Schizophrenia risk and paternal age: a potential role for de novo mutations in schizophrenia vulnerability genes

How schizophrenia (SZ) is maintained at roughly 1% of the population despite diminished reproduction is one puzzle currently facing researchers. De novo mutations were first proposed over half a century ago as a source for new SZ genes. Current evidence linking advancing paternal age to SZ risk makes revisiting this hypothesis important. Advancing paternal age is the major source of new mutations in the human population. This article will examine potential mechanisms whereby parental age may impact new mutations, as well as review recent data supporting such a hypothesis.     

How do children coordinate simultaneous upper and lower extremity tasks? The development of dual motor task coordination

When performing simultaneous clapping with walking or galloping, adults adopt coupled, consistent and stable dual motor task coordination; do developmental trends in this coordination exist? In this study, we measured and compared coupling characteristics, consistency across trials and variability of phasing in 4-, 6-, 8-, and 10-year-olds (n=44) as they also performed the same dual motor task. For walk/clap, children adopted specific coupling patterns like adults by 8 years and with the same consistency by 10 years. Across age, children became less variable in clap and step movements separately and as coupled together. In the gallop/clap, children did not resemble adults in coupling patterns by 10 years but all measures were becoming more consistent across age. We discuss dual motor task coordination as a function of age and task complexity using a "dynamic" perspective within a developmental context.     

A role for ERK MAP kinase in physiologic temporal integration in hippocampal area CA1

Recent studies demonstrate a requirement for the Extracellular signal Regulated Kinase (ERK) mitogen-activated protein kinase (MAPK) cascade in both the induction of long-lasting forms of hippocampal synaptic plasticity and in hippocampus-dependent associative and spatial learning. In the present studies, we investigated mechanisms by which ERK might contribute to synaptic plasticity at Schaffer collateral synapses in hippocampal slices. We found that long-term potentiation (LTP) induced with a pair of 100-Hz tetani does not require ERK activation in mice whereas it does in rats. However, in mice, inhibition of ERK activation blocked LTP induced by two LTP induction paradigms that mimicked the endogenous θ rhythm. In an additional series of studies, we found that mice specifically deficient in the ERK1 isoform of MAPK showed no impairments in tests of hippocampal physiology. To investigate ERK-dependent mechanisms operating during LTP-inducing stimulation paradigms, we monitored spike production in the cell body layer of the hippocampus during the period of θ-like LTP-inducing stimulation. θ-burst stimulation (TBS) produced a significant amount of postsynaptic spiking, and the likelihood of spike production increased progressively over the course of the three trains of TBS independent of any apparent increase in Excitatory Post-Synaptic Potential (EPSP) magnitude. Inhibition of ERK activation dampened this TBS-associated increase in spiking. These data indicate that, for specific patterns of stimulation, ERK may function in the regulation of neuronal excitability in hippocampal area CA1. Overall, our data indicate that the progressive increase in spiking observed during TBS represents a form of physiologic temporal integration that is dependent on ERK MAPK activity.     

Eating disorders and obesity

The majority of patients with eating disorders are female. Most of those seeking treatment for weight loss are also women. Our culture views slenderness as beautiful, creating pressure to be thin. For some, however, the pursuit of thinness may be a way to avoid difficult developmental tasks, increase self-acceptance or get approval from others. Whatever its purpose, seeking slimness can lead to health problems as a result of starvation, binging and purging, or rapid cycles of weight loss and gain. Starvation and the binge-purge cycle themselves also create psychological problems. In this article, the etiology, maintenance and treatment of anorexia nervosa and bulimia are discussed from a cognitive-behavioral perspective. Attention is given to the interplay of physical, psychological and behavioral aspects of these disorders. Although obesity is a physical condition, not an emotional disorder, many women are distressed over their size due to the influence of cultural demands for thinness. The psychotherapist working with weight control may face the dilemma of whether to help a woman accept herself at her size or lose weight. Some guidelines for making a decision are discussed. Cognitions impeding weight loss are identified, and advances in cognitive-behavioral weight loss treatment are discussed.Jill Bresler is a psychologist in private practice and is on staff at the Institute for Rational-Emotive Therapy, New York City     

All Absences Are Not the Same: What Happens to the Group Climate When Someone is Absent From Group?

Clinical wisdom dictates that group member absences are harmful to the group; however, this has not been empirically examined. How do group member absences affect the group’s climate, and do absences earlier or later in a group’s life differentially impact group climate? The current study examined the relationship between group member absence and the climate perceptions for attending members, during earlier and later sessions in a group’s development. As hypothesized, a significant interaction was found for group climate and time such that absences during early sessions were significantly related to higher levels of engagement and lower levels of avoidance (a more productive group atmosphere), while absences during later sessions were related to lower levels of engagement and higher levels of avoidance. Implications are discussed.     

Narrative Therapy's Relational Understanding of Identity

We describe how we think of identity as relational, distributed, performed, and fluid, and we illustrate the use of this conceptualization within a narrative worldview. Drawing on the work of Michael White, we describe how this relational view of identity leads to therapeutic responses that give value to interconnection across multiple contexts and that focus on becoming rather than on being. We show how a narrative worldview helps focus on the relational, co‐evolving perspective that was the basis of our early attraction to family therapy. We offer detailed examples from our work of practices that help us stay firmly situated in a relational worldview that is counter to the pervasive influence of individualism in our contemporary culture.