“就是给病人做了点东西”——访著名骨科专家卢世璧院士

翻开卢世璧院士的简历,一连串的首创性成果格外引人注目:在国内首先开展了人工关节的系列研究及临床应用;率先开展火器性周围神经伤的自体神经移植;首创形状记忆合金棒治疗脊柱侧弯;第一个研制成功国产关节连续被动活动器(CPM机);首先采用微波热疗治疗骨肿瘤;首先利用引导性组织再生概念进行长骨再生实验研究;在国内最先建立冷冻干燥骨库……。     

Visual working memory as the substrate for mental rotation

In mental rotation, a mental representation of an object must be rotated while the actual object remains visible. Where is this representation stored while it is being rotated? To answer this question, observers were asked to perform a mental rotation task during the delay interval of a visual working memory task. When the working memory task required the storage of object features, substantial bidirectional interference was observed between the memory and rotation tasks, and the interference increased with the degree of rotation. However, rotation-dependent interference was not observed when a spatial working memory task was used instead of an object working memory task. Thus, the object working memory subsystem—not the spatial working memory subsystem—provides the buffer in which object representations are stored while they undergo mental rotation. More broadly, the nature of the information being stored—not the nature of the operations performed on this information—may determine which subsystem stores the information.     

The ameliorating effect of oroxylin A on scopolamine-induced memory impairment in mice

Oroxylin A is a flavonoid and was originally isolated from the root of Scutellaria baicalensis Georgi., one of the most important medicinal herbs in traditional Chinese medicine. The aim of this study was to investigate the ameliorating effects of oroxylin A on memory impairment using the passive avoidance test, the Y-maze test, and the Morris water maze test in mice. Drug-induced amnesia was induced by administering scopolamine (1 mg/kg, i.p.) or diazepam (1 mg/kg, i.p.). Oroxylin A (5 mg/kg) significantly reversed cognitive impairments in mice by passive avoidance and the Y-maze testing (P<.05). Oroxylin A also improved escape latencies in training trials and increased swimming times and distances within the target zone of the Morris water maze (P<.05). Moreover, the ameliorating effects of oroxylin A were antagonized by both muscimol and diazepam (0.25 mg/kg, i.p., respectively), which are GABA(A) receptor agonists. Furthermore, oroxylin A (100 microM) was found to inhibit GABA-induced inward Cl(-) current in a single cortical neuron. These results suggest that oroxylin A may be useful for the treatment of cognitive impairments induced by cholinergic dysfunction via the GABAergic nervous system.     

The effect of the NMDA receptor antagonist MK-801 on the acquisition and extinction of learned fear in the developing rat

Recent findings reveal qualitative developmental differences in extinction of learned fear. The present study explored potential developmental differences in the role of NMDA in acquisition and extinction. Rats were injected with MK-801 prior to fear conditioning or extinction training. Acquisition was found to be NMDA dependent in both age groups, whereas extinction was found to be NMDA dependent in 23-day-old rats, but NMDA independent in 16-day-old rats. These results illustrate another fundamental developmental difference in extinction as well as a dissociation in the role of NMDA in the acquisition and extinction of fear early in development.     

Virtual environment training system for rehabilitation of stroke patients with unilateral neglect: crossing the virtual street.

In this paper, we propose a system for training of stroke patients with unilateral neglect by using technology of virtual reality (VR). The proposed system is designed to compensate for unilateral neglect. This system contains the calibration of unilateral neglect and the training of this disease. The calibration procedure is implemented by aligning the virtual object at a subjective middle line. The training procedure is implemented by completing the missions that are used to keep the virtual avatar safe during crossing the street in a virtual environment. The results of this study show that the proposed system is effective to train unilateral neglect. The left to right ratio scores extracted from this system gradually decrease as the sessions of training are repeated. To validate the VR system parameters, the parameters are analyzed by correlation with those of traditional unilateral neglect assessment methods (such as the line bisection test and the cancellation test).     

工作记忆中的注意焦点转换

在工作记忆中的选择性注意及注意焦点机制的基础上,从3个方面回顾了对工作记忆中注意焦点转换的研究：（1）工作记忆中的注意焦点转换的概念及其基本研究方法;（2）影响注意焦点转换代价的因素,包括提取、复述、加工、更新和记忆集大小等;（3）注意焦点转换与工作记忆各功能成分之间的关系,包括注意焦点转换与工作记忆执行功能的关系,注意焦点转换反映的存储、加工和执行功能之间的相互关系,注意焦点转换与工作记忆中资源分配的关系。最后,该文展望了未来的研究方向     

Delinquent peer affiliation and conduct problems: A twin study

Many putative environmental risks correlate with individuals' genotypes. The association between delinquent peer affiliation and conduct problems may occur because of shared genetic liability. Five hundred fifty three monozygotic and 558 dizygotic twin pairs, aged 11 to 18 years, were assessed for delinquent peer affiliation and conduct problems. The authors investigated whether genes contribute to both delinquent peer affiliation and the correlation between delinquent peer affiliations and conduct problems. Delinquent peer affiliation was influenced by genetic, shared environmental, and nonshared environmental factors; genetic factors also contributed to the correlation between delinquent peer affiliations and conduct problems, providing evidence for genotype-environment correlation. The magnitude of the genetic variance of conduct problems was contextually dependent on levels of delinquent peer affiliation and was greater at higher levels of delinquent peer affiliation.     

父母-儿童共同活动中的互动与儿童的数学学习

本研究运用结构性观察方法对两组4岁儿童与父母在四种活动中的互动进行了分析与比较。一组儿童为书面数符号测查高分者,二组儿童为书面数符号测查低分者。85对父母一儿童对子参加了4个各有15分钟的共同活动,阅读、数学题、纸和积木,并完成一个微型问卷。结果表明,在这些活动中包含了多种数学知识学习和多种以父母为主导的互动策略;两组对子之间在数学事件频次上无差异,但一组父母更多地运用了一些积极策略,二组父母更多地运用了一些消极策略;二组中有更多儿童对互动表现出消极回应和注意力问题。两个组的父母在家中与儿童一起进行诸如阅读和做数学题的共同活动的频次与质量上表现出差异。     

大学生人格、社会支持与主观幸福感的关系

采用问卷调查法探讨了大学生的主观幸福感与人格、社会支持的关系。研究发现：（1）大学生的主观幸福感无性别差异;（2）不同人格类型的大学生的主观幸福感水平有显著的差异：多血质者主观幸福感最高,抑郁质者最低;(3)四种人格类型大学生的主观幸福感均有随社会支持水平的增加而增加的趋势;（4）神经质、外向性和家庭外源性社会支持对主观幸福感有较强的预测力;但外向性与主观幸福感的关系将在一定程度上以家庭外源性社会支持为中介。     

文本阅读中预期推理激活与编码的语境条件研究

本研究通过三个实验考察了语义联系和因果制约对文本阅读中预期推理激活和编码的贡献。结果表明,预期语境与预期事件间的语义联系不能使预期推理在文本阅读过程中得到激活和编码,语境与预期事件间的强因果关系是文本阅读过程中预期推理激活与编码的必要条件;提示阅读过程中的预期是因果预期而非联想预期。结果为建构主义推理观提供了实验依据。