Conscious recollection in autobiographical memory: an investigation in schizophrenia

Whether or not conscious recollection in autobiographical memory is affected in schizophrenia is unknown. The aim of this study was to address this issue using an experiential approach. An autobiographical memory enquiry was used in combination with the Remember/Know procedure. Twenty-two patients with schizophrenia and 22 normal subjects were asked to recall specific autobiographical memories from four lifetime periods and to indicate the subjective states of awareness associated with the recall of what happened, when and where. They gave Remember, Know or Guess responses according to whether they recalled these aspects of the event on the basis of conscious recollection, simply knowing, or guessing. Results showed that the frequency and consistency of Remember responses was significantly lower in patients than in comparison subjects. In contrast, the frequency of Know responses was not significantly different, whereas the frequency of patients' Guess responses was significantly enhanced. It is concluded that the frequency and consistency of conscious recollection in autobiographical memory is reduced in patients with schizophrenia.     

Indices of response bias in the same-different experiment

The same-different experiment is popular for assessing perceptual performance, including the performance of people with neuropsychological deficits. Although the measurement of accuracy with this experiment is now well understood, the measurement of response bias remains problematic. Reformulating the decision space for the experiment can yield new bias indices that are analogous to, but numerically different from, those of the more familiar yes-no experiment. Isobias curves that show how hit rate covaries with false alarm rate for constant bias but varying accuracy are presented for eight indices, and best-fitting parameters of the isobias functions are determined for a set of experimental data. The theoretical status of the bias indices and their relation to other formulations are reviewed.     

... In relation to medicine

Pastoral Psychology -     

Measures of information processing in rapid automatized naming (RAN) and their relation to reading

The letters, numbers, and objects subtests of the Rapid Automatized Naming Tests (RAN) were given to 50 first- and second-grade students. Student performance on the three RAN subtests were audiotaped and subjected to postacquisition processing to distinguish articulation and interarticulation pause times. This study investigated (1) the relations between the articulation and pause durations associated with the 50 stimuli of each RAN subtest and (2) the relations between the pause and articulation latencies of the three RAN subtests and reading. For both first- and second-grade students, pause and articulation times for RAN letters and objects were not found to be reliably related, in contrast to RAN numbers articulation and pause durations. RAN subtest pause durations were differentially related to reading; however, articulation was rarely related to reading. The RAN letters pause time was the most robust predictor of decoding and reading comprehension, consistently predicting all first- and second-grade measures. Analysis supported the view that reading is predicted by speed of processing associated with letters, not general processing speed.     

A role for ERK MAP kinase in physiologic temporal integration in hippocampal area CA1

Recent studies demonstrate a requirement for the Extracellular signal Regulated Kinase (ERK) mitogen-activated protein kinase (MAPK) cascade in both the induction of long-lasting forms of hippocampal synaptic plasticity and in hippocampus-dependent associative and spatial learning. In the present studies, we investigated mechanisms by which ERK might contribute to synaptic plasticity at Schaffer collateral synapses in hippocampal slices. We found that long-term potentiation (LTP) induced with a pair of 100-Hz tetani does not require ERK activation in mice whereas it does in rats. However, in mice, inhibition of ERK activation blocked LTP induced by two LTP induction paradigms that mimicked the endogenous θ rhythm. In an additional series of studies, we found that mice specifically deficient in the ERK1 isoform of MAPK showed no impairments in tests of hippocampal physiology. To investigate ERK-dependent mechanisms operating during LTP-inducing stimulation paradigms, we monitored spike production in the cell body layer of the hippocampus during the period of θ-like LTP-inducing stimulation. θ-burst stimulation (TBS) produced a significant amount of postsynaptic spiking, and the likelihood of spike production increased progressively over the course of the three trains of TBS independent of any apparent increase in Excitatory Post-Synaptic Potential (EPSP) magnitude. Inhibition of ERK activation dampened this TBS-associated increase in spiking. These data indicate that, for specific patterns of stimulation, ERK may function in the regulation of neuronal excitability in hippocampal area CA1. Overall, our data indicate that the progressive increase in spiking observed during TBS represents a form of physiologic temporal integration that is dependent on ERK MAPK activity.     

Crossmodal links between audition and touch in covert endogenous spatial attention

We report three experiments designed to investigate the nature of any crossmodal links between audition and touch in sustained endogenous covert spatial attention, using the orthogonal spatial cuing paradigm. Participants discriminated the elevation (up vs. down) of auditory and tactile targets presented to either the left or the right of fixation. In Experiment 1, targets were expected on a particular side in just one modality; the results demonstrated that the participants could spatially shift their attention independently in both audition and touch. Experiment 2 demonstrated that when the participants were informed that targets were more likely to be on one side for both modalities, elevation judgments were faster on that side in both audition and touch. The participants were also able to "split" their auditory and tactile attention, albeit at some cost, when targets in the two modalities were expected on opposite sides. Similar results were also reported in Experiment 3 when participants adopted a crossed-hands posture, thus revealing that crossmodal links in audiotactile attention operate on a representation of space that is updated following posture change. These results are discussed in relation to previous findings regarding crossmodal links in audiovisual and visuotactile covert spatial attentional orienting.     

Reliability of the Francis Scale of Attitude Toward Christianity among 8-yr-olds

The Francis Scale of Attitude Toward Christianity was completed by 78 8-yr.-olds (40 boys and 38 girls) whose data support reliability measured as the internal consistency of the scale for this young sample.     

Evaluation of six multinomial models of conscious and unconscious processes with the recall-recognition paradigm

Six multinomial processing-tree models (W. H. Batchelder & D. M. Riefer, 1999), which include parameters representing conscious and unconscious memory processes, were tested using the recall-recognition paradigm. Data from 2 experiments were fit equally well by 3 of the 6 models. One model recognition was an extension of the generate-recognize model (L. L. Jacoby, 1998), and another was an extension of the non-high-threshold model (D. M. McBride & B. A. Dosher, 1999). The 3rd model was the source evaluation model (D. M. McBride & B. A. Dosher, 1999). Values of the parameters of 2 of these 3 models, excepting the non-high-threshold model, responded to experimental manipulations in accordance with the meaning of the parameters. The equivalence of models with regard to goodness-of-fit tests is discussed as is how experiments can be designed to demonstrate the superiority of one model over another. The potential usefulness of these models in the study of amnesia is considered.     

Correlation between religion and happiness: a replication

For a sample of 89 students in Wales who completed the Oxford Happiness Inventory and the Francis Scale of Attitude Toward Christianity scores correlated .38.     

Reliability and construct validity for scale of rejection of Christianity

A sample of 16 male and 30 female undergraduates completed the Greer and Francis Scale of Rejection of Christianity. The data support the internal consistency reliability and construct validity of the scale for this sample.