Reduction in rat phosphatidylethanolamine binding protein-1 (PEBP1) after chronic corticosterone treatment may be paralleled by cognitive impairment: a first study

Chronic stress is associated with hippocampal atrophy and cognitive dysfunction. This study investigates how long-lasting administration of corticosterone as a mimic of experimentally induced stress affects psychometric performance and the expression of the phosphatidylethanolamine binding protein (PEBP1) in the adult hippocampus of one-year-old male rats. Psychometric investigations were conducted in rats before and after corticosterone treatment using a holeboard test system. Rats were randomly attributed to 2 groups (n = 7) for daily subcutaneous injection of either 26.8 mg/kg body weight corticosterone or sesame oil (vehicle control). Treatment was continued for 60 days, followed by cognitive retesting in the holeboard system. For protein analysis, the hippocampal proteome was separated by 2D electrophoresis (2DE) followed by image processing, statistical analysis, protein identification via peptide mass fingerprinting and gel matching and subsequent functional network mapping and molecular pathway analysis. Differential expression of PEBP1 was additionally quantified by Western blot analysis. Results show that chronic corticosterone significantly decreased rat hippocampal PEBP1 expression and induced a working and reference memory dysfunction. From this, we derive the preliminary hypothesis that PEBP1 may be a novel molecular mediator influencing cognitive integrity during chronic corticosterone exposure in rat hippocampus.     

An analogy between Hegel's theory of recognition and Ficino's theory of love

A widely debated question in current research centres on determining the precursors to G. W. F. Hegel's theory of recognition. Until now Fichte, Rousseau and Aristotle have been discussed. However, the present paper analyses a further surprising correspondence between Marsilio Ficino's theory of love and Hegel's theory of recognition. Here it is shown that Hegel studied Ficino in 1793 and that we can discover syntactical, semantical, and structural vestiges of Ficino's De amore II 8 in Hegel's early fragments on religion (1793) and love (1797), which are closely related to the general theory of recognition found in the Phenomenology of Spirit. Not only may this thesis be relevant for Hegel or Ficino scholarship, but it could also be a further indication that social theories with normative content are an integral characteristic of (early) modern self-consciousness.     

Disruption of order information by irrelevant items: a serial recognition paradigm

Irrelevant speech effect (ISE) is defined as a decrement in visually presented digit-list short-term memory performance due to exposure to irrelevant auditory material. Perhaps the most successful theoretical explanation of the effect is the changing state hypothesis. This hypothesis explains the effect in terms of confusion between amodal serial order cues, and represents a view based on the interference caused by the processing of similar order information of the visual and auditory materials. An alternative view suggests that the interference occurs as a consequence of the similarity between the visual and auditory contents of the stimuli. An important argument for the former view is the observation that ISE is almost exclusively observed in tasks that require memory for serial order. However, most short-term memory tasks require that both item and order information be retained in memory. An ideal task to investigate the sensitivity of maintenance of serial order to irrelevant speech would be one that calls upon order information but not item information. One task that is particularly suited to address this issue is serial recognition. In a typical serial recognition task, a list of items is presented and then probed by the same list in which the order of two adjacent items has been transposed. Due to the re-presentation of the encoding string, serial recognition requires primarily the serial order to be maintained while the content of the presented items is deemphasized. In demonstrating a highly significant ISE of changing versus steady-state auditory items in a serial recognition task, the present finding lends support for and extends previous empirical findings suggesting that irrelevant speech has the potential to interfere with the coding of the order of the items to be memorized.     

The Effects of Regulatory Focus on Braking Speed1

According to regulatory focus theory ( Higgins, 1997 ), promotion focus is concerned with accomplishments and aspirations leading to strategic eagerness; whereas prevention focus is concerned with safety and responsibilities leading to strategic vigilance. In this study, we investigate how regulatory focus theory can predict braking behavior in driving. In Study 1, participants' assessed regulatory focus strength as measured by chronic personality differences in regulatory focus predicted braking speed, in that chronic prevention‐oriented participants initiated braking earlier, as compared to promotion‐oriented people. In Study 2, we experimentally induced regulatory focus and showed that induced prevention focus enhanced braking speed (i.e., faster), as compared to induced promotion focus.     

Own-other differences in the realism of some metacognitive judgments

The present study investigated differences in judgments of one's own and others' knowledge (the own-other difference). Consistent with the below-average effect (e.g., Kruger, 1999), our main results showed that the participants gave lower knowledge ratings of their own extent of knowledge than of another person's extent of knowledge (Experiment 1). Furthermore, lower and more realistic judgments were found when the participants judged their own as compared with when judging another person's overall accuracy (frequency judgments) of answering knowledge questions correctly (Experiment 1 and 2). On the basis of these results it is argued that judgmental anchoring may be important also in the context of indirect comparisons, and that previous conclusions of cross-cultural psychology regarding the above-average effect may be oversimplified.     

Profile of cognitive deficits and associations with depressive symptoms and intelligence in chronic early‐onset schizophrenia patients

Cognitive deficits in several domains have been demonstrated in early‐onset schizophrenia patients but their profile and relation to depressive symptoms and intelligence need further characterization. The purpose was to characterize the profile of cognitive deficits in chronic, early‐onset schizophrenia patients, assess the potential associations with depressive symptom severity, and examine whether cognitive deficits within several domains reflect intelligence impairments. This study compared attention, visual‐construction, aspects of visual and verbal memory, and executive functions in chronic, early‐onset schizophrenia patients (mean age = 20.7 years) (N = 18) and healthy controls (N = 38). Schizophrenia diagnoses were established at the time of the patients' first clinical presentation during childhood or adolescence and were confirmed five years later. In the chronic phase of early‐onset schizophrenia, significant deficits were observed in all specific cognitive functions. The profile of cognitive deficits was jagged, and visual‐construction, attention, and one aspect of verbal memory (verbal stories recall) were differentially impaired. Deficits of visual recall, visual recognition, and executive functions were accounted for by deficits in intelligence, while this was not the case for deficits of verbal recall of stories or attention. No significant associations were observed between the severity of cognitive deficits and that of depressive symptoms. Chronic, early‐onset schizophrenia is characterized by a broad and jagged profile of cognitive deficits. Deficits of attention and verbal recall of stories appear not to be accounted for by deficits in intelligence, and the severity of cognitive deficits seems independent from that of depressive symptoms     

Seeing love, or seeing lust: How people interpret ambiguous romantic situations

Interpreting ambiguous situations is a task individuals face on a daily basis. In romantic contexts the accurate interpretation of these situations is of particular importance. In the present set of studies we investigated how level of construal guides individual perception in these cases. When a high level of construal was induced participants likely interpreted a given interpersonal situation as the start or the continuation of a long lasting relationship. When a low level of construal was induced the same situations were more likely interpreted as leading to a one-night stand (in a dating situation) or involving little chance of a common future for both actors (in a break-up situation). In sum, the present studies demonstrate construal level to be a crucial determinant of the interpretation of ambiguous romantic situations. We discuss these findings in relation to the functional independence of love and sex, level of construal, and social perception.     

The memorability of names and the divergent effects of prior experience

Pre-experimental familiarity can have paradoxical effects on episodic memory. Knowledge of the stimulus domain usually enhances memory, but word frequency—a presumed correlate of prior experience—is negatively related to recognition accuracy. The present study examined episodic recognition of names and its relation to two measures of pre-experimental knowledge, name frequency, and fame. Frequency was operationalised as the number of hits in a national telephone directory, and fame as hits on national mass media websites. Recognition accuracy was increased by fame, but diminished by frequency. Four experiments confirmed the findings, using yes/no recognition, ROC curves, and remember-know paradigms. Hit rates were consistently more strongly influenced by fame than by frequency, whereas the reverse was true for false alarm rates. These dissociations suggest that two different forms of semantic memory, specific and nonspecific knowledge, interact with episodic memory in separate ways.     

Inhibition and working memory in young preschool children with symptoms of ADHD and/or oppositional-defiant disorder

Background: Early symptoms of attention deficit/hyperactivity disorder (ADHD) and oppositional-defiant disorder (ODD) are associated with deficits in cognitive self-regulatory processes or executive functions (EF)s. However, the hypothesis that neurocognitive deficits underlying the two disorders are already evident during early preschool years still has limited empirical support. The present study investigated associations between symptoms of ADHD and/or ODD and two core EFs, inhibition and working memory, in a large nonclinical sample of 3-year old children. Method: Participants were 1045 children (554 boys, age 37–47 months), recruited from the population based Norwegian Mother and Child Cohort Study (MoBa). Relations between behavioral symptoms and measures of inhibition and working memory were studied both categorically and dimensionally. Results: Children with co-occurring symptoms of ADHD and ODD performed at a significantly lower level than typically developing children in 4 out of 5 EF measures. Symptoms of ADHD, both alone and in combination with ODD, were associated with reduced performance on tests of inhibition in the group comparisons. Dimensional analyses showed that performance within both EF domains contributed to variance primarily in ADHD symptom load. The associations between test results and behavioral symptoms remained significant after gender and verbal skills had been controlled. Conclusion: Young preschoolers show the same pattern of relations between EF and behavioral symptoms of ADHD and/or ODD as previously described in older children diagnosed with ADHD and/or ODD. Effect sizes were generally small, indicating that measures of EF have limited clinical utility at this stage in development.