Clinicopathological findings of suicide in the elderly: three cases

The neuropathological correlates of suicide in older persons have received little research attention. Our recent study of elderly suicide victims from an Australian forensic medicine department (n = 143), unlike a previous case-control study, did not find an increased prevalence of Alzheimer's disease (AD) in older persons who committed suicide despite a history of dementia in 6.3%. Both studies were limited to the examination of AD-related pathology by the availability of tissue. We present clinicopathological data on three cases from our study for whom autopsy findings were available. These cases included: a community-dwelling male in his early eighties with dementia who was found to have multiple cortical and striatal lacunes and glial scars, small vessel cerebrovascular disease (SVD) and AD-related pathology; a community-dwelling male in his mid-seventies with depression and loss of concentration, with brainstem predominant Lewy body disease (LBD) and AD-related pathology; and a female nursing home resident in her nineties with a history of stroke and prior suicide attempts who was found to have infarcts and SVD in frontal regions. Neuropathological findings in elderly suicide victims may include multiple neurodegenerative pathologies. The burden and distribution of neurodegenerative diseases apart from AD, including SVD and LBD, should be assessed as possible pathophysiological factors contributing to late life suicide.     

Love is Better than Knowledge: Paul,Luther and a Theology of Being Human

It is said in several contemporary theologies that in acting on their proclivities, homosexuals act as a law unto themselves rather than subordinate their desires to God's law. In linking homosexuality with the notion of a selfish individualism, these theologies cast homosexuals as incapable of exercising community-building love. They sustain a reductive model of the human person that issues from an anxiety about the presence of the “secular” ideology of individualism in theology. I suggest that we rehabilitate a vision of love based on a re-reading of the Apostle Paul's understanding of love as God-given and life-giving in 1 Corinthians and Romans, and use it as the basis for a revitalized vision of being human. Guided by Martin Luther's hermeneutic and contemporary thought, this vision recognizes the interdependent relationship between self- and other-concern, and proposes that we prioritize love over reductive knowledge claims in our theologies.     

Conditional discrimination in young children: the roles of associative and relational processing

Two experiments examined conditional discrimination in 4- to 6-year-olds. Children learned to choose one of two objects (e.g., circle) when the background was, say, red and to choose the other object (e.g., triangle) when the background was, say, blue. Awareness was assessed and interpreted as a marker of relational processing. In Experiment 1, most 4- and 5-year-olds did not reach the learning criterion. Children in Experiment 2 solved simpler reversal learning problems before the conditional discrimination problems. Most 4- to 6-year-olds reached criterion, but they did not necessarily demonstrate awareness, suggesting that reversal learning and conditional discrimination can be acquired through associative or relational processing. Relational processing increased with age and was used more on simpler problems. Fluid intelligence predicted Problem 2 performance in children who used relational (not associative) processing on Problem 1. Prior experience with simpler problems and awareness of relational structure are influential in children's conditional discrimination.     

Validity of the SDS-17 measure of social desirability in the American context

In Germany, Stober et al. (1999, 2001) presented evidence for the validity of the SDS-17, a new measure of social desirability bias. In the current investigation, three experiments (n = 800) assessed the SDS-17’s validity in the US environment. In all conditions SDS-17 scores correlated highly with Marlowe–Crowne scores. In Study 1, a group administration of a paper and pencil booklet, SDS-17 scores of 327 college students were higher under Fake Good than Standard conditions, and both were higher than scores in the Honest condition. Study 2, an online survey of a demographically diverse adult sample (n = 257), showed that the increase in SDS-17 scores under Fake Good conditions occurs also in a Web survey and that SDS-17 scores were unrelated to one’s demographic profile. Study 3, a group administration to 216 college students, revealed again that scores under Fake Good were higher than those under Standard administration and that SDS-17 scores correlated more highly with the Impression Management than with the Self-Deception subscales of the BIDR. The SDS-17 appeared valid for the US environment as a measure of socially desirable responding. The evidence, however, encourages its further assessment as an index of social desirability bias per se.     

Physiological evidence that a masked unrelated intervening item disrupts semantic priming: implications for theories of semantic representation and retrieval models of semantic priming

Event-related potentials were recorded in a paradigm where an unrelated word was interposed between two related words. In one condition, the intervening item was masked and in another condition it was not. The N400 component indicated that priming of the related word was disrupted by the intervening item whether it was masked or not. The data are interpreted to be inconsistent with retrieval models of priming.     

Hemisphere differences in conscious and unconscious word reading

Hemisphere differences in word reading were examined using explicit and implicit processing measures. In an inclusion task, which indexes both conscious (explicit) and unconscious (implicit) word reading processes, participants were briefly presented with a word in either the right or the left visual field and were asked to use this word to complete a three-letter word stem. In an exclusion task, which estimates unconscious word reading, participants completed the word stem with any word other than the prime word. Experiment 1 showed that words presented to either visual field were processed in very similar ways in both tasks, with the exception that words in the right visual field (left hemisphere) were more readily accessible for conscious report. Experiment 2 indicated that unconsciously processed words are shared between the hemispheres, as similar results were obtained when either the same or the opposite visual field received the word stem. Experiment 3 demonstrated that this sharing between hemispheres is cortically mediated by testing a split-brain patient. These results suggest that the left hemisphere advantage for word reading holds only for explicit measures; unconscious word reading is much more balanced between the hemispheres.     

The structure of childhood obsessions and compulsions: dimensions in an outpatient sample

While obsessive-compulsive disorder (OCD) is defined as a unitary condition, prior research has identified meaningful and distinct symptom dimensions in adult samples. In contrast, there have been no investigations of symptom dimensions in samples of children diagnosed with OCD. The present study sought to address this gap. Children diagnosed with OCD (n = 137) were administered the Children's Yale-Brown Obsessive-Compulsive Scale symptom checklist and severity index. Symptoms were analyzed using principal components analysis. As with adult samples, four factors were identified from the checklist. However, these four factors (compulsions, sexual/aggressive obsessions, superstitions, and hoarding/ordering/somatic concerns) were different in content from adult studies. Further, several symptoms significantly contributed to more than one dimension. Each dimension was significantly correlated with scores from the severity index, with the exception of the obsession score with the hoarding/ordering/somatic concerns factor. Results suggest that there are distinct dimensions of symptoms in childhood OCD, but that these dimensions do not correspond to those identified in adults. Instead, it appears that some factors share variance, and the dimensions themselves are separated based upon developmental trajectories. The dimensions examined may be useful in future treatment studies using pharmacological and/or behavioral interventions.     

Manipulability and living/non-living category effects on object identification

Object naming studies have generally observed that both normal and brain damaged individuals are faster and more accurate at identifying non-living objects than living objects (). However, a potential confounding variable, manipulability, has been present in past studies that may mediate this effect. Previous studies that have observed a non-living advantage have often used manipulable and non-manipulable exemplars to represent the non-living and living groups, respectively. Under conditions which controlled for object manipulability and familiarity, results demonstrated advantages for the identification of non-manipulable and for living objects.     

PTSD and Emotional Distress Symptoms Measured After a Motor Vehicle Accident: Relationships with Pain Coping Profiles

This study explored differences among pain patients classified as Dysfunctional, Interpersonally Distressed, and Adaptive Copers on the Multidimensional Pain Inventory with respect to PTSD symptomatology, anxiety, and depression. Eighty-five patients with pain complaints who had experienced a serious motor vehicle accident were classified into these three pain coping categories and assessed using clinician and self-report measures. Results indicated that patients classified as Adaptive Copers (n = 24) showed less PTSD symptomatology, anxiety, and depressed mood, relative to individuals classified as Dysfunctional (n = 36) and as Interpersonally Distressed (n = 25), who did not differ on these dimensions. Emotional responses during the accident (fear, helplessness, danger, perceived control, and certainty that one would die) did not differentiate the groups. Pain profiles contributed to the prediction of self-reported PTSD symptoms, controlling for state anxiety. These data suggest that pain patients with both Dysfunctional and Interpersonally Distressed coping profiles are at elevated risk for a range of posttrauma problems following a serious motor vehicle accident.