A systematic review of interventions for anxiety in people with HIV

People with human immunodeficiency virus (HIV) show elevated anxiety levels compared to the general population. Anxiety can predate HIV infection or be triggered by HIV diagnosis and the many stresses that emerge during the course of HIV disease. Many psychological and pharmacological therapies have been shown to treat anxiety in the general population but a systematic understanding of which interventions have been tested in and are effective with HIV-seropositive individuals is needed. This review examines all published intervention studies on anxiety and HIV from 1980 to 2009 covered by the databases MedLine (1980-2009) and PsycINFO (1980-2009) for a definitive account of effectiveness of interventions and an indication of prevalence of HIV-related anxiety and measurement within studies. Standard systematic research methods were used to gather quality published papers on HIV and anxiety, searching published data bases according to quality inclusion criteria. From the search, 492 papers were generated and hand searched resulting in 39 studies meeting adequacy inclusion criteria for analysis. Of these, 30 (76.9%) were implemented in North America (the USA and Canada), with little representation from developing countries. Thirty-three (84.6%) studies recruited only men or mostly men. A total of 50 interventions were investigated by the 39 studies; 13 targeted HIV, symptoms or associated outcomes/conditions, 20 directly targeted anxiety and another 17 indirectly targeted anxiety. Twenty-four (48%) interventions were effective in reducing anxiety (including 11 indirect interventions), 16 (32%) were ineffective and 10 (20%) had an unknown effect on anxiety. Sixty-five percent of interventions directly targeting anxiety were effective. Psychological interventions (especially cognitive behavioural stress management interventions and cognitive behavioural therapy) were generally more effective than pharmacological interventions. Only three studies provided prevalence rates - these ranged from 13% to 80%. Anxiety was measured using 16 different instruments. Our detailed data suggest that interventions are both effective and available, although further research into enhancing efficacy would be valuable. Also, the vast majority of studies were Western-based, no studies looked at children or adolescents and few looked specifically at women. An international effort to harmonise measurement of anxiety is also missing. There is a need to routinely log anxiety in those with HIV infection during the course of their disease, to provide specific data on women, young people and those in diverse geographic areas and incorporate management into care protocols.     

Emotional reactions to scandals: When does moral character make a difference?

A scandal can evoke public outrage when it is widely publicized and involves an individual who is perceived to have a high level of cultural representativeness. Two experiments showed that when the scandalous target's moral character was highlighted, emotional responses towards the target were least negative when the scandal was widely circulated and when the target was seen as a representative of his culture. These results suggest that when a cultural symbol is implicated in a widely‐circulated scandal, the negative emotions directed towards the scandalous individual can be alleviated when the public remains confident in his or her commitment to morality.     

超越效价和唤醒—— 情绪的动机维度模型述评

情绪的动机维度模型认为, 高动机强度的情绪窄化(narrow)认知加工而低动机强度的情绪扩展(broaden)认知加工。该理论超越了先前对效价和唤醒两大情绪维度的二分法, 证明了情绪的动机维度对注意、记忆等认知加工产生扩展和窄化效应, 深化了积极情绪的扩展-建设理论, 有助于深入理解情绪与认知的交互作用。未来研究应建立动机维度的操作性定义, 并进一步发展出诱发不同动机维度情绪的标准化刺激材料或任务。     

Higher‐Order Thought and the Problem of Radical Confabulation

Currently, one of the most influential theories of consciousness is Rosenthal's version of higher‐order‐thought (HOT). We argue that the HOT theory allows for two distinct interpretations: a one‐component and a two‐component view. We further argue that the two‐component view is more consistent with his effort to promote HOT as an explanatory theory suitable for application to the empirical sciences. Unfortunately, the two‐component view seems incapable of handling a group of counterexamples that we refer to as cases of radical confabulation. We begin by introducing the HOT theory and by indicating why we believe it is open to distinct interpretations. We then proceed to show that it is incapable of handling cases of radical confabulation. Finally, in the course of considering various possible responses to our position, we show that adoption of a disjunctive strategy, one that would countenance both one‐component and two‐component versions, would fail to provide any empirical or explanatory advantage.     

Zero Anaphora: Transfer of Reference Tracking Strategies from Chinese to English

English contains many nominals that would be absent in Chinese because Chinese makes greater use of zero anaphora, which is an empty grammatical slot in a sentence standing for a previously mentioned referent. Native Chinese and native English speakers were compared in comprehending modified English passages from a standardized reading test with nominals deleted that would be absent in Chinese. In three experiments, Chinese speakers showed superior comprehension as measured by objective multiple-choice questions in this case, but not when no words were deleted or when nominals were deleted that would not be absent in Chinese. These results imply that native Chinese speakers develop reference tracking strategies that they transfer to comprehending English.This research was supported in part by United States Army Research Institute Contracts MDA903-93-K-0010, DASW01-96-K-0010, DASW01-99-K-0002, and DASW01-03-K-0002 to the University of Colorado (Alice Healy, Principal Investigator).We thank Lyle Bourne and Barbara Fox for stimulating discussions about this research. We are also grateful to the Institute of Cognitive Science at the University of Colorado for their support of this research.Experiments 1 and 2 were reported at the International Conference on Functional Approaches to Grammar, Albuquerque, NM, July 25, 1995, and at the 37th Annual Meeting of the Psychonomic Society, Chicago, IL, November 3, 1996, and all three experiments were reported at the 2001 American Association for Applied Linguistics conference, St. Louis, MO, February 24, 2001.     

Nicotinic cholinergic synaptic mechanisms in the ventral tegmental area contribute to nicotine addiction

Tobacco use is a major health problem that is estimated to cause 4 million deaths a year worldwide. Nicotine is the main addictive component of tobacco. It acts as an agonist to activate and desensitize nicotinic acetylcholine receptors (nAChRs). A component of nicotine's addictive power is attributable to actions on the mesolimbic dopaminergic system, which serves a fundamental role in the acquisition of behaviors that are inappropriately reinforced by addictive drugs. Here we show that nicotine, in the same concentration and time ranges as obtained from tobacco, has three main actions that regulate the activity of midbrain dopamine (DA) neurons. Nicotine first activates and then desensitizes nAChRs on the DA neurons. This process directly excites the DA neurons for a short period of time before the nAChRs desensitize. Nicotine also enhances glutamatergic excitation and decreases GABAergic inhibition onto DA neurons. These events increase the probability for synaptic plasticity, such as long-term potentiation. The short-lived direct excitation of the DA neurons coupled with the enhanced glutamatergic afferent activity provides the presynaptic and postsynaptic coincidence necessary to initiate synaptic potentiation. In total, these synaptic events lead to a relatively long-lasting heightened activity of midbrain DA neurons. Consistent with other summarized studies, this work indicates that the synaptic changes normally associated with learning and memory can be influenced and commandeered during the nicotine addiction process.     

小学生阅读迁移机制的进一步研究--字词表征还是内容表征

探讨阅读文章难易程度与文章字词和内容在小学生篇章阅读迁移中的作用。被试分为阅读水平高、低两组。采用个别方式施测,以阅读时间和阅读准确性为阅读迁移的指标。结果表明,低水平组被试的篇章阅读迁移主要依赖词汇表征;高水平组被试的篇章阅读迁移主要依赖内容表征,换言之,容易文章主要以内容表征进行迁移;困难文章主要以词汇表征进行迁移。     

On local influence analysis of full information item factor models

The full information item factor (FIIF) model is very useful for analyzing relations of dichotomous variables. In this article, we present a feasible procedure to assess local influence of minor perturbations for identifying influence aspects of the FIIF model. The development is based on a Q-displacement function which is closely related with the Monte Carlo EM algorithm in the ML estimation. In the E-step of this algorithm, the conditional expectations are approximated by sample means of observations simulated by the Gibbs sampler from the appropriate conditional distributions. It turns out that these observations can be utilized for computing the building blocks of the proposed diagnostic measures. The diagnoses are based on the conformal normal curvature that can be computed easily. A number of interesting perturbation schemes are considered. The methodology is illustrated with two real examples.The research is fully supported by a grant (CUHK 4356/00H) from the Research Grant Council of the Hong Kong Special Administration Region. The authors are thankful to the Editor, Associate Editor, anonymous reviewers, and W.Y. Poon for valuable comments for improving the paper, and to ICPSR and the relevant founding agency for allowing us to use of their data. The assistance of Michael Leung and Esther Tam is gratefully acknowledged.     

几种时间表征的研究概况

概述时间表征外显与内隐的分类,对动力心理表征及表征动量的研究进行了讨论