Characterization of a dose-response curve for nicotine-induced conditioned taste aversion in rats: relationship to elevation of plasma beta-endorphin concentration

In the first experiment a conditioned taste aversion paradigm was used to characterize a dose-response curve for the aversive properties of nicotine in male Sprague-Dawley rats. Doses of nicotine ranging from 0.01 to 0.46 mg/kg, 2.0 ml of 0.47 M lithium chloride, or saline were injected, ip, 10 min after exposure to a novel saccharin solution. Amount of saccharin consumed in a two-bottle test was assessed 72 h later. Nicotine doses of 0.046 mg/kg and above produced a significant degree of conditioned taste aversion. In a second experiment, four groups of 10 rats each were injected with saline, 0.022 mg/kg nicotine, 0.46 mg/kg nicotine, or 2.0 ml 0.47 of M LiCl. Doses of 0.46 mg/kg nicotine and 0.47 M LiCl elevated plasma beta-endorphin concentrations significantly above saline control values. The 0.022 mg/kg dose, the highest dose that did not produce conditioned taste aversion in Experiment 1, did not significantly increase plasma beta-endorphin concentrations. This finding suggests that doses of nicotine that produce conditioned taste aversion also promote the release of pituitary stress hormones. Taken together these data suggest that some of the pharmacological and behavioral effects attributed to nicotine, including the release of endogenous neuromodulators, may be dose-dependent concomitants of the aversive effects of nicotine in nicotine-naive animals.     

Parental Emotional Response to Children’s Traumas

To better understand how parents react to their child’s trauma exposure and evaluate whether different reactions are related to different types of traumas, 120 parents (79.2% mothers, 18.3% fathers, 2.5% other caregivers) were asked about their emotional reactions related to their child’s self-reported worst trauma. Emotional reactions were assessed with the Parental Emotional Reactions Questionnaire (PERQ). Parents reported high levels of distress and guilt. Furthermore, there was a significant relationship between type of trauma and parents’ overall emotional reactions. Parental distress was equally endorsed among the different trauma groups. Parents of children who experienced intrafamilial violence and extrafamilial sexual abuse reported the highest levels of guilt, and child exposure to intrafamilial violence was associated with higher levels of parental shame.