Legal and ethical issues in neuroimaging research: human subjects protection,medical privacy,and the public communication of research results

Humans subjects research entails significant legal and ethical obligations. Neuroimaging researchers must be familiar with the requirements of human subjects protection, including evolving standards for the protection of privacy and the disclosure of risk in "non-therapeutic" research. Techniques for creating veridical surface renderings from volumetric anatomical imaging data raise new privacy concerns, particularly under the federal medical privacy regulation. Additionally, neuroimaging researchers must consider their obligation to communicate research results responsibly. The emerging field of neuroethics should strive to raise awareness of these issues and to involve neuroimaging researchers in the legal, ethical, and policy debates that currently surround human subjects research.     

Diagnostic validity statistics and the MCMI-III

This article (a) describes and illustrates the nonredundant and clinically important information that may be obtained from 5 diagnostic validity statistics (DVSs): incremental validities of positive and negative test diagnoses, Cohen's kappas, Cohen's effect sizes, and areas under receiver operating characteristic (ROC) curves and (b) determines values of these DVSs for 24 Million Multiaxial Clinical Inventory III scales from results reported in 1994 and 1997 validity studies. The DVSs for the 1997 study (T. Millon, R. Davis, & C. Millon, 1997) were often more than 3 times larger than corresponding DVSs for the 1994 study (T. Millon, 1994). The author suggests these large differences could reflect not only effects of factors that caused underestimation of validities by DVSs of the 1994 study, but also effects of factors that may have caused overestimation of validities by DVSs of the 1997 study.     

A Sustainable Medicine: Lessons from the Old Order Amish

Daniel Callahan's concept of a sustainable medicine is examined by looking at experiences Old Order Amish communities have had with organ and bone marrow transplantation. The Amish possess many characteristics that might make them embrace limits on the use of expensive, life-prolonging medical treatments: they believe that the good of the individual should be subordinated to the good of the community, they are suspicious of progress as a goal, and they are more comfortable with dying than many other modern Americans. However, the Amish actively pursue these treatments without the benefit of private or government insurance. Although the Amish affective response to sick individuals is worthy of emulating, their commitment to help individuals obtain and pay for transplants has had negative financial and cultural effects on some Amish communities. The Amish experience can thus teach us lessons about how to care for one another when we are sick and dying, but it can also teach us how difficult but important it is to limit some forms of expensive care for the good of our communities.     

Windowed cross-correlation and peak picking for the analysis of variability in the association between behavioral time series

Cross-correlation and most other longitudinal analyses assume that the association between 2 variables is stationary. Thus, a sample of occasions of measurement is expected to be representative of the association between variables regardless of the time of onset or number of occasions in the sample. The authors propose a method to analyze the association between 2 variables when the assumption of stationarity may not be warranted. The method results in estimates of both the strength of peak association and the time lag when the peak association occurred for a range of starting values of elapsed time from the beginning of an experiment.     

The generalization of deferred imitation in enculturated chimpanzees (Pan troglodytes)

Deferred imitation of object-related actions and generalization of imitation to similar but not identical tasks was assessed in three human-reared (enculturated) chimpanzees, ranging in age from 5 to 9 years. Each ape displayed high levels of deferred imitation and only slightly lower levels of generalization of imitation. The youngest two chimpanzees were more apt to generalize the model's actions when they had displayed portions of the target behaviors at baseline, consistent with the idea that learning is more likely to occur when working within the "zone of proximal development." We argue that generalization of imitation is the best evidence to date of imitative learning in chimpanzees. Electronic Publication     

Do Coping Styles Differ Across Sociocultural Groups? The Role of Measurement Equivalence in Making This Judgment

Cross-sociocultural group measurement equivalency is an important issue that generally has not been studied in the coping literature. Measurement equivalency of the COPE (Carver, Scheier, & Weintraub, 1989) was assessed across two sociocultural groups, a sample of 100 Anglo middle-class divorced mothers and a sample of 122 low-income Mexican American/Mexican immigrant mothers. A series of restrictive confirmatory factor analyses revealed that seven of the COPE's subscales may be measuring the same underlying construct across populations. However, scores derived from the subscales may not represent the same magnitude of the construct in these two groups. This study makes an important first step in furthering the understanding of coping strategies in low-income Mexican American/Mexican immigrant mothers. This study also illustrates the importance of testing for measurement equivalency before conducting comparative research in disparate populations.     

Contextual effects on word production: A lifespan study

The effect of sentence priming on picture naming was investigated across the lifespan, from age 3 to 87 years. Names that are normally acquired before 3 years of age were presented in auditory contexts that were semantically congruent, incongruent, or neutral in relation to each picture and its name. Sentential priming was present at all age levels. Facilitation (neutral vs. congruent) was significantly by 4 years of age and did not vary significantly with age. Interference (incongruent vs. neutral) was significant at all age levels, but changed nonmonotonically with age (largest in the youngest children, stable from young adulthood through age 70, with a small increase in the oldest participants). We conclude that picture naming is a useful tool for the investigation of sentential priming effects across the lifespan and that it can reveal potentially interesting developmental changes in the effects of sentential context on word retrieval.     

Beyond Speech Lateralization: A Review of the Variability, Reliability, and Validity of the Intracarotid Amobarbital Procedure and Its Nonlanguage Uses in Epilepsy Surgery Candidates

While the intracarotid amobarbital procedure (IAP) was originally utilized to lateralize speech functions as an aid in the surgical treatment of epilepsy, additional uses for the IAP have emerged including: (1) the use of the IAP to predict post-surgical memory changes, including both global amnesia and smaller, yet significant, material-specific memory deficits; (2) the use of the IAP to provide confirmatory evidence of lateralization of seizure focus; and (3) the use of the IAP to predict post-surgical relief from seizures. While the literature on the IAP is extensive and growing, its utility is marred by the wide variability associated with the procedure itself from epilepsy center to center. This variability renders comparisons among IAP studies problematic and conclusions about IAP efficacy difficult. The variability associated with the amobarbital procedures, as well as the reliability and the validity of the IAP in its nonlanguage uses is reviewed here. A special emphasis is devoted to research conducted in the last decade. Also discussed is the future of the IAP including anticipated research directions.     

Estimation of Wechsler Adult Intelligence Scale-III index scores with the 7-subtest short form in a clinical sample

A 7-subtest short form of the Wechsler Adult Intelligence Scale-III (WAIS-III) previously demonstrated good comparability in estimating Full Scale and Verbal IQ summary scores, with adequate comparability in estimating Performance IQ. In a mixed clinical sample of 295 patients, the current study assessed the equivalence of the index scores generated from the full and prorated WAIS-III. The results revealed correlations corrected for redundancy of .90, .86, .87, and .75 for the Verbal Comprehension (VCI), Perceptual Organization (POI), Working Memory (WMI), and Processing Speed (PSI) indexes, respectively. Although the 7-subtest short form of the WAIS-III was not designed to estimate index scores, adequate estimates are viable for VCI, POI, and WMI when the goal is to obtain group, rather than individual, data points.     

Observations on the factor structure of the WAIS-R

Confirmatory factor analyses (CFAs) revealed 2 important characteristics of the standardization data of the Wechsler Adult Intelligence Scale Revised. One finding was that Digit Symbol fit better on an attentional factor in younger groups, but fit was better when Digit Symbol loaded on a visual-perceptual factor in older groups. A second observation was that specifying correlated errors or a fourth factor to explain covariance between Block Design and Object Assembly improved model fit in all age groups except 70- to 74-year-olds. The results illustrate the value of CFA and have implications for investigating other samples and other Wechsler tests.