Cerebral Anesthetization for Localization of Speech: The Contribution of W. James Gardner

In 1949, the neurologist Juhn Wada reported the first use of a new procedure for determining the localization of speech and language in neurological patients: examination of the effects on speech and language after injecting a barbiturate, sodium amytal, into the internal carotid artery of each hemisphere in succession. By the 1960s, Wada'sIntracarotid Amobarbital Procedure,orIAP,had become the method of choice for identifying the speech-dominant side in one kind of neurological patient, persons with epilepsy who are candidates for surgical resection, and it remains so today. In 1941, however, an American neurosurgeon, W. James Gardner, reported his use of a different anesthetization procedure for speech localization in neurological patients. Instead of injecting sodium amytal through the blood supply, as in the IAP, Gardner injected procaine hydrochloride directly into cortical tissue. In this paper, we provide a brief biography of Gardner. We then discuss his method of cortical anesthetization, the theoretical and empirical background guiding his use of this method and his choice of patients, and, finally, the fate of Gardner's method within the scientific community.     

Construct validity and test-retest reliability of a date rape decision-latency measure

In two studies, the construct (convergent and discriminant) validity and test-retest reliability of a date rape decision-latency measure was examined. In Study 1, 174 college men completed measures related to sexual aggression and listened to an audiotaped simulation of a date rape, during which cues of nonconsent and force gradually escalated over time. Participants were instructed to respond, by pressing a button which recorded the latency of their decisions in seconds, if and when they believed the man depicted in the scenario should stop his sexual advances. Results demonstrated positive associations between prolonged decision latencies and sexually aggressive behavior, calloused sexual beliefs, acceptance of interpersonal violence, and sexual promiscuity. In Study 2, initial results were cross-validated in a sample of 102 college men, and discriminant validity was established as decision latencies were unassociated with measures of social desirability, alcohol consumption and drug use. Test-retest reliability assessed over a 2-week interval was .87.The authors wish to thank Alan Gross and Brian Marx for providing the audiotaped stimulus materials, Richard Marsh for writing the decision-latency computer program, Jason Hicks for assisting with programming, and the undergraduate research assistants for serving as experimenters.     

Correspondence

The American Journal of Psychoanalysis -     

A transformation of self-discrimination response functions in accordance with the arbitrarily applicable relations of sameness, more than, and less than

In Experiment 1, 2 experimental subjects were given pretraining of nonarbitrary relations that brought their responses under the control of four contextual stimuli; same, opposite, more than, and less than. One control subject was not exposed to this pretraining. The 2 pretrained subjects and the 3rd nonpretrained subject then received training in six arbitrary relations, the following four relations being the most critical: same/A1-B1, same/A1-C1, less than/A1-B2, more than/A1-C2. All 3 subjects were then tested for seven derived relations, the following three relations being the most important: same/B1-C1, more than/B1-C2, less than/B1-B2. The 2 pretrained subjects, but not the nonpretrained subject, showed the derived relations. One of the stimuli (B1) from the relational network and two novel stimuli (X1 and X2) were then used to train three different self-discrimination responses on three complex schedules of reinforcement. That is, all 3 subjects were trained to pick X1 if they had not emitted a response, to pick B1 if they had emitted one response only, and to pick X2 if they had emitted two responses only. The 2 pretrained subjects, but not the nonpretrained subject, showed the predicted transformation of self-discrimination response functions in accordance with the relations of sameness, more than, and less than (i.e., no response, pick B2; one response only, pick C1; and two responses only, pick C2). In Experiment 2, 2 new subjects were employed, and the arbitrary relational training and testing phases were modified to control for a procedural artifact that may have contributed to the results of the first experiment. Experiment 2 replicated the findings of Experiment 1. The pattern of results support the utility of a relational frames approach to understanding derived stimulus relations.     

The distribution postulate in Bohm's theory

On Bohm's formulation of quantum mechanics particles always have determinate positions and follow continuous trajectories. Bohm's theory, however, requires a postulate that says that particles are initially distributed in a special way: particles are randomly distributed so that the probability of their positions being represented by a point in any regionR in configuration space is equal to the square of the wave-function integrated overR. If the distribution postulate were false, then the theory would generally fail to make the right statistical predictions. Further, if it were false, then there would at least in principle be situations where a particle would approach an eigenstate of having one position but in fact always be somewhere very different. Indeed, we will see how this might happen even if the distribution postulate were true. This will help to show how loose the connection is between the wave-function and the positions of particles in Bohm's theory and what the precise role of the distribution postulate is. Finally, we will briefly consider two attempts to formulate a version of Bohm's theory without the distribution postulate.     

The mediating role of anxiety in self-reported somatic complaints of depressed adolescents

This study examined the mediating role of anxiety in the self-reports of somatic complaints in 96 depressed adolescent inpatients. Sixty-four subjects with major depressive episodes and comorbid anxiety disorders (MDE-A) determined from the Diagnostic Interview for Children and Adolescents-Revised (DICA-R) reported significantly more somatic complaints than 32 adolescents having major depressive episodes without comorbid anxiety (MDE). An analysis of covariance demonstrated that, with anxiety symptoms controlled, MDE and MDE-A groups did not differ significantly in somatic complaints. A hierarchical multiple-regression analysis revealed that, with demographic and anxiety symptoms controlled, depressive symptoms did not contribute to the explanation or prediction of somatic complaints. The results suggest that anxious, but not depressive symptoms, are independently associated with somatic complaints. The results are discussed in light of new affective models of psychopathology.     

Contextual influences on interactive processing: Effects of discriminability,quantity, and uncertainty

Three contextual factors—(1) the discriminability of stimuli in pitch, (2) the number of stimuli differing in pitch, and (3)the uncertainty regarding which stimuli or tasks would appear—were manipulated as subjects performed speeded loudness classifications in each of six experiments. The magnitude of Garner interference and effects of congruity were used to gauge the degree of interactive processing. Enhancing pitch discriminability caused monotonic increases in interference and congruity. Stimulus-task uncertainty mediated the changes in Garner interference wrought by increased discriminability. Uncertainty also caused a surprising shift in congruity from strongly positive to strongly negative as uncertainty grew. Increasing stimulus quantity lowered interference, but had inconsistent effects on congruity. Regression analyses suggested that, collectively, these three contextual variables underlie most failures of selective attention in speeded classification.     

Measuring and predicting the effects of alcohol consumption on contrast sensitivity for stationary and moving gratings

Contrast sensitivity was measured for 12 healthy young males while sober, after ingestion of an alcohol placebo, and after ingestion of alcohol (95% grain alcohol; mean estimated blood alcohol level = .088%). Observations were made for both stationary gratings and gratings that traveled through a circular path and required pursuit eye movements. The significant alcohol-related reduction in contrast sensitivity was 2.6 times greater for moving (.29-log-unit reduction) than for stationary gratings (.11-log-unit reduction). The loss in contrast sensitivity for the moving gratings of high spatial frequency (12 cpd) was particularly severe (.37 log unit). Estimated blood alcohol level was correlated with the loss in contrast sensitivity for moving gratings (r = .61), but not with the loss for stationary gratings. Estimated blood alcohol level was strongly correlated with the difference between the loss in contrast sensitivity to moving and stationary gratings (r = .75). These results are consistent with reports that alcohol consumption degrades the ability to make pursuit eye movements. Subjects’ perceived intoxication level was not a reliable predictor of any index of visual performance.