The role of attentional biases in PTSD: is it interference or facilitation?

Although attentional biases have been demonstrated in individuals with posttraumatic stress disorder (PTSD), the cognitive methodologies used have not allowed for disambiguation of two types of attentional biases. It remains unclear if PTSD involves difficulty disengaging attention from threatening stimuli (interference) or facilitated detection. To differentiate between attentional interference and facilitation, 57 male Vietnam-era veterans (30 High PTSD and 27 Low PTSD) completed a visual search task with a lexical decision component. High PTSD veterans who engaged in the interference task first showed increased interference to threat-relevant words relative to Low PTSD veterans. However, no evidence was found for facilitated detection of threatening stimuli in PTSD.     

What exactly is a yait anyway: The role of semantics in orthographic learning

This study investigated whether semantic information presented along with novel printed nonwords facilitates orthographic learning and examined predictors of individual differences in this important literacy skill. A sample of 35 fourth graders was tested on a variety of language and literacy tests, and participants were then exposed to 10 target nonwords, 5 of which were presented with semantic information. Children were tested 1 and 4 days later on their ability to correctly recognize and spell the target nonwords. Results revealed a significant main effect on the recognition task, where items presented with semantic information were identified correctly more often than were words presented in isolation. No significant effect of training condition was found for the spelling posttests. Furthermore, multiple regression analyses revealed that both phonological and semantic factors were significant predictors of orthographic learning. The findings support the view that orthographic learning, as measured through visual recognition, involves the integration of phonological, orthographic, and semantic representations.     

If you want to know, consider asking: how likely is it that patients will hurt themselves in the future?

Although self-harming behavior is a common and costly problem for psychiatric inpatients released from the hospital, standardized tools that assess patients' risk for self-harm are rarely used in clinical settings. In this study of dually diagnosed psychiatric inpatients (N = 147), we assessed the utility of patients' self-perceptions of risk in predicting self-harm in the community. Patients' self-perceptions of risk predicted self-harm 8 weeks after discharge from the hospital (Lag 1; area under the curve [AUC] = 0.75). Self-perceptions of risk at the 8-week interview also predicted self-harm 2 months later (Lag 2; AUC = 0.72). Self-perceived risk added predictive utility above and beyond scores on a measure of depression and seemed to capture changes in risk state over time. The results suggest that inpatients can accurately perceive their own risk and therefore may be important collaborators in the risk management process.     

Glucocorticoids are required for extinction of predator stress-induced hyperarousal

Background

The role of glucocorticoids in extinction of traumatic memories has not been fully characterized despite its potential as a therapeutic target for acquired posttraumatic stress disorder (PTSD). The predator stress paradigm allows us to determine whether glucocorticoids mediate the extinction of both context-dependent and context-independent fear memories.

Methods

Male C57BL/6J mice were exposed to a predator (cat) then repeatedly exposed to the predator stress context in the absence of the cat. Context-dependent (associative) fear memory was assessed as suppression of activity during re-exposure to the predator stress context without the cat (extinction trials). Context-independent fear (non-associative) was assessed seven days after extinction trials using measures of hyperarousal and anxiety-like behaviours in environments unlike the predator stress context. To assess the role of glucocorticoids, mice were injected with metyrapone (50 mg/kg) 90 min prior to extinction trials in predator stressed mice and context-dependent and context-independent fear memories were assessed. Finally, metyrapone-treated predator stressed mice were injected with corticosterone (5 or 10 mg/kg) immediately following extinction trials and context-dependent and context-independent fear memories were assessed.

Results

Repeated re-exposure to the predator stress context without the cat present extinguished context-dependent fear memory, and also reduced hyperarousal, a generalized, chronic PTSD-like symptom. We show that extinction of context-independent predator stress-induced hyperarousal is dependent on endogenous glucocorticoids during the extinction trials. Furthermore, the inhibition of extinction by metyrapone on startle amplitude was reduced by exogenous administration of corticosterone following extinction trials. Overall, these data implicate glucocorticoids in the extinction of hyperarousal, a core symptom of PTSD.     

Situational and Individual Influences on Judgments of Hostile Environment Sexual Harassment1

The current research examines the judgment processes of third-party evaluators of sexual harassment situations. Four situational variables were hypothesized to influence ratings of situation appropriateness and judgments of sexual harassment. The evaluator's gender and personality also were hypothesized to influence both ratings. Participants were 73 male and 51 female undergraduate students. Results indicated that behavior severity and victim response significantly influenced ratings. The frequency of the behavior influenced appropriateness ratings, but interacted with behavior severity for harassment judgments. The effects of the gender of the evaluator were mediated by the evaluator's level of tolerance for harassment. The effects of the power relationship and rater personality were not significant.     

Examining approaches to encourage COVID-19 vaccination on social media

Following the release of the first COVID-19 vaccinations many people utilized social media to promote vaccination among their social circles. These attempts to persuade others to get vaccinated ranged from positive encouragement (e.g., emphasizing the prosocial benefits and positive outcomes) to shame and threats (e.g., name calling and threating to end friendships over vaccination status). The present study investigated how these different social media messages affected COVID-19 vaccination intentions. In June 2021, shortly after vaccines had been made freely available to anyone over the age of 16 in the United States, unvaccinated participants read a manipulated Twitter message designed to be either encouraging or shaming. Message-type did not significantly affect intentions to become vaccinated against COVID-19; however, participants who saw the encouraging message reported that the post made them feel more likely to get vaccinated. Self-efficacy was also manipulated but did not reveal any significant effects. Additional analyses suggest that having personal experience with COVID-19 moderates reactions to these different messages. We discuss limitations and promising avenues for future research on the effects of social media messages on health behaviors.     

Expanding retrieval practice: an effective aid to preschool children's learning

The benefits of expanding retrieval practice for preschool children were explored in two experiments. In Experiment 1, three groups learned names for six plush toy pigs using expanding retrieval practice, a reward incentive, or a control condition. Reward did not significantly improve learning but retrieval practice doubled recall. In Experiment 2, three groups learned names to soft toys, comparing recall following massed elaborative study with either expanding retrieval practice or expanding re-presentation. Recall was tested after 1 minute, 1 day, and 2 days. A very large effect size (d = 1.9) indicated the very considerable benefit from expanding retrieval practice over the elaboration condition. Comparison with the re-presentation condition suggested that half of the benefit of expanding retrieval practice came from spaced scheduling and half from retrieval practice. Expanding retrieval practice provides an effective method to improve learning by young children.     

The Ophthalmic Experience: Unanticipated Primary Findings in the Era of Next Generation Sequencing

Next generation sequencing (NGS) technology, with the ability to sequence many genomic regions at once, can provide clinicians with increased information, in the form of more mutations detected. Discussions on broad testing technology have largely been focused on incidental findings, or unanticipated results related to diseases beyond the primary indication for testing. By examining multiple genes that could be responsible for the patient’s presentation, however, there is also the possibility of unexpected results that are related to the reason genetic testing was ordered. We present a case study where multiple potentially causative mutations were detected using NGS technology. This case raises questions of scientific uncertainty, and has important implications for medical management and secondary studies. Clinicians and genetic counselors should be aware of the potential for increased information to affect one’s understanding of genetic risk, and the pre- and post-testing counseling process.     

“I Suck at Everything”: Crime,Arrest, and the Generality of Failure

In this article, we advance the idea that getting arrested amounts to “failing at crime.” And akin to the notion of the generality of deviance—where those who engage in any given form of criminal behavior are also likely to engage in a wide array of other problematic behaviors—we examine whether failing at crime (getting arrested) is associated with other forms of life failure. Using data from multiple waves of the National Longitudinal Study of Adolescent to Adult Health, our results reveal that, independent of one’s level of self-reported criminal behavior and other key potential confounders (IQ and self-control), being arrested is a significant predictor of a host of life failures related to education, employment, relationships, and health. The key implication of our study is that it highlights the need to develop a theory of the “generality of failure.”