Are research subjects adequately protected? A review and discussion of studies conducted by the Advisory Committee on Human Radiation Experiments

In light of information uncovered about human radiation experiments conducted during the Cold War, an important charge for the Advisory Committee on Human Radiation Experiments was to assess the current state of protections for human research subjects. This assessment was designed to enhance the Committee's ability to make informed recommendations for the improvement of future policies and practices for the protection of research subjects. The Committee's examination of current protections revealed great improvement over those from the past, yet some problems remain. Although the data collected by the Committee highlight specific areas in need of attention, the Committee's work should be viewed in part as the beginning of a series of ongoing assessments of the adequacy and effectiveness of the protections afforded to human subjects.     

Prepulse effects on magnitude estimation of startle-eliciting stimuli and startle responses

The present studies investigated the relationship between prepulse effects on the modification of the brainstem startle reflex and magnitude estimates of startle-eliciting stimuli. In Experiment 1, startle eyeblink responses were elicited in 24 students, half of whom were instructed to estimate the loudness of the startle stimulus (actual intensities of 80, 90, and 100 dB) and half of whom were instructed to estimate the magnitude of their eyeblink. When weak acoustic prepulses preceded the startle-eliciting stimulus, eyeblink amplitude was inhibited, and estimates of response magnitude decreased, but estimates of startle stimulus magnitude decreased only when 100-dB startle stimuli were presented. In Experiment 2, the same startle stimuli were preceded on some trials by a vibrotactile prepulse to the hand. In conditions in which startle amplitude was inhibited, startle stimulus magnitude estimates were not affected. This suggests that the effect of acoustic prepulses on 100-dB startle stimuli in Experiment 1 may have been due to loudness assimilation, an effect independent of the prepulse inhibition of startle responding.     

Behavior of neonates exposed in utero to methadone as assessed on the Brazelton scale

Twenty-nine infants exposed in utero to methadone and 37 comparison infants were examined on the Neonatal Behavioral Assessment Scale at early and late neonatal ages. All infants were full-term at birth, over 2500 g, and not yet circumcised at the early assessment. None of the methadone-exposed infants were breast-fed or were being treated pharmacologically for withdrawal. During the first week of life, methadone-exposed neonates differed from comparison ones in motoric behavior. Relative to comparison-group infants, they were jerkier and more tremulous, tense, active, and better able to put hand in mouth. By the end of the first month these differences diminished, although there was still a tendency for the methadone-exposed infants to have elevated body tonus. Neither perinatal complications, birth weight, nor sex of infant could explain the early neonatal differences between the methadone and comparison groups. Past the early stage of acute withdrawal, neonates exposed prenatally to methadone behave not unlike their nonexposed peers.     

VideoNoter: A productivity tool for video data analysis

The software described in this paper, VideoNoter, addresses the need for tools that support annotation and retrieval of video data and organize the presentation of multiple analyses of the same data. Video is widely perceived as an important medium for psychological research, because video recording makes the fleeting particulars of human interaction available as data for detailed analysis, while retaining much of the context of the event. Though the benefits of using video data are high, the process can be prohibitively time-consuming. We have developed a prototype computer-based video analysis tool that can enhance the productivity of the video analysis process. In this paper, we report on the design and implementation of VideoNoter, and we discuss how it facilitates video data analysis.     

The problem of pointlessness — a challenge for counselling

A sense of pointlessness is a deep problem which underlies many more familiar problems. Its origins lie in deeply-rooted feelings of personal insignificance which can only be resolved by a genuine experience of relationship. The possibilities of establishing such a relationship in a counselling setting are examined with reference to condensed case-histories and relevant psycho-dynamic theory.     

Philosophy of medicine in 2021

Theoretical Medicine and Bioethics -     

Differential age effects for case and hue mixing in visual word recognition

The authors compare older adults' lexical-decision data with younger adults' data reported in P. Allen, A. F. Smith, et al. (2002). On the basis of their work, it was proposed that consistent-case wordswould be processed by the faster holistic (magnodominated) stream, but that mixed-case words would be processed by the slower analytic (interblob-dominated or blob-dominated) steams. Hue mixing was predicted to have no effect on consistent-case performance, but mixed-hue/mixed-case words were predicted to be recognized faster than monochrome/mixed-case words. Younger adults showed the predicted results, but older adults did not. These results suggest that holistic central processes are maintained, but that older adults exhibited an analytic decrement     

Prefrontal brain activity predicts temporally extended decision-making behavior

Although functional neuroimaging studies of human decision-making processes are increasingly common, most of the research in this area has relied on passive tasks that generate little individual variability. Relatively little attention has been paid to the ability of brain activity to predict overt behavior. Using functional magnetic resonance imaging (fMRI), we investigated the neural mechanisms underlying behavior during a dynamic decision task that required subjects to select smaller, short-term monetary payoffs in order to receive larger, long-term gains. The number of trials over which the longterm gains accrued was manipulated experimentally (2 versus 12). Event-related neural activity in right lateral prefrontal cortex, a region associated with high-level cognitive processing, selectively predicted choice behavior in both conditions, whereas insular cortex responded to fluctuations in amount of reward but did not predict choice behavior. These results demonstrate the utility of a functional neuroimaging approach in behavioral psychology, showing that (a) highly circumscribed brain regions are capable of predicting complex choice behavior, and (b) fMRI has the ability to dissociate the contributions of different neural mechanisms to particular behavioral tasks.     

Digital chameleons: automatic assimilation of nonverbal gestures in immersive virtual environments

Previous research demonstrated social influence resulting from mimicry (the chameleon effect); a confederate who mimicked participants was more highly regarded than a confederate who did not, despite the fact that participants did not explicitly notice the mimicry. In the current study, participants interacted with an embodied artificial intelligence agent in immersive virtual reality. The agent either mimicked a participant's head movements at a 4-s delay or utilized prerecorded movements of another participant as it verbally presented an argument. Mimicking agents were more persuasive and received more positive trait ratings than nonmimickers, despite participants' inability to explicitly detect the mimicry. These data are uniquely powerful because they demonstrate the ability to use automatic, indiscriminate mimicking (i.e., a computer algorithm blindly applied to all movements) to gain social influence. Furthermore, this is the first study to demonstrate social influence effects with a nonhuman, nonverbal mimicker.