Teaching spontaneous requests to children with autism using a time delay procedure with multi-component toys

Children with autism were taught spontaneous requests through a time delay procedure. Unlike previous research, which usually employed food as the target stimuli to be requested, the present study used toy pieces from multi-component toys. The procedure involved presenting a child with the target stimulus, with the trainer prompting the child by immediately modeling the request response. When the response was imitated without error, prompting was delayed with the time interval gradually being increased over trials. A spontaneous or imitated response was reinforced by giving the child the requested object. As the stimulus/model interval increased, children with autism were expected to initiate the request by themselves prior to the prompt. The efficacy of the time delay procedure was assessed using a multiple baseline across subject design with three Chinese boys with autism. Results showed that the three children acquired a 100% performance within five to nine sessions of training and the skill was maintained at the one-month and three-month followups. Furthermore, the learned response transferred to various conditions when tested across setting, person, toy, and food items. These results suggest that toys, the multi-component ones in particular, served well as reinforcers for language training. Furthermore these findings confirmed the practical utility of the time delay procedure for promoting spontaneous communication skills in children with autism.     

The Parieto-Frontal Integration Theory (P-FIT) of intelligence: converging neuroimaging evidence

"Is there a biology of intelligence which is characteristic of the normal human nervous system?" Here we review 37 modern neuroimaging studies in an attempt to address this question posed by Halstead (1947) as he and other icons of the last century endeavored to understand how brain and behavior are linked through the expression of intelligence and reason. Reviewing studies from functional (i.e., functional magnetic resonance imaging, positron emission tomography) and structural (i.e., magnetic resonance spectroscopy, diffusion tensor imaging, voxel-based morphometry) neuroimaging paradigms, we report a striking consensus suggesting that variations in a distributed network predict individual differences found on intelligence and reasoning tasks. We describe this network as the Parieto-Frontal Integration Theory (P-FIT). The P-FIT model includes, by Brodmann areas (BAs): the dorsolateral prefrontal cortex (BAs 6, 9, 10, 45, 46, 47), the inferior (BAs 39, 40) and superior (BA 7) parietal lobule, the anterior cingulate (BA 32), and regions within the temporal (BAs 21, 37) and occipital (BAs 18, 19) lobes. White matter regions (i.e., arcuate fasciculus) are also implicated. The P-FIT is examined in light of findings from human lesion studies, including missile wounds, frontal lobotomy/leukotomy, temporal lobectomy, and lesions resulting in damage to the language network (e.g., aphasia), as well as findings from imaging research identifying brain regions under significant genetic control. Overall, we conclude that modern neuroimaging techniques are beginning to articulate a biology of intelligence. We propose that the P-FIT provides a parsimonious account for many of the empirical observations, to date, which relate individual differences in intelligence test scores to variations in brain structure and function. Moreover, the model provides a framework for testing new hypotheses in future experimental designs.     

国内外预立医疗照护计划社会经济效益的探讨

从卫生经济学视角,探讨预立医疗照护计划的社会经济效益。通过分析预立医疗照护计划的卫生经济政策、经济分析模式及社会经济效益评价研究等发现,预立医疗照护计划具有较明显的社会经济效益。借鉴国外经验和结合我国文化背景提出预立医疗照护计划在我国发展的对策和建议,包括建立相关政策突破发展障碍;构建激励制度,加强人才培养以支撑预立医疗照护计划发展;开展评价预立医疗照护计划经济效益的研究,以价值为导向构建本土化的医疗模式,以期为我国发展预立医疗照护计划的卫生经济学研究领域提供理论依据。

     

FDA儿童药物临床试验规范化对我国的启示

对美国食品药品监督管理局（Food and Drug Administration,FDA）儿童药物临床试验的规范化进行界定,发现我国面临儿童用药方面存在安全隐患、儿童药物临床试验存在需求缺口、儿童药物临床试验审查不够规范等现实困境,引发规范儿童药物临床试验的关键性思考。借鉴FDA对儿童药物临床试验的规范化实践,总结FDA儿童药物临床试验相关法案、临床试验指南文件以及对伦理审查委员会的监管措施,得出完善儿童药物临床试验专门法规和指南、加强相关伦理委员会监管和指导、规范儿童药物临床试验伦理审查、加大儿童受试者保护力度等对我国的启示。

     

Selfish power and unselfish status in Chinese work situations

The present research explored the selfishness of power and status as well as the mechanism in Chinese work situations. By using experimental and survey methods, two studies were designed to investigate the relationships among power, status, and self‐interested behaviour (SIB) as well as the mediating effect of perspective‐taking (PT). Results of the two studies consistently indicated that power increases whereas status reduces SIB. These opposing behavioural effects are partially attributed to the fact that power reduces whereas status increases PT. In addition, our results showed an interaction between power and status on SIB in Study 1 (interaction as a mental function), and a positive correlation between perceived power and status in Study 2 (correlation as a mental perception). Through the discussion from the perspective of the self/other‐orientation trait, as well as the stable effects of power and status on SIB in the two studies, we conclude that power is selfish and status is unselfish in Chinese work situations.     

Cross-lagged Models of Marital Relationships and Intergenerational Conflicts during Transition to Parenthood: Effect of Patrilineal Coresidence

The transition to parenthood is one of the most stressful intra- and interpersonal adjustment periods for new parents. Bidirectional associations among intergenerational relationships during the transition to parenthood have received limited attention, and the complexity of reciprocal relationships varies in accordance with living arrangements. The objectives of this study were to explore (1) the bidirectional associations between marital relationships and conflicts with in-laws during the transition to parenthood and (2) the moderation of patrilineal coresidence on the aforementioned relationships. A three-wave prospective longitudinal design was adopted for 359 married mothers. The Dyadic Adjustment Scale and Stryker Adjustment Checklist were used to assess marital relationships and conflicts with parents-in-law. Cross-lagged panel analysis was applied to examine reciprocal relationships, and multigroup analyses were employed to determine whether these relationships exhibited different patterns in accordance with the individuals’ living arrangements. The two cross-lagged models revealed the presence of a bidirectional relationship between marital distress and conflicts with parents-in-law during the mid- to late pregnancy stages. Meanwhile, the multigroup analyses suggested that conflicts with parents-in-law triggered marital distress during pregnancy in the coresidence group, whereas conflicts with fathers-in-law could intensify marital distress during late pregnancy to the postpartum period in the noncoresidence group. These findings shed light on cross-lagged associations with intergenerational conflicts. Healthcare professionals need to ensure that intergenerational relationships are positive during the transition to parenthood. This study enriches our understanding of the effect of patrilineal coresidence and can guide the future development of interventions based on culturally specific multidimensional approaches.     

Belief in Hell and Parenting Priorities Concerning Child Independence and Obedience: Does Economic Context Matter?

This study examines the ways that belief in hell is associated with parental goals concerning child independence and obedience. Further, it assesses how this association is contingent upon economic circumstances of a nation, reflected by a country's Gross Domestic Product (GDP) per capita. Multilevel analyses with data from the sixth wave of the World Values Survey (2010-2014) show that belief in hell is associated with a greater likelihood of opposing independence and endorsing obedience. Yet, these observed associations differ across national economic context. Specifically, the negative association between belief in hell and parental endorsement of independence is greater in countries that are more economically developed. Similarly, the positive association between belief in hell and parental endorsement of obedience is greater in countries that are more economically developed. The theoretical implications of these findings are discussed regarding the interplay of religion, parental values about child socialization, and social context.     

Bilateral Transcranial Direct Stimulation Over the Primary Motor Cortex Alters Motor Modularity of Multiple Muscles

Abstract

Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) has been demonstrated to modulate the motor performance of both healthy individuals and patients with neuromuscular disorders. However, the effect of tDCS on motor control of multiple muscles, which is a prerequisite to change in motor performance, is currently unknown. Using dimensionality reduction analysis, we investigated whether bilateral tDCS over M1 modulates the coordinated activity of 12 muscles. Fifteen healthy men participated in this randomized, double-blind crossover study. Each participant received a 20-min sham and 2-mA stimulation bilaterally over M1 (anode on the right M1 and cathode on the left M1), with a minimum washout period of 4?days. Muscle activation and end-point kinematics were evaluated during a task where participants reached out to a marked target with non-dominant hand as fast as possible, before and immediately after tDCS application. We found decreased similarity in motor modularity and significant changes in muscle activation in a specific motor module, particularly when reaching out to a target placed within arm’s length and improved smoothness index of movement only following 2-mA stimulation. These findings indicate that clinicians and researchers need to consider the simultaneous effect of bilateral tDCS over M1 on multiple muscles when they establish tDCS protocol to change in motor performance of patients with neuromuscular deficits.