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31.
方健 《医学与哲学(人文社会医学版)》2014,(11):20-23
恶性肿瘤的治疗已经进入驱动基因指导下的个体治疗时代,肺癌患者应该进行多基因检测,特别是表皮生长因子受体(EGFR)基因突变。EGFR基因突变的非小细胞肺癌(NSCLC)患者,如果一线接受了化疗,二线应该选择表皮生长因子受体一酪氨酸酶抑制剂(EGFR—TKIs)。EGFR基因突变的NSCLC患者一线EGFR—TKIs治疗失败后,二线治疗应该是个体化合理选择,包括局部放疗、化疗和继续EGFR—TKIs。目前一代和二代EGFR—TKIs药物之间未见到显著疗效差别。第三代EGFR—TKIs是目前的EGFR—TKIs耐药后的最有希望的选择,特别是针对T790M突变耐药。 相似文献
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以247名贫困儿童为被试进行问卷调查,构建家庭社会经济地位和亲子关系对贫困儿童问题行为的多重中介模型,得到抑郁、自我控制的中介作用。结果显示,亲子关系和社会经济地位分别通过中介路径影响贫困儿童问题行为,与亲子关系有关的中介路径为91.25%,与抑郁有关的中介效应为57.60%,与自我控制有关的中介效应为57.15%. 结论:良好的亲子关系或成为贫困儿童的保护因子;应关注贫困儿童心理健康,增加有效心理疏导机制;注重培养贫困儿童的自我控制能力。 相似文献
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Zhilin Zhang Chunlin Li Jian Zhang Qiang Huang Ritsu Go Tianyi Yan Jinglong Wu 《Attention, perception & psychophysics》2018,80(2):576-585
Humans exhibit a remarkable ability to discriminate variations in object volume based on natural haptic perception. The discrimination thresholds for the haptic volume perception of the whole hand are well known, but the discrimination thresholds for haptic volume perception of fingers and phalanges are still unknown. In the present study, two psychophysical experiments were performed to investigate haptic volume perception in various fingers and phalanges. The configurations of both experiments were completely dependent on haptic volume perception from the fingers and phalanges. The participants were asked to blindly discriminate the volume variation of regular solid objects in a random order by using the distal phalanx, medial phalanx, and proximal phalanx of their index finger, middle finger, ring finger, and little finger. The discrimination threshold of haptic volume perception gradually decreases from the little finger to the index finger as well as from the proximal phalanx to the distal phalanx. Overall, both the shape of the target and the part of the finger in contact with the target significantly influence the precision of haptic perception of volume. This substantial data set provides detailed and compelling perspectives on the haptic system, including for discrimination of the spatial size of objects and for performing more general perceptual processes. 相似文献
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以新生代农民工为研究对象,以其对群际通透性的感知为测量指标,检验积极群际接触的有效性,探察群体受害者身份感知和群体认同对积极群际接触有效性的影响,以及群体认同在群体受害者身份感知与积极群际接触关系中的作用。结果表明:(1)积极群际接触可以有效促进新生代农民工对群际通透性的感知;(2)新生代农民工群体受害者身份感知对积极群际接触有效性有显著的中介作用;(3)新生代农民工的城市人认同水平对积极群际接触有效性具有显著的调节作用;(4)新生代农民工群体受害者身份感知对积极群际接触有效性的中介作用不受其群体认同水平的影响。研究结论对积极群际接触的有效性和感知的群体受害者身份与群体认同的关系进行了深入地讨论。 相似文献
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To enhance the predictive validity of self-report personality measures, 2 distinct ways of increasing specificity of personality measures have been proposed in the literature—contextual specificity (i.e., providing a contextual referent) and content specificity (i.e., focusing on more specific constructs such as the Big Five facets). This study extends this line of research by examining whether there is an optimal way to configure, align, or integrate contextual and content specificity using measures of conscientiousness to predict college student success. A sample of 478 undergraduate students completed 4 measures of conscientiousness that varied in the level of content and contextual specificity. These forms of specificity were crossed to yield 4 distinct measures of conscientiousness. We then evaluated and compared the relative importance and the incremental importance of these different measures in the prediction of academic success. Superior predictive validity was found for both contextualized and facet measures of conscientiousness compared to a measure of global conscientiousness in predicting grade-point average and a broader behavioral criterion of student performance. When contextual and content specificity approaches were compared and combined, we observed the strongest predictive validity when the level of specificity is appropriately matched between predictor and criterion. 相似文献
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International Doctoral Students in Counselor Education: Coping Strategies in Supervision Training
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Hongryun Woo Yoo Jin Jang Malik S. Henfield 《Journal of multicultural counseling and development》2015,43(4):288-304
This study explores 8 international doctoral students' perceptions of coping strategies used in supervision training in counselor education programs. Using human agency as a conceptual framework, the authors found 3 categories: (a) personal and professional self‐directed strategies as personal agency, (b) support and care from mentors as proxy agency, and (c) networking among international doctoral students and/or graduates as collective agency. Implications for counselor educators are discussed. Este estudio explora las percepciones de 8 estudiantes internacionales de doctorado sobre las estrategias de afrontamiento usadas en la capacitación de supervisión en programas de educación para consejeros. Usando la agencia humana como marco conceptual, se hallaron 3 categorías: (a) estrategias autodirigidas personales y profesionales como agencia personal, (b) apoyo y cuidados recibidos de mentores como agencia delegada y (c) creación de redes de contactos entre estudiantes internacionales de doctorado y/o doctores como agencia colectiva. Se discuten las implicaciones para educadores de consejeros. 相似文献
40.
Relations between virtues and positive mental health in a Korean population: A Multiple Indicators Multiple Causes (MIMIC) model approach
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![点击此处可从《International journal of psychology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Young‐Jin Lim 《International journal of psychology》2015,50(4):272-278
A Multiple Indicators Multiple Causes (MIMIC) approach was applied to investigate the relationship between virtues and positive mental health as determined using the Character Strength Test and the Mental Health Continuum‐Short Form. The study participants were 876 college students (54% women; overall mean age [SD] 21.50 years [2.35]) recruited from introductory psychology courses at two universities in Seoul. Findings revealed that the intellectual virtues of college students predicted subjective well‐being according to all emotional, social and psychological measures. Results are discussed in the context of previous work using the Values in Action classification of virtues and character strengths. In addition, implications regarding understanding the nature and possible origins of positive mental health are outlined. 相似文献