显示存在发表偏倚, 但稳定性较好。AMT在抑郁症研究存在灵敏度不足等局限, 作者从AMT程序、研究设计等方面提出了改善建议。     

趋化因子10与临床疾病关系的研究进展

趋化因子10（CXCL10）是由干扰素诱导产生,过去又把它称为干扰素-γ诱导蛋白10（IFN—γIndueible protein 10）。其具有强大的招募中性粒细胞、促进多种细胞因子分泌及抑制部分肿瘤生长等多种生物学作用。在慢性炎症、过敏性炎症、自身免疫性疾病、移植物排斥反应和肿瘤等多种疾病的病理过程中起重要作用。     

重庆市直辖以来卫生资源配置公平性研究

采用基尼系数方法从人口和地理分布两个方面定量分析重庆市卫生资源配置的公平性。重庆市主要卫生资源中,护士的基尼系数最高;重庆市的三个经济区域中,都市发达经济圈的基尼系数最高;资源按地理配置的公平性要差于按人口配置。重庆市护理人员严重不足且分布不公平,资源地理配置的公平性有待改善。     

中国传统诚信观的演变及其特征

中国传统诚信观在春秋以前萌芽,形成于春秋至战国时期,秦汉时期被规范化,宋明时期具有强烈的哲理化倾向,到明清时期走向了实用化的道路.中国传统诚信观具有强烈的自律倾向、浓郁的情感色彩和单向的道德义务的基本特点.     

“就是给病人做了点东西”——访著名骨科专家卢世璧院士

翻开卢世璧院士的简历,一连串的首创性成果格外引人注目:在国内首先开展了人工关节的系列研究及临床应用;率先开展火器性周围神经伤的自体神经移植;首创形状记忆合金棒治疗脊柱侧弯;第一个研制成功国产关节连续被动活动器(CPM机);首先采用微波热疗治疗骨肿瘤;首先利用引导性组织再生概念进行长骨再生实验研究;在国内最先建立冷冻干燥骨库……。     

The ameliorating effect of oroxylin A on scopolamine-induced memory impairment in mice

Oroxylin A is a flavonoid and was originally isolated from the root of Scutellaria baicalensis Georgi., one of the most important medicinal herbs in traditional Chinese medicine. The aim of this study was to investigate the ameliorating effects of oroxylin A on memory impairment using the passive avoidance test, the Y-maze test, and the Morris water maze test in mice. Drug-induced amnesia was induced by administering scopolamine (1 mg/kg, i.p.) or diazepam (1 mg/kg, i.p.). Oroxylin A (5 mg/kg) significantly reversed cognitive impairments in mice by passive avoidance and the Y-maze testing (P<.05). Oroxylin A also improved escape latencies in training trials and increased swimming times and distances within the target zone of the Morris water maze (P<.05). Moreover, the ameliorating effects of oroxylin A were antagonized by both muscimol and diazepam (0.25 mg/kg, i.p., respectively), which are GABA(A) receptor agonists. Furthermore, oroxylin A (100 microM) was found to inhibit GABA-induced inward Cl(-) current in a single cortical neuron. These results suggest that oroxylin A may be useful for the treatment of cognitive impairments induced by cholinergic dysfunction via the GABAergic nervous system.