The Ophthalmic Experience: Unanticipated Primary Findings in the Era of Next Generation Sequencing

Next generation sequencing (NGS) technology, with the ability to sequence many genomic regions at once, can provide clinicians with increased information, in the form of more mutations detected. Discussions on broad testing technology have largely been focused on incidental findings, or unanticipated results related to diseases beyond the primary indication for testing. By examining multiple genes that could be responsible for the patient’s presentation, however, there is also the possibility of unexpected results that are related to the reason genetic testing was ordered. We present a case study where multiple potentially causative mutations were detected using NGS technology. This case raises questions of scientific uncertainty, and has important implications for medical management and secondary studies. Clinicians and genetic counselors should be aware of the potential for increased information to affect one’s understanding of genetic risk, and the pre- and post-testing counseling process.     

The Inner World of the First Half of Life: Analytical Psychology's Forgotten Developmental Stage

The field of analytical psychology has largely ignored the developmental stage that Jung termed the “first half of life.” As a result, a great many individuals coming of age today, starving for guidance on how to live in relationship to their inner lives, find little that reflects them within the Jungian literature or community. This article addresses that issue, identifying some of the challenges that individuals in the first half of life face today, including the lack of traditional supports to guide their transition from childhood into adulthood, and the popularly termed “quarter-life crisis” that often marks this stage. This article also questions the assumptions within the field that tie individuation to the second half of life, and it explores the relationship with the inner world that is possible earlier in life.     

Losing hope: mental health and religious service non-attendance in Australia

Religious beliefs and practices are related to mental health. Many individuals report a religious affiliation, but do not have specific religious beliefs or practices such as attending religious services. These non-attendees are often assumed to resemble the non-religious, but are poorly studied. This study explored the demographic characteristics and mental health outcomes associated with being a non-attendee using data from a nationally representative Australian sample. Non-attendees were more likely to be non-Christian than attendees at religious services. They had worse mental health than both non-religious individuals and attendees, especially compared to the non-religious. Whether non-attendance is a result of or cause of poor mental health outcomes is not clear and deserves further investigation. Non-attendees clearly differed in our sample from both non-religious individuals and attendees. Our results do not support the hypothesis that individuals who report a religious affiliation, but are not actively religious, are similar to non-religious individuals.     

“I Suck at Everything”: Crime,Arrest, and the Generality of Failure

In this article, we advance the idea that getting arrested amounts to “failing at crime.” And akin to the notion of the generality of deviance—where those who engage in any given form of criminal behavior are also likely to engage in a wide array of other problematic behaviors—we examine whether failing at crime (getting arrested) is associated with other forms of life failure. Using data from multiple waves of the National Longitudinal Study of Adolescent to Adult Health, our results reveal that, independent of one’s level of self-reported criminal behavior and other key potential confounders (IQ and self-control), being arrested is a significant predictor of a host of life failures related to education, employment, relationships, and health. The key implication of our study is that it highlights the need to develop a theory of the “generality of failure.”     

The Role of BIS Sensitivity in the Relationship Between Family Enmeshment and Child Anxiety

Previous work has demonstrated that three overarching vulnerabilities–genetic, environmental, and temperamental–contribute to the development of child anxiety. The purpose of our study was to assess: (a) the relationship between an environmental vulnerability, family enmeshment, and child anxiety; (b) whether parental anxiety accounts for this relationship; and (c) whether this relationship is mediated by levels of child Behavioral Inhibition System sensitivity, a highly persistent temperamental variable demonstrating positive associations with child anxiety. Our study included 38 Canadian parent–child dyads from an urban area, of which 33 children were Caucasian and 18 were girls. Children were aged 9 or 11 years (M = 10.21, SD = 1.07). Children completed measures of anxiety and sensitivity towards threat and parents completed measures of family enmeshment. The results supported a significant positive relationship between family enmeshment and child anxiety; parental anxiety did not account for this relationship; and the relationship was partially mediated by Behavioral Inhibition System sensitivity. Specifically, when the effect of Behavioral Inhibition System sensitivity was controlled for, the association between family enmeshment and child anxiety became non-significant. The results suggest that family enmeshment is associated with levels of child anxiety largely through the function of children’s sensitivity to threat. Enmeshed families may increase children’s susceptibility to anxiety through their effect on child temperament, specifically sensitivity to threat.     

Relationships among self-esteem, stress, and physical activity in college students

The purpose of this study was to identify population and sex-specific relationships between perceived stress, self-esteem, and physical activity in college students. 90 students, ages 18 and older and enrolled in five sections of a health and human behavior class during the spring 2010 semester, were contacted for this study with 74 consenting to serve as study participants. Each participant completed three surveys: the Rosenberg Self-Esteem Scale, the Perceived Stress Scale, and the International Physical Activity Questionnaire. Significant correlations were observed between perceived stress and self-esteem in men, and in women. Physical activity was not significantly correlated with perceived stress or self-esteem.     

The influence of facial masculinity and voice pitch on jealousy and perceptions of intrasexual rivalry

The assessment of same-sex individuals as intrasexual competitors may depend in part on the perceived mate value of potential rivals. Men’s and women’s preferences for vocal and facial masculinity suggest that feminine women and masculine men may be perceived as more threatening intrasexual competitors. We tested the influence of men’s and women’s vocal and facial masculinity on preferences for who should accompany romantic partners on a weekend trip and on jealousy in response to imagined flirting. We found that men and women preferred their partners to be accompanied by people who had less masculine/feminine voices, and were more jealous in response to people who had relatively more masculine/feminine voices. Women, but not men, rated faces with exaggerated sex-typical characteristics as undesirable travel companions for their romantic partners and reported more jealousy in response to imagined flirting from such faces. We also found that participants who rated masculine male and feminine female stimuli as more attractive also perceived such stimuli as greater intrasexual threats, demonstrating individual differences in competition-related social perceptions. Our findings indicate that perceptions related to intrasexual competition are related to cues to underlying mate quality, which may aid in effective mate guarding.     

Self-blame attributions,control appraisals and distress among cardiac rehabilitation patients

This study examined associations between self-blame attributions, control appraisals and distress among cardiovascular disease patients participating in a cardiac rehabilitation (CR) programme. Questionnaire data were collected from 129 patients at the beginning and end of CR. We found little evidence that characterological self-blame (CSB) affects distress symptoms, but behavioural self-blame at the beginning of CR was positively associated with distress symptoms concurrently, and 12 weeks later. Furthermore, diet- and exercise-focused self-blame was only modestly, positively related to control appraisals concurrently, while CSB was negatively associated with control. Prospectively, we found few significant associations between self-blame and control. Results imply that making any type of self-blame attribution during CR does not aid in adjustment or enhanced control appraisals. Our findings suggest that CR staff should encourage patients to recognise their control over reducing risk for recurrence, but should discourage patients from looking backward and ruminating about factors that may have contributed to disease onset.