The Contribution of Neuroimaging to the Study of Language and Aphasia

New structural and functional imaging methods continue to be developed at a rapid pace. In the last 25 years, advanced imaging techniques have provided insights into how language is represented and processed in the brain and how it can be disrupted by damage to, or dysfunction of, various parts of the brain. Imaging studies have also yielded new information regarding how individuals recover language after stroke. We briefly review the strengths and weaknesses of the various radiological methods currently used to study language and aphasia.     

Phonological Assimilation and Visual Word Recognition

Are the visual word-processing tasks of naming and lexical decision sensitive to systematic phonological properties that may or may not be specified in the spelling? Two experiments with Hangul, the alphabetic orthography of Korea, were directed at the effects of the phonological process of assimilation whereby one articulation changes to conform to a neighboring articulation. Disyllabic words were responded to more quickly when (a) the final letter of the first syllable and the initial letter of the second syllable specified phonemes that satisfied rather than violated consonant assimilation, and (b) the vowel letters specified harmonious as opposed to disharmonious vowel phonemes. Discussion addressed the possible mediation of assimilation effects by consistency differences and theories that predict broad phonological influences on visual word recognition.     

Bayesian Analysis of Nonlinear Structural Equation Models with Nonignorable Missing Data

A Bayesian approach is developed for analyzing nonlinear structural equation models with nonignorable missing data. The nonignorable missingness mechanism is specified by a logistic regression model. A hybrid algorithm that combines the Gibbs sampler and the Metropolis–Hastings algorithm is used to produce the joint Bayesian estimates of structural parameters, latent variables, parameters in the nonignorable missing model, as well as their standard errors estimates. A goodness-of-fit statistic for assessing the plausibility of the posited nonlinear structural equation model is introduced, and a procedure for computing the Bayes factor for model comparison is developed via path sampling. Results obtained with respect to different missing data models, and different prior inputs are compared via simulation studies. In particular, it is shown that in the presence of nonignorable missing data, results obtained by the proposed method with a nonignorable missing data model are significantly better than those that are obtained under the missing at random assumption. A real example is presented to illustrate the newly developed Bayesian methodologies. This research is fully supported by a grant (CUHK 4243/03H) from the Research Grant Council of the Hong Kong Special Administration Region. The authors are thankful to the editor and reviewers for valuable comments for improving the paper, and also to ICPSR and the relevant funding agency for allowing the use of the data. Requests for reprints should be sent to Professor S.Y. Lee, Department of Statistics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.     

Cognitive processes that underlie mathematical precociousness in young children

The working memory (WM) processes that underlie young children's (ages 6-8 years) mathematical precociousness were examined. A battery of tests that assessed components of WM (phonological loop, visual-spatial sketch pad, and central executive), naming speed, random generation, and fluency was administered to mathematically precocious and average-achieving children. The results showed that (a) precocious children performed better on executive processing, inhibition, and naming speed tasks than did average-achieving children, although the two groups were statistically comparable on measures of the phonological loop and visual-spatial sketch pad, and (b) the executive component of WM predicted mathematical accuracy independent of chronological age, reading, inhibition, and naming speed. The results support the notion that the executive system is an important predictor of children's mathematical precociousness and that this system can operate independent of individual differences in the phonological loop, inhibition, and reading in predicting mathematical accuracy.     

The differential effects of thalamus and basal ganglia on facial emotion recognition

This study examined if subcortical stroke was associated with impaired facial emotion recognition. Furthermore, the lateralization of the impairment and the differential profiles of facial emotion recognition deficits with localized thalamic or basal ganglia damage were also studied. Thirty-eight patients with subcortical strokes and 19 matched normal controls volunteered to participate. The participants were individually presented with morphed photographs of facial emotion expressions over multiple trials. They were requested to classify each of these morphed photographs according to Ekman's six basic emotion categories. The findings indicated that the clinical participants had impaired facial emotion recognition, though no clear lateralization pattern of impairment was observed. The patients with localized thalamic damage performed significantly worse in recognizing sadness than the controls. Longitudinal studies on patients with subcortical brain damage should be conducted to examine how cognitive reorganization post-stroke would affect emotion recognition.     

Reorientation and landmark-guided search by young children: evidence for two systems

Disoriented 4-year-old children use a distinctive container to locate a hidden object, but do they reorient by this information? We addressed this question by testing children's search for objects in a circular room containing one distinctive and two identical containers. Children's search patterns provided evidence that the distinctive container served as a direct cue to a hidden object's location, but not as a directional signal guiding reorientation. The findings suggest that disoriented children's search behavior depends on two distinct processes: a modular reorientation process attuned to the geometry of the surface layout and an associative process linking landmarks to specific locations.