Association of <Emphasis Type="Italic">ADAM10</Emphasis> and <Emphasis Type="Italic">CAMK2A</Emphasis> Polymorphisms with Conduct Disorder: Evidence from Family-Based Studies

Twin and family studies have shown that genetic factors play a role in the development of conduct disorder (CD). The purpose of this study was to identify genetic variants associated with CD using a family-based association study. We used 4,720 single nucleotide polymorphisms (SNPs) from the Illumina Panel and 11,120 SNPs from the Affymetrix 10K GeneChips genotyped in 155 Caucasian nuclear families from Genetic Analysis Workshop (GAW) 14, a subset from the Collaborative Study on the Genetics of Alcoholism (COGA). 20 SNPs had suggestive associations with CD (p < 10⁻³), nine of which were located in known genes, including ADAM10 (rs383902, p = 0.00036) and CAMK2A (rs2053053, p = 0.00098). Our results were verified using the International Multi-Center ADHD Genetics Project (IMAGE) dataset. In conclusion, we identified several loci associated with CD. Especially, the two genes (ADAM10 and CAMK2A) have been reported to be associated with Alzheimer’s disease, bipolar disorder and depression. These findings may serve as a resource for replication in other populations.     

You’re Better Respected When You Carry Yourself as a Man: Black Men’s Personal Accounts of the Down Low “lifestyle”

Although the notion of a down low life style, called various things at various times, has a long history in the black community, the past few years have been marked by an exponential increase in attention of this phenomenon in both the mainstream press and scholarly work. However, much of this work has focused on exploring whether men on the down low present a unique threat for HIV infection to black women. Currently, there exist very few scholarly works exploring the lives of black men who have sex with men and women that specifically address their own experiences living on the down low or how these men personally define what it means to be on the down low. In this article, we explore why black men who have sex with men and black men who have sex with men and women, including those who self-identify as gay, bisexual or as being on the down low, come to use the down low label and what it means to them to be on the down low.     

When the “Charm of Three” Fades: Mental Imagery Moderates the Impact of the Number of Ad Claims on Persuasion

Given the prevalence of imagery appeals in today’s marketplace, the current research studies the role of mental imagery in how consumers process and react to advertisements with different numbers of ad claims. Past research has proposed “three” as the magical number of ad claims that maximizes persuasion, with more than three ad claims increasing skepticism and reducing evaluation. In the current research, we replicate this so-called “charm of three” effect, but only when consumers do not engage in mental imagery; when they do, however, we find that the effect is moderated, in that more ad claims beyond three produces more favorable product evaluation. Additionally, we provide evidence that the moderating effect of mental imagery is driven by transportation and skepticism toward the ad claims, with mental imagery increasing transportation and decreasing skepticism when there are more than three ad claims. Our research contributes to a better understanding of the “charm of three” effect, its boundary conditions, and underlying mechanism.     

Self-efficacy and academic success among diverse first-generation college students: The mediating role of self-regulation

Social Psychology of Education - This study examines whether self-efficacy predicted academic success (via self-regulation) for first-generation and continuing-generation college students (Model 1)...     

Intrapersonal and Interpersonal Sources of Resilience: Mechanisms of the Relationship Between Bullying Victimization and Mental Health Among Migrant Children in China

Compared with their non-migrant peers, migrant children in China face major risks and challenges that may cause them to develop behavioral and psychological problems. Nevertheless, research has seldom addressed their victimization by bullies and its association with their mental health outcomes, much less the roles of intrapersonal and interpersonal sources of resilience in that relationship. In response, this study was designed to examine how bullying victimization both directly and indirectly influences migrant children’s mental health through intrapersonal and interpersonal sources of resilience. Data were collected from a school-based multistage random sample of 1,132 migrant children in Grades 4–9 (mean age = 11.88 years, range = 8–17 years; boys = 55.6%) attending public schools in Nanjing and private schools in Guangzhou, China. Structural equation modeling performed with Amos 25.0 revealed that both intrapersonal and interpersonal sources of resilience mediated the effect of bullying victimization on migrant children’s mental health, albeit intrapersonal sources demonstrated a slightly stronger mediation effect. The results thus suggest that social workers and educators should provide effective prevention and intervention strategies that promote intrapersonal and interpersonal sources of resilience among migrant children in China.

     

EGFR突变NSCLC二线TKIs治疗优化选择

恶性肿瘤的治疗已经进入驱动基因指导下的个体治疗时代,肺癌患者应该进行多基因检测,特别是表皮生长因子受体（EGFR）基因突变。EGFR基因突变的非小细胞肺癌（NSCLC）患者,如果一线接受了化疗,二线应该选择表皮生长因子受体一酪氨酸酶抑制剂（EGFR—TKIs）。EGFR基因突变的NSCLC患者一线EGFR—TKIs治疗失败后,二线治疗应该是个体化合理选择,包括局部放疗、化疗和继续EGFR—TKIs。目前一代和二代EGFR—TKIs药物之间未见到显著疗效差别。第三代EGFR—TKIs是目前的EGFR—TKIs耐药后的最有希望的选择,特别是针对T790M突变耐药。     

A robust vision-based method for staircase detection and localization

A robust vision-based staircase identification method is proposed, which comprises 2D staircase detection and 3D staircase localization. The 2D detector pre-screens the input image, and the 3D localization algorithm continues the task of retrieving geometry of the staircase on the reported region in the image. A novel set of principal component analysis-based Haar-like features are introduced, which extends the classical Haar-like features from local to global domain and are extremely efficient at rejecting non-object regions for the early stages of the cascade, and the Viola–Jones rapid object detection framework is improved to adapt the context of staircase detection, modifications have been made on the scanning scheme, multiple detections integrating scheme and the final detection evaluation metrics. The V-disparity concept is applied to detect the planar regions on the staircase surface and locate 3D planes quickly from disparity maps, and then, the 3D position of staircase is localized robustly. Finally, experiments show the performance of the proposed method.     

癌蛋白促凋亡现象引发的思考

肿瘤生物学中一个矛盾现象是:曾经被认为促进肿瘤生长增殖的癌蛋白,现在发现它可以引起肿瘤细胞自杀。自杀行为由癌蛋白促凋亡介导完成,MYC是其中的典型代表,癌蛋白的这种行为可能对肿瘤的发生发展具有重大意义,目前通过诱导肿瘤细胞凋亡治疗癌症是否完全合理,有待临床实践的进一步验证,今后的抗癌治疗应该辩证合理地看待肿瘤细胞凋亡。     

亲子关系对贫困儿童问题行为的影响

以247名贫困儿童为被试进行问卷调查,构建家庭社会经济地位和亲子关系对贫困儿童问题行为的多重中介模型,得到抑郁、自我控制的中介作用。结果显示,亲子关系和社会经济地位分别通过中介路径影响贫困儿童问题行为,与亲子关系有关的中介路径为91.25%,与抑郁有关的中介效应为57.60%,与自我控制有关的中介效应为57.15%. 结论：良好的亲子关系或成为贫困儿童的保护因子;应关注贫困儿童心理健康,增加有效心理疏导机制;注重培养贫困儿童的自我控制能力。     

羞怯与受欺负:社交回避与被他人容纳的多重中介效应

采用大学生羞怯量表、被他人容纳量表、大学生社交回避及苦恼量表和欺负问卷测量了369名大学生,探讨社交回避和被他人容纳在羞怯与受欺负之间的作用。结果表明:(1)羞怯、社交回避和受欺负三个变量彼此之间均呈显著正相关,这三个变量与被他人容纳均呈显著负相关;(2)羞怯不仅直接影响受欺负,也通过社交回避-被他人容纳的链式中介作用间接影响受欺负。