Learning strategy selection in the water maze and hippocampal CREB phosphorylation differ in two inbred strains of mice

Learning strategy selection was assessed in two different inbred strains of mice, C57BL/6 and DBA/2, which are used for developing genetically modified mouse models. Male mice received a training protocol in a water maze using alternating blocks of visible and hidden platform trials, during which mice escaped to a single location. After training, mice were required to choose between the spatial location where the platform had been during training (a place strategy) and a visible platform presented in a new location (a cued/response strategy). Both strains of mice had similar escape performance on the visible and hidden platform trials during training. However, in the strategy preference test, C57BL/6 mice selected a place strategy significantly more often than DBA/2 mice. Because much evidence implicates the hippocampus and striatum as important neural substrates for spatial/place and cued/response learning, respectively, the engagement of the hippocampus was then assessed after either place or cue training by determining levels of cAMP response element-binding protein (CREB) and phosphorylated CREB (pCREB) in these two mouse strains. Results revealed that hippocampal CREB levels in both strains of mice were significantly increased after place in comparison to cued training. However, the relation of hippocampal pCREB levels to training was strain dependent; pCREB was significantly higher in C57BL/6 mice than in DBA/2 mice after place training, while hippocampal pCREB levels did not differ between strains after cued training. These findings indicate that pCREB, specifically associated with place/spatial training, is closely tied to differences in spatial/place strategy preference between C57BL/6 and DBA/2 mice.     

心灵观念的祛魅

通过一项疫苗临床试验国际合作项目的实施,讨论了如何在科学研究中贯彻落实GCP。结果表明,ICH提出的13项GCP指导原则在疫苗临床试验中得到了充分的实施。GCP不仅是临床试验的管理和指导原则,同时也保护研究对象的权利、保证资料的可信和自觉遵守标准操作程序（SOP）的意识。     

语素意识、语音意识和快速命名在学前儿童言语能力发展中的预测作用:来自追踪研究的证据*

为探讨语素意识、语音意识和快速命名三种认知技能对汉语儿童口语词汇、汉字识别和阅读理解等言语能力发展的预测作用,本研究对74名学前儿童进行了一年半的追踪测查,结果发现:(1) 学前儿童的各项认知技能和言语能力随时间均有显著提高;(2)在控制了因变量的自回归效应和其他两种认知技能后,语音意识对一年半后的口语词汇成绩仍有独特的解释作用,快速命名能预测一年半后的汉字识别成绩,而语素意识是解释一年半后儿童汉字识别和阅读理解能力发展的重要变量。     

执业医师执业权利内容概论

执业权是执业医师享有的法定权利之一,但对执业权的具体内容尚缺乏较为系统的研究与认定.首次提出并论述执业权应该包括诊断权、治疗权、处方权、证明权、疾病调查与身体检查权、死亡确认权、终止治疗权等七项权利.     

试论医生医疗工作归因

借鉴目前归因理论研究的成果,重点探讨了医生医疗工作归因的含义、结构、作用及方法,提出医生应学会对自己医疗工作中的成败进行合理的归因,自觉地总结经验、汲取教训,不断取得医学事业上的成功.     

大学生精神信仰的现状研究

本研究首次关注大学生的精神信仰,通过问卷对1100名大学生调查,发现大学生精神信仰存在如下特点：社会信仰占优势,其次依次为实用信仰和超自然信仰;民族主义、生命崇拜和国家主义位居前三位,宗教信仰、金钱崇拜和神灵崇拜位居后三位。     

Ministry Demand and Stress Among Korean American Pastors: A Brief Report

This study examined the relationship between ministry demand and three outcome variables among a sample of 194 Korean American pastors. Results showed that the demands of boundary ambiguity and presumptive expectations were negatively associated with well-being and positively associated with symptomatic stress. There was no association with life satisfaction. Exploratory analyses showed significant cultural differences between this sample and a non-Korean sample regarding the construct of boundary ambiguity.     

The effects of torture‐related stressors on long‐term complex post‐traumatic symptoms in South Korean torture survivors

This study explored whether perceived distress from specific stressors during and after torture explain long‐term complex post‐traumatic symptoms of South Korean torture survivors. We conducted a cross‐sectional survey of survivors who had been tortured by the homeland regime from the 1970s to the 2000s. Data from 206 survivors were gathered by key informants using target sampling and snowballing techniques. Project staff designed scales to encompass the specific types of stressors related to torture techniques used in Korea. Frequencies and distress ratings of exposure to torture, post‐torture psychosocial stressors and physical damage related to torture were gathered. Psychological symptoms were assessed by the Impact of Event Scale‐Revised‐Korean version and subscales of the Symptom Checklist 90‐Revised‐Korean version. Perceived distress from torture stressors was mainly divided into factors representing physical, psychological and deprivation torture by adapting a principal axis factor analysis. Hierarchical regression analyses showed that distress from psychological torture explained post‐traumatic stress disorder (PTSD) and that distress from deprivation explained PTSD and anxiety after controlling for demographic variables, psychological preparedness, time span since torture and distress from trauma other than torture. Among post‐torture stressors, distress from physical damage related to torture and social exclusion were strong indicators of complex symptoms.