Cognitive impairment in the early phase of multiple sclerosis and its relationship with mood, demographic and clinical variables

Our aim was to study cognitive performance in the early phase of MS. In addition, we studied whether depression, demographic and clinical variables differentiate cognitively impaired patients from non-impaired patients. A group of 52 MS-RR patients with mild level of neurological disability and 51 healthy controls were administered a comprehensive neuropsychological battery. The MS group performed significantly worse on several measures of attention and processing speed and visuoperceptive/visuoconstructive tasks. Verbal memory is characterized by working memory deficits, whereas the visual memory impairment is attributable to deficits in acquisition and consolidation/recuperation. Results shows that cognitive impairment is evident even in MS patients in the early course of their disease. Depression scores were higher in cognitively impaired patients as compared with unimpaired patients. The effect of educational level suggests that higher education delays the onset of cognitive decline.     

Simplicity and generalization: Short-cutting abstraction in children's object categorizations

Development in any domain is often characterized by increasingly abstract representations. Recent evidence in the domain of shape recognition provides one example; between 18 and 24 months children appear to build increasingly abstract representations of object shape [Smith, L. B. (2003). Learning to recognize objects. Psychological Science, 14, 244-250]. Abstraction is in part simplification because it requires the removal of irrelevant information. At the same time, part of generalization is ignoring irrelevant differences. The resulting prediction is this: simplification may enable generalization. Four experiments asked whether simple training instances could shortcut the process of abstraction and directly promote appropriate generalization. Toddlers were taught novel object categories with either simple or complex training exemplars. We found that children who learned with simple objects were able to generalize according to shape similarity, typically relevant for early object categories, better than those who learned with complex objects. Abstraction is the product of learning; using simplified - already abstracted instances - can short-cut that learning, leading to robust generalization.     

Evaluation of Halpern's "structural component" for improving critical thinking

Halpern (1998) proposed a four-component model for promoting the transfer of critical thinking. One of them, the "structural component," focuses on how to organize teaching so that critical thinking skills can be generalized. Here, we assess the efficiency of that type of organization. Thus, one group of university students received instruction following the suggestions specified in that component and their performance was compared with that of other university students who received instruction in the same skills but using a different procedure, and with that of a control group. In comparison with the control group, the performance of both instructed groups was better after training. However, no significant differences were observed between either instruction group; both forms of instruction afforded very similar results.     

教师上级信任、知识分享与工作绩效的关系

知识分享和组织信任能够有效提高绩效,已在企业组织中得到证实,但在学校组织中是否成立及作用路径如何鲜有实证研究探讨。本研究以天津市10所学校的168名教师为研究对象,通过问卷调查探讨教师对直接上级的信任、知识分享及教师工作绩效之间的关系。路径分析结果显示：教师上级信任和知识分享的不同维度对教师工作绩效的影响存在差异;教师知识分享的质量在教师上级信任的依赖维度与工作绩效的关系中起部分中介作用。     

The Manifestation Range of Innately Good Knowledge and Ability,and the Danger of Separation: On Zhuzi’s Question about Understanding Words

Zhuzi (Zhu Xi), Zhang Nanxuan and Lü Donglai continued a discussion begun by Hu Wufeng and his disciples on the subject of “knowing the form of benevolence,” and “seeking for a true mind in an absent one.” One result of their discussion was to make people realize that innately good knowledge and ability are not only manifested in loving one’s parents and respecting one’s elders, but also in the simple acts of drinking when thirsty and eating when hungry. This generated the idea of “manifestation range of innately good knowledge and ability.” However, another conclusion of this discussion claimed that if the desire to drink and eat or the king of Qi’s grudging an ox are included in this range, there would be a danger of viewing innately good knowledge and ability merely as inborn human nature or instinct. This discussion reveals an unsteady relationship between innately good knowledge and ability and the feeling of commiseration, which are sometimes united and sometimes separate.     

Cognitive diagnosis models for multiple strategies

Cognitive diagnosis models (CDMs) have been used as psychometric tools in educational assessments to estimate students’ proficiency profiles. However, most CDMs assume that all students adopt the same strategy when approaching problems in an assessment, which may not be the case in practice. This study develops a generalized multiple-strategy CDM for dichotomous response data. The proposed model provides a unified framework to accommodate various condensation rules (e.g., conjunctive, disjunctive, and additive) and different strategy selection approaches (i.e., probability-matching, over-matching, and maximizing). Model parameters are estimated using the marginal maximum likelihood estimation via expectation-maximization algorithm. Simulation studies showed that the parameters of the proposed model can be adequately recovered and that the proposed model was relatively robust to some types of model misspecifications. A set of real data was analysed as well to illustrate the use of the proposed model in practice.     

On the neurobiological redefinition of psychiatric symptoms: elimination,reduction, or what?

Synthese - Because biologization of psychiatric constructs does not involve derivation of laws, or reduce the number of entities involved, the traditional term of ‘reduction’ should be...     

Right- and left-wing prejudice toward dissimilar groups in cultural and economic domains

According to recent studies, people on both the political right and left show prejudice toward groups whose beliefs are in conflict with their own. This prediction applies to both cultural and economic dimensions of political beliefs. In three studies (N = 499) we demonstrate that people on both the cultural and economic right and left show negative attitudes toward groups on the other side of the given spectrum and that underlying this effect is the perception of value violation. In two out of three studies, we manipulated the extremity of target worldviews to further explore the causal chain between political beliefs, the perception of value violation, and prejudice. Our results showed a high degree of symmetry between the political left and right in their attitudes toward groups with dissimilar beliefs. However, although people on both sides of the political spectrum show prejudice toward each other, people on the cultural and economic right seem to be more sensitive to value violations than people on the left.     

药物不良反应补偿体系国际比较研究

药品在治疗疾病过程中有着不可或缺的作用,但药品在使用过程中也往往容易发生药物不良反应,并造成患者很重的经济负担,很多国家都针对药品不良反应建立救济保险制度。从基金筹资、补偿制度、管理等角度对国际上几个国家的药物不良反应补偿体系进行分析,以期我们在建立自己相应的药物不良反应补偿体系时有所借鉴。     

基于默会知识的循证医学耗散结构观

阐述了循证医学的理论核心——最佳证据实质是一种默会知识,并指出应当把最佳证据视为一种默会知识,循证医学就会形成一种耗散结构。提出利用耗散结构理论显化默会知识寻找最佳证据的动力学规律和方法论。