门脉高压症治疗观点之辩

对立统一规律是辩证法的实质,在唯物辩证法的理论体系中占有核心地位。门脉高压症的外科治疗有分流术与断流术两种不同的手术方法,这两种方法从治疗机制上看是矛盾的,用对立统一观来认识这两种手术的联系并揭示门脉高压外科治疗发展的哲学依据。     

Nicotinic cholinergic synaptic mechanisms in the ventral tegmental area contribute to nicotine addiction

Tobacco use is a major health problem that is estimated to cause 4 million deaths a year worldwide. Nicotine is the main addictive component of tobacco. It acts as an agonist to activate and desensitize nicotinic acetylcholine receptors (nAChRs). A component of nicotine's addictive power is attributable to actions on the mesolimbic dopaminergic system, which serves a fundamental role in the acquisition of behaviors that are inappropriately reinforced by addictive drugs. Here we show that nicotine, in the same concentration and time ranges as obtained from tobacco, has three main actions that regulate the activity of midbrain dopamine (DA) neurons. Nicotine first activates and then desensitizes nAChRs on the DA neurons. This process directly excites the DA neurons for a short period of time before the nAChRs desensitize. Nicotine also enhances glutamatergic excitation and decreases GABAergic inhibition onto DA neurons. These events increase the probability for synaptic plasticity, such as long-term potentiation. The short-lived direct excitation of the DA neurons coupled with the enhanced glutamatergic afferent activity provides the presynaptic and postsynaptic coincidence necessary to initiate synaptic potentiation. In total, these synaptic events lead to a relatively long-lasting heightened activity of midbrain DA neurons. Consistent with other summarized studies, this work indicates that the synaptic changes normally associated with learning and memory can be influenced and commandeered during the nicotine addiction process.     

科学划界与中医

科学划界就是在科学与非科学之间作出区分,依据科学划界的逻辑主义的绝对标准、历史主义的相对标准以及重建划界的多元标准,中医不晃科学,但中医也不是伪科学,而是一门实用的技艺,因此中医科学化、现代化及中西医结合的提法有待于进一步商榷。我们反对把中医伪科学化,中医的出路只有一条,那就是融入现代医学的发展之中,为医学的发展而奉出自己的经验和思路。     

Selective Abolition of the NMDA Component of Long-Term Potentiation in Mice Lacking mGluR5

The mechanisms underlying the differential expression of long-term potentiation (LTP) by AMPA and NMDA receptors, are unknown, but could involve G-protein-linked metabotropic glutamate receptors. To investigate this hypothesis we created mutant mice that expressed no metabotropic glutamate receptor 5 (mGluR5), but showed normal development. In an earlier study of these mice we analyzed field-excitatory postsynaptic potential (fEPSPs) in CA1 region of the hippocampus and found a small decrease; possibly arising from changes in the NMDAR-mediated component of synaptic transmission. In the present study we used whole-cell patch clamp recordings of evoked excitatory postsynaptic currents (EPSCs) in CA1 pyramidal neurons to identify the AMPAR- and NMDAR-mediated components of LTP. Recordings from control mice following tetanus, or agonist application (IS, 3R-1-amino-cyclopentane 1,3-dicarboxylic acid) (ACPD), revealed equal enhancement of the AMPA and NMDA receptor-mediated components. In contrast, CA1 neurons from mGluR5-deficient mice showed a complete loss of the NMDA-receptor-mediated component of LTP (LTP_NMDA), but normal LTP of the AMPA-receptor-mediated component (LTP_AMPA). This selective loss of LTP_NMDA was seen in three different genotypic backgrounds and was apparent at all holding potentials (−70 mV to +20 mV). Furthermore, the LTP_NMDA deficit in mGluR5 mutant mice could be rescued by stimulating protein kinase C (PKC) with 4β-phorbol-12,13-dibutyrate (PDBu). These results suggest that PKC may couple the postsynaptic mGluR5 to the NMDA-receptor potentiation during LTP, and that this signaling mechanism is distinct from LTP_AMPA. Differential enhancement of AMPAR and NMDA receptors by mGluR5 also supports a postsynaptic locus for LTP.     

Emotional labour strategies and job burnout: A meta-analysis of Chinese employees

Emotional labour strategies have a significant impact on job burnout. However, current research results are controversial and unclear. A meta-analysis was conducted to explore the relationship between emotional labour strategies (surface acting and deep acting) and job burnout. A total of 84 empirical studies that included 28,242 participants were selected. The meta-analysis of the relationships between job burnout and surface acting and deep acting included 84 and 75 independent samples respectively. The results show that surface acting had a positive association (r = 0.25) with job burnout, whereas deep acting (r = −0.27) had a negative association with job burnout. Occupational types and measures of emotional labour strategies moderated the relationship between emotional labour strategies and job burnout, but this relationship was not moderated by measures of job burnout.     

Individual differences in harm-related moral values are associated with functional integration of large-scale brain networks of emotional regulation

Emotions affects moral judgements, and controlled cognitive processes regulate those emotional responses during moral decision making. However, the neurobiological basis of this interaction is unclear. We used a graph theory measurement called participation coefficient (‘PC’) to quantify the resting-state functional connectivity within and between four meta-analytic groupings (MAGs) associated with emotion generation and regulation, to test whether that measurement predicts individual differences in moral foundations-based values. We found that the PC of one of the MAGs (MAG2) was positively correlated with one of the five recognized moral foundations–the one based on harm avoidance. We also found that increased inter-module connectivity between the ventromedial prefrontal cortex, dorsolateral prefrontal cortex and middle temporal gyrus with other nodes in the four MAGs was likewise associated with higher endorsement of the Harm foundation. These results suggest that individuals' sensitivity to harm is associated with functional integration of large-scale brain networks of emotional regulation. These findings add to our knowledge of how individual variations in our moral values could be reflected by intrinsic brain network organization and deepen our understanding of the relationship between emotion and cognition during evaluations of moral values.     

时间透视的自我整合:I.心理结构方式的投射测验

用画圆测验和完成句子测验,配合时间标定作业,对２０１名大学生被试的时间透视特点作了探讨,结果发现,在时间透视的广度、方向及关联性等方面,高自我认同组被试有着更大的现有广度,更积极而远景开放的未来取向,以及更强的时间整合;低自我认同组则是过去广度更大,其时间分裂及未来中断的现象理易发生。这些结果初步揭示了建立在时间体验与自我概念的整合基础上的时间透视的心理结构方式。     

时间透视的自我整合:Ⅱ.心理功能机制的实验研究

以２４个人格形容词为材料,对１１１名大学生被试进行了“过去的我”、“现在的我”和“将来的我”三择一式的迫选反应实验,再配合时间标定作业。结果不仅验证了前文的研究结论,即不同同一性状态的被试在时间透视的广度、方向及关联性等心理结构特征上存在差异,而已表明了整合自我信息的不同的功能机制。不过,这种差异主要体现在积极词上,在消极词上差异不显著。     

社会行为的效价信息对注意捕获的影响：基于帮助和阻碍行为的探讨

采用学习-测验两任务范式, 通过3项实验探讨了社会行为的效价信息对注意捕获的影响。在学习阶段, 被试观看具有积极效价的帮助行为(某智能体帮助另一智能体爬山)和消极效价的阻碍行为(某智能体阻碍另一智能体爬山), 以及与各自运动特性匹配的无社会交互行为, 其目的为建立不同智能体颜色与社会行为效价信息的联结关系。在测验阶段, 则分别检验社会行为中的施动方(帮助者和阻碍者)颜色和受动方(被帮助者和被阻碍者)颜色的注意捕获效应。结果发现, 消极社会行为中施动方颜色和受动方颜色均更容易捕获注意, 而积极社会行为效价信息并没有改变联结特征值的注意捕获效应; 且相比于受动方, 与消极社会行为效价建立联结的施动方颜色的注意捕获效应更强。该结果提示, 存在消极社会行为效价驱动的注意捕获, 且消极的效价信息与卷入社会行为所有个体的特征建立联结, 但该联结中施动方物理特征具有更高的注意优先性。这一发现暗示, 声誉信息与对社会交互行为的整体表征可能综合作用于对社会交互事件的注意选择。     

Attachment style predicts cooperation in intuitive but not deliberative response in one-shot public goods game

Cooperation is an important prosocial behaviour that is of great significance to individuals and society. The social heuristics hypothesis (SHH) systematically explains how cooperation is interactively affected by intuitive and deliberative processes. On the one hand, the intuitive process can be either cooperative or selfish, which is determined by previous experience. On the other hand, the deliberative process could support either a cooperative decision or a selfish decision, depending on which strategy could maximise the current payoff. This research aims to investigate the mechanism of cooperation. Attachment style was selected as a proxy for previous experience to examine whether and how previous life experience shapes intuitive response. Time constraint (Studies 1 and 2) and cognitive load (Study 3) were manipulated to dissociate the intuitive and deliberative processes. In addition, cooperation was assessed by adopting one-shot public goods games. Results showed that attachment avoidance (Studies 1, 2, and 3) and attachment anxiety (Study 3) significantly predicted cooperation in the intuition condition, whereas these associations were insignificant in the deliberation condition (Studies 1, 2, and 3). These findings provide further support for the SHH and shed new light on the mechanism of cooperation.