The role of compliance in hypnotic and nonhypnotic analgesia

We modified the standard procedure for administering finger pressure pain in order to assess the extent to which subjects biased their reports of pain reduction when exposed to compliance-inducing instructions. Experiment 1 used only highly hypnotizable subjects and found that compliance-induced reductions in reported pain were about half as large as the reported reductions produced by hypnotic analgesia suggestions. Experiment 2 used low as well as high hypnotizables and administered hypnotic or nonhypnotic analgesia instructions and compliance instructions to the same subjects on separate pain trials. Reported pain reductions produced by hypnotic and nonhypnotic analgesia suggestions and those produced by compliance instructions were substantially and significantly correlated. Furthermore, hypnotizability correlated with compliance-induced reported pain reductions as highly as it correlated with the reported reductions produced by hypnotic analgesia suggestions. Among high hypnotizables (but not low hypnotizables) compliant responding was predicted by social desirability. The findings of both studies indicate that compliance strongly influences the reports of hypnotic and nonhypnotic analgesia proffered by high hypnotizables. The role of compliance in the pain reductions reported by low hypnotizables is less clear-cut.     

Syntactic comprehension in Japanese aphasics: effects of category and thematic role order.

Syntactic comprehension disturbances in Japanese aphasics were investigated focusing on the role of category order and thematic role order. The data from Japanese aphasics show that the canonicity of thematic role order determines the ease of interpretation of different sentence types. This finding implies that language-specific factors, rather than language-universal factors, influence the sentence comprehension mechanisms that are retained by aphasic patients.     

AIDS prevention for intravenous drug users in the community: Street-based education and risk behavior

Conducted a study of behavior change associated with a street-based AIDS education project targeted to intravenous (IV) drug users in San Francisco. Two cross-sections were sampled from drug detoxification clinics and street locations in 1986 (n = 438) and 1987 (n = 623). Significant increases were reported in the percentage of IV drug users who used bleach to decontaminate syringes, who did not share needles in past year, and in condom use. A significant reduction in an index of the number of needle-sharing partners was reported. Respondents ranked treatment program as most important source of AIDS information prior to implementation of the program, and ranked outreach workers as most important after implementation. Findings suggest that this community-based outreach program had at least some impact on knowledge about AIDS and may have led to reductions in behaviors known to transmit HIV.     

The predictive validity of teacher nominations: A five-year followup of at-risk youth

The purpose of this study was to examine the predictive validity of a teacher nomination procedure for identifying at- risk children. Two hundred and twenty-five children were nominated by their teachers as well- adjusted (n= 75), socially withdrawn (n=76), or socially aggressive (n=74) during the fourth grade. Five years later, 198 of these children (88%) were located and their adjustment evaluated. Significant differences among the nominated children were found on a variety of measures, including academic grades, sociometric status, and social behavior. In addition, differences in school dropout and delinquent offenses were noted. Results are discussed in terms of the validity of teacher nomination procedures and their utility in identifying at- risk youth.     

Rate variables and automatized naming in developmental dyslexia

The rate variable in rapid automatized naming (RAN) was investigated in 50 adolescent and 40 adult students with developmental dyslexia, in matched normal controls, and in learning-disabled students without reading difficulties. Visual stimuli depicting familiar colors and common objects were presented in isolation at three film speeds and three exposure times. Film speed and exposure time contributed as independent variables to error rate; and dyslexic subjects of both age groups made significantly more naming errors than controls. Dyslexic subjects also responded with longer naming latencies than controls when the same RAN stimuli were presented in a continuous sequential mode as a matrix of rows and columns. Naming latencies in the sequential presentation were highly correlated with naming errors in the film version. The implications of reduced naming rates for nongraphological stimuli in developmental dyslexia are discussed.     

Stimulus repetition effects and the dimension-feature distinction in alternative targets

The negative repetition effect (NRE) refers to a poorer perception of the target in noise-same-as-target than in noise-alternative-target displays. Using the parenthesis as target and noise that are either identical or different in orientation, we tested predictions derived from a feature-specific inhibition model (Bjork & Murray, 1977) that explains the NRE as arising from inhibitory interactions among channels handling identical inputs. Contrary to our expectation of evidence for orientation-specific inhibition, a positive repetition effect (PRE) was observed. We also found a PRE for the dimension target sets whose stimuli differ only in orientation and an NRE for the feature target sets whose stimuli differ in the number of elements. Further experiments that systematically varied relationships between alternative targets indicate that these basic findings, termed the stimulus attributes effects, do not arise from pattern masking, perceptual strategies, or response bias.     

The effects of right hemisphere damage on the pragmatic interpretation of conversational remarks

The ability to interpret conversational utterances was assessed in a group of 12 male patients with unilateral right hemisphere brain damage (RHD) and 12 non-brain-damaged, age-matched male control subjects. Subjects listened to short vignettes which described both the affective tone of the relationship between a speaker and an actor, and the actor's performance on a task. Each vignette concluded with the speaker characterizing the actor's performance. In half of the items, the speaker's utterance was literally true; in the other half, the utterance was literally false and invited a nonliteral interpretation. Results showed no appreciable differences in the performance of control subjects and RHD patients when interpreting literally true utterances. In contrast, the two groups differed reliably when interpreting the pragmatic intent of nonliteral utterances: Control subjects used information about both the actor's performance and the speaker-actor relationship, while RHD patients demonstrated difficulty in using the information about the speaker-actor relationship. Results have implications for patients' understanding of essential elements of conversations, such as characters' internal states and their intentions in employing different forms of literal and nonliteral language.     

The ontogeny of hemispheric specialization: some old hypotheses revisited

This paper re-examines two hypotheses on the ontogeny of hemispheric specialization that long ago fell into disfavor in neuropsychology. It is argued that these hypotheses, equipotentiality and progressive lateralization, may have suffered from misinterpretation that fostered premature acceptance of the developmental invariance view of hemispheric specialization. An alternative view is presented that incorporates both hypotheses within a neurodevelopmental context using anatomical (postmortem) and childhood aphasia data.     

Benzodiazepine receptor ligand influences on acquisition: suggestion of an endogenous modulatory mechanism mediated by benzodiazepine receptors

In rats, pretraining ip administration of the central benzodiazepine receptor antagonist, flumazenil (5.0 mg/kg), or of the inverse agonist, n-butyl-beta-carboline-3-carboxylate (BCCB) (0.2 or 0.5 mg/kg), facilitated retention of a step-down inhibitory avoidance task; the central agonists, clonazepam and diazepam (0.4 or 1.0 mg/kg), had an opposite effect, and the peripheral agonist, 4'-chlordiazepam (1.25 or 6.25 mg/kg), was without effect. Pre- but not post-training flumazenil (2.0 mg/kg) blocked the effect of BCCB (0.5 mg/kg), clonazepam (1.0 mg/kg), or diazepam (1.0 mg/kg) given also pretraining. The post-training administration of all of these drugs had no effect on retention of the avoidance task. Flumazenil (5.0 mg/kg) and BCCB (0.5 mg/kg), given before training, enhanced retention test performance of habituation to a buzzer but not of habituation to an open field. In the three tasks studied, none of the drugs used had any appreciable effect on training session parameters. These results suggest that there is an endogenous mechanism mediated by benzodiazepine agonists, sensitive to inverse agonists, that normally down-regulates acquisition of certain behaviors; this mechanism becomes activated only when the tasks involve or occur with a certain degree of stress or anxiety (i.e., inhibitory avoidance or habituation to the buzzer) and not in less stressful or anxiogenic tasks (i.e., habituation to an open field).     

Values and Recovery From Alcoholism Through Alcoholics Anonymous

This report reviews the literature on the values of alcoholics and addicts in treatment and presents data that suggest a shift in values is involved in recovery from alcoholism through participation in Alcoholics Anonymous and that values clarification and value therapy may be useful in chemical dependency treatment.