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There has been limited examination of the effect of brain pathology on subsequent function. The current study examined the relationships between regional variation in grey matter volume, age and cognitive impairment using a semi-automated image analysis tool. This study included 69 individuals with mild-to-severe TBI, 41 of whom also completed neuropsychological tests of attention, working memory, processing speed, memory and executive functions. A widespread reduction in grey matter volume was associated with increasing age. Regional volumes that were affected also related to the severity of injury, whereby the most severe TBI participants displayed the most significant pathology. Poorer retention of newly learned material was associated with reduced cortical volume in frontal, parietal, and occipital brain regions. In addition, poorer working memory and executive control performance was found for individuals with lower cortical volume in temporal, parietal, and occipital regions. These findings are largely in line with previous literature, which suggests that frontal, temporal, and parietal regions are integral for the encoding of memories into long-term storage, memory retrieval, and working memory. The present study suggests that automated image analysis methods may be used to explore the relationships between regional variation in grey matter volume and cognitive function following TBI.  相似文献   
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Emergence, the occurrence of novel, unpredictable human behavior, is an inherent aspect of human experience on both the individual and collective levels. In this article, we considered the ubiquitous nature emergent events, indicated some of the ways such events manifest themselves, analyzed the personal and inter-personal processes that give rise to them, and suggested some of their implications for psychology and the other social science. Given the inescapable presence of emergence in human conduct, a redefinition of the goals and scope of social science may be desirable.  相似文献   
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This review outlines ethical, legal, and practical issues related to conducting functional imaging research with Alzheimer's disease (AD) patients. Imaging techniques, with an emphasis on functional MRI and positron emission tomography, are compared and contrasted with respect to the manner in which they can be applied to issues of clinical relevance to AD. Methodological difficulties are raised to assist with critical evaluation of current imaging results. Various potential clinical applications of functional imaging are briefly reviewed and discussed with respect to associated ethical conflicts.  相似文献   
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Abstract

This study examined (a) the predictions of multidimensional anxiety theory, (b) the effect of interpreting anxiety responses as having a debilitative or facilitative effect on performance, and (c) the influence of a repressive coping style on the relationship of anxiety to performance in recreational and semi-professional bowlers (N = 158). Regression analyses indicated cognitive intensity had an inverted-U relationship to performance that explained 4.1% of the variance (p < .05). The somatic direction subscale had a positive linear relationship to performance that explained 3.0% of the variance (p < .05). Removing bowlers with a repressive coping style resulted in a stronger and different anxiety-performance relationship. Cognitive intensity kept an inverted-U relationship, but increased the performance variance explained to 12.6%. Somatic intensity became significant, but with a negative linear relationship that explained 6.1% of performance variance. The findings did not support multi-dimensional anxiety theory and offered only limited support for inclusion of directional interpretation scales.  相似文献   
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Defining dysphoria as subclinical depression, we explored the extent to which maternal dysphoria influences the quality of relationships within the family and evaluated whether the effect of dysphoria on family relationships is selective or general and whether dysphoric effects on maternal behavior are similar or different when ratings of maternal behaviors are made by mothers versus observers. We expected that dysphoria would have general rather than selective effects on family relations rated by mothers and observers. In a sample of 40 American families at risk of child abuse or neglect, we found that maternal dysphoria did have significantly negative effects on mother-to-child and mother-to-parenting-partner relations, suggesting that maternal dysphoria has general rather than selective effects.  相似文献   
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