科学划界与中医

科学划界就是在科学与非科学之间作出区分,依据科学划界的逻辑主义的绝对标准、历史主义的相对标准以及重建划界的多元标准,中医不晃科学,但中医也不是伪科学,而是一门实用的技艺,因此中医科学化、现代化及中西医结合的提法有待于进一步商榷。我们反对把中医伪科学化,中医的出路只有一条,那就是融入现代医学的发展之中,为医学的发展而奉出自己的经验和思路。     

Selective Abolition of the NMDA Component of Long-Term Potentiation in Mice Lacking mGluR5

The mechanisms underlying the differential expression of long-term potentiation (LTP) by AMPA and NMDA receptors, are unknown, but could involve G-protein-linked metabotropic glutamate receptors. To investigate this hypothesis we created mutant mice that expressed no metabotropic glutamate receptor 5 (mGluR5), but showed normal development. In an earlier study of these mice we analyzed field-excitatory postsynaptic potential (fEPSPs) in CA1 region of the hippocampus and found a small decrease; possibly arising from changes in the NMDAR-mediated component of synaptic transmission. In the present study we used whole-cell patch clamp recordings of evoked excitatory postsynaptic currents (EPSCs) in CA1 pyramidal neurons to identify the AMPAR- and NMDAR-mediated components of LTP. Recordings from control mice following tetanus, or agonist application (IS, 3R-1-amino-cyclopentane 1,3-dicarboxylic acid) (ACPD), revealed equal enhancement of the AMPA and NMDA receptor-mediated components. In contrast, CA1 neurons from mGluR5-deficient mice showed a complete loss of the NMDA-receptor-mediated component of LTP (LTP_NMDA), but normal LTP of the AMPA-receptor-mediated component (LTP_AMPA). This selective loss of LTP_NMDA was seen in three different genotypic backgrounds and was apparent at all holding potentials (−70 mV to +20 mV). Furthermore, the LTP_NMDA deficit in mGluR5 mutant mice could be rescued by stimulating protein kinase C (PKC) with 4β-phorbol-12,13-dibutyrate (PDBu). These results suggest that PKC may couple the postsynaptic mGluR5 to the NMDA-receptor potentiation during LTP, and that this signaling mechanism is distinct from LTP_AMPA. Differential enhancement of AMPAR and NMDA receptors by mGluR5 also supports a postsynaptic locus for LTP.     

Individual differences in harm-related moral values are associated with functional integration of large-scale brain networks of emotional regulation

Emotions affects moral judgements, and controlled cognitive processes regulate those emotional responses during moral decision making. However, the neurobiological basis of this interaction is unclear. We used a graph theory measurement called participation coefficient (‘PC’) to quantify the resting-state functional connectivity within and between four meta-analytic groupings (MAGs) associated with emotion generation and regulation, to test whether that measurement predicts individual differences in moral foundations-based values. We found that the PC of one of the MAGs (MAG2) was positively correlated with one of the five recognized moral foundations–the one based on harm avoidance. We also found that increased inter-module connectivity between the ventromedial prefrontal cortex, dorsolateral prefrontal cortex and middle temporal gyrus with other nodes in the four MAGs was likewise associated with higher endorsement of the Harm foundation. These results suggest that individuals' sensitivity to harm is associated with functional integration of large-scale brain networks of emotional regulation. These findings add to our knowledge of how individual variations in our moral values could be reflected by intrinsic brain network organization and deepen our understanding of the relationship between emotion and cognition during evaluations of moral values.     

New Fathers’ Perceptions of Dyadic Adjustment: The Roles of Maternal Gatekeeping and Coparenting Closeness

Although the association between maternal gatekeeping and relationship functioning has been explored by a few studies, none of these have focused on fathers’ perceptions of these constructs. Given that today's new fathers are challenged by elevated expectations for active parenting and coparenting even as most new mothers remain primary caregivers of infant children, this is a critical omission. This study examined the associations between new fathers’ perceptions of maternal gatekeeping and change in dyadic adjustment as mediated through coparenting closeness. Maternal gatekeeping was reported by 182 fathers at 3 months postpartum, coparenting closeness was reported at 3 and 6 months postpartum, and dyadic adjustment was reported during the third trimester of pregnancy and at 9 months postpartum. Fathers’ perceptions of relative change in coparenting closeness from 3 to 6 months mediated associations between fathers’ perceptions of maternal gatekeeping at 3 months and relative change in dyadic adjustment from the third trimester to 9 months postpartum. In particular, findings indicate that greater perceived maternal gate opening was associated with higher levels of dyadic adjustment through higher levels of coparenting closeness, whereas greater perceived maternal gate closing was associated with lower levels of dyadic adjustment through lower levels of coparenting closeness. This study highlights the importance of studying fathers in the context of the family system and the role of the coparenting relationship at the transition to parenthood in couple relationship functioning.     

Attachment style predicts cooperation in intuitive but not deliberative response in one-shot public goods game

Cooperation is an important prosocial behaviour that is of great significance to individuals and society. The social heuristics hypothesis (SHH) systematically explains how cooperation is interactively affected by intuitive and deliberative processes. On the one hand, the intuitive process can be either cooperative or selfish, which is determined by previous experience. On the other hand, the deliberative process could support either a cooperative decision or a selfish decision, depending on which strategy could maximise the current payoff. This research aims to investigate the mechanism of cooperation. Attachment style was selected as a proxy for previous experience to examine whether and how previous life experience shapes intuitive response. Time constraint (Studies 1 and 2) and cognitive load (Study 3) were manipulated to dissociate the intuitive and deliberative processes. In addition, cooperation was assessed by adopting one-shot public goods games. Results showed that attachment avoidance (Studies 1, 2, and 3) and attachment anxiety (Study 3) significantly predicted cooperation in the intuition condition, whereas these associations were insignificant in the deliberation condition (Studies 1, 2, and 3). These findings provide further support for the SHH and shed new light on the mechanism of cooperation.     

社会行为的效价信息对注意捕获的影响：基于帮助和阻碍行为的探讨

采用学习-测验两任务范式, 通过3项实验探讨了社会行为的效价信息对注意捕获的影响。在学习阶段, 被试观看具有积极效价的帮助行为(某智能体帮助另一智能体爬山)和消极效价的阻碍行为(某智能体阻碍另一智能体爬山), 以及与各自运动特性匹配的无社会交互行为, 其目的为建立不同智能体颜色与社会行为效价信息的联结关系。在测验阶段, 则分别检验社会行为中的施动方(帮助者和阻碍者)颜色和受动方(被帮助者和被阻碍者)颜色的注意捕获效应。结果发现, 消极社会行为中施动方颜色和受动方颜色均更容易捕获注意, 而积极社会行为效价信息并没有改变联结特征值的注意捕获效应; 且相比于受动方, 与消极社会行为效价建立联结的施动方颜色的注意捕获效应更强。该结果提示, 存在消极社会行为效价驱动的注意捕获, 且消极的效价信息与卷入社会行为所有个体的特征建立联结, 但该联结中施动方物理特征具有更高的注意优先性。这一发现暗示, 声誉信息与对社会交互行为的整体表征可能综合作用于对社会交互事件的注意选择。     

管理心理学的现状与发展趋势

本文在综合分析了国内外管理心理学发展概况的基础上认为,在适应经济全球化和企业不断变革的情况下,组织变革、领导行为、激励机制和组织文化是管理心理学的研究新热点,管理心理学的发展趋势是重视组织层面的变革研究,强调对人力资源的系统开发,研究领域不断拓展,更加关注国家目标.并提出了管理心理学研究的近期目标和中长期发展目标的建议.     

增殖和凋亡的单独与联合检测对垂体瘤侵袭性诊断的价值

垂体瘤是颅内常见的良性肿瘸,但却存在着较高的复发率。Jefferson于1940年提出侵袭性垂体腺瘸的概念,认为这部分垂体腺瘤的生物学行为介于良性垂体瘤和垂体癌之间。随后人们从分子生物学、病理学等多个角度对侵袭性腺瘸的发病机制进行了探讨,以期寻找到特异性的侵袭性指标。众所周知,细胞增殖能力的增强和凋亡的抑制是导致肿瘤恶性生物学行为的重要机制。但对垂体瘤的研究却发现有为数不少的侵袭性垂体腺瘸并不呈现高细胞增殖状态。而凋亡的研究则更是出现了不同甚至相反的结果,那到底是什么原因导致了侵袭性的形成呢？本文从细胞增殖和凋亡各自的临床意义以及其联合检测的角度探讨侵袭性的确切机制。     

高等医学院校综合性通识课程内容的构建

21世纪是通识教育与专业教育逐步走向综合的世纪,而综合性通识课程内容的构建则是通识课程改革的关键.为了有助于我国医学院校构建综合性通识课程,通过对不同国家和地区综合性通识课程内容的组织、设计和实施的分析,探讨了高等医学院校综合性通识课程内容的构建.     

系统生物学——中西医结合的平台

通过比较系统生物学与中医理论在整体观、系统观、预测性和预防性医疗以及个体化治疗等方面的相似之处,并分析中医和西医各自的优点和不足,提出中医和现代医学在系统生物学的基础上进行整合的必然性和可能性,系统生物学是中西医结合的平台.