加压素对记忆巩固过程作用的研究 Ⅲ.GABA能药物对加压素易化大白鼠被动回避反应的影响

本文以平台被动回避反应为行为模式,采用侧脑室微量注射AVP和GABA能受体激动剂蝇蕈醇(Muscimol)、受体拮抗剂印防己毒素(Picrotoxin),进一步研究了AVP易化记忆巩固效应及与中枢GABA能系统的关系。主要实验结果如下: 1.AVP对被动回避行为模式的学习训练过程无促进作用,但促进了这种行为的记忆巩固过程,注射AVP的动物记忆保持能力显著高于对照组动物,有效剂量为30ng/大鼠。 2.侧脑室注射100ng/大鼠蝇蕈醇后,AVP仍非常显著地保持其行为效应,但注射100ng/大鼠印防己毒素后,AVP的效应已见下降,剂量增至300ng/大鼠后,AVP的效应已被完全消除。 实验结果再次提示,加压素具有促进记忆巩固过程的中枢性效应,脑内GABA能神经元的活动可能参与了这种效应。     

Adult age differences in the ability to cope with situations of high arousal in a precision sport

Three field experiments are reported in which skilled miniature golf players varying in age were studied in three types of activities: training, minor competitions, and large competitions. Performance (i.e., number of shots) and arousal (heart rate and subjective ratings of anxiety) measures were registered in all types of activities. The major finding was that the level of performance of older adult players deteriorated in the large competitions, whereas groups of younger adult players, junior players, and youth players performed at the same level in all three events, although all of the groups exhibited a similar increase in arousal from training and minor competitions to large competitions. We suggest that older players may have a deficit in the ability to compensate for the negative effects of nonoptimal levels of arousal because of impairments in a variety of cognitive abilities critical to successful performance.     

Thermographic studies with fluid crystals in peripheral nerve damage

Common peripheral neurogenic lesion in various locations and of different origins were examined thermographically and the results were compared with those obtained by clinical and electromyographic methods. Lesions in the regions of the N. ulnaris and N. medianus can, except in the case of carpal tunnel syndrome, be identified without difficulty by thermography. The results obtained in the case of paresis of the radialis are non-specific, and thermographic examination of radicular lesions are also sometimes ambiguous. Damage in the plexus-brachialis and root region yield impressive results which, however, are not particularly useful.     

Readiness for professional psychotherapy

Statistics dealing with transfers to, and attendance at psychotherapy sessions and with patients' reasons for prematurely terminating such treatment are first analyzed. Causes of unwillingness to accept such treatment despite suffering are then presented. The author concludes that standards of everyday psychology require improvement, that psychotherapy should be accepted as an integral part of basic medical care, and that measures should be taken to make the symptoms indicating the need for such treatment more widely known and to give more realistic expectations of what it can achieve.     

Prostaglandins and endogenous psychoses

The authors refer to the biochemical investigation of the occurrence and metabolism of essential fatty acids in the CNS and to significant differences in results between those obtained in animal experiments and those involving human beings, taking into account hypotheses that have not yet met with general acceptance. Discussed is the possible connection between eicosanic acid and schizophrenia, notably Horrobin's hypothesis of PGE1 deficiency in schizophrenic patients. The probability of a pathogenetic connection between changes in the metabolism of fatty acids and the occurrence of endogenous psychoses is assumed.     

A psychometric evaluation of a residential treatment facility: an illustration of an interpretable research design without a control group

This paper reports on the interim results of an evaluation study which followed a group of disordered-delinquent adolescents discharged from a long-term residential treatment program. Findings from the first cohort of adolescents tested at admission and discharge with the Tennessee Self-Concept Scale (TSCS) indicate statistically significant improvement in all the areas of self-concept, significant decreases in all areas of psychopathology, and no systematic response set at either testing. The research design is unique in that, without a control group, competing interpretations of treatment effectiveness have been ruled out. Using design features, clinical observation, and common sense, four competing explanations of the favorable results have been eliminated. Both the instrument and research design are of interest to those undertaking evaluation research in underfunded settings where control groups are difficult to obtain due to financial or logistical problems.     

视场大小对色光和白光的临界融合频率的影响

本实验采用闪烁光度法。刺激光为红光(670nm)、绿光(560nm)、蓝光(450nm)和白光。亮度级为200尼特、20尼特和2尼特。视场约为2°、1°、0.5°和0.25°。受试者3人,均属色觉正常者,具有一定实验经验。结果表明:在同一亮度级上,大小相同的视场内,绿光的CFF都明显地高于明度相同的红光和蓝光的CFF;在同一亮度级上,色光和白光的CFF都随着视场面积的增加而增加。并且CFF-Log面积接近线性关系;在不同亮度级上,CFF-Log面积的直线料率并不相同。2尼特时的直线斜率小于20尼特、200尼特时的直线斜率。