Acquired epileptiform aphasia: a dimensional view of Landau-Kleffner syndrome and the relation to regressive autistic spectrum disorders.

Acquired epileptiform aphasia (AEA) is characterized by deterioration in language in childhood associated with seizures or epileptiform electroencephalographic abnormalities. Despite an extensive literature, discrepancies and contradictions surround its definition and nosological boundaries. This paper reviews current conceptions of AEA and highlights variations in the aphasic disturbance, age of onset, epileptiform EEG abnormalities, temporal course, and long-term outcome. We suggest that AEA, rather than being a discrete entity, is comprised of multiple variants that have in common the features of language regression and epileptiform changes on EEG. Viewed this way, we argue that AEA can be conceptualized on a spectrum with other epileptiform neurocognitive disorders that may share pathophysiological features. The implications of this viewpoint are discussed, with emphasis on parallels between the AEA variants and regressive autistic spectrum disorders.     

Does Conscientiousness Moderate the Relationship Between Attitudes and Beliefs Regarding Performance Appraisal and Rating Behavior?

Attitudes, beliefs, and orientations of 253 managers toward performance appraisal, along with the personality dimension conscientiousness, were used to predict rating behavior (i.e., mean ratings and measures of performance dimensions discrimination and ratee discrimination). As predicted, relationships between rater attitudes and rating behavior were moderated by conscientiousness; correlations between the attitudes and rating behavior were strongest for raters who were relatively low on conscientiousness.     

Subcellular Interactions between Parallel Fibre and Climbing Fibre Signals in Purkinje Cells Predict Sensitivity of Classical Conditioning to Interstimulus Interval

Classical conditioning of the nictitating membrane response requires a specific temporal interval between conditioned stimulus and unconditioned stimulus, and produces an increase in Protein Kinase C (PKC) activation in Purkinje cells. To evaluate whether biochemical interactions within the Purkinje cell may explain the temporal sensitivity, a model of PKC activation by Ca2+, diacylglycerol (DAG), and arachidonic acid (AA) is developed. Ca2+ elevation is due to CF stimulation and IP3 induced Ca2+ release (IICR). DAG and IP3 result from PF stimulation, while AA results from phospholipase A2 (PLA2). Simulations predict increased PKC activation when PF stimulation precedes CF stimulation by 0.1 to 3 s. The sensitivity of IICR to the temporal relation between PF and CF stimulation, together with the buffering system of Purkinje cells, significantly contribute to the temporal sensitivity.     

Postoperative Cognitive Dysfunction Versus Complaints: A Discrepancy in Long-Term Findings

This review describes the discrepancy in findings between postoperative cognitive performance and postoperative cognitive complaints long time after an operation under general anesthesia. Shortly (from 6 hr to 1 week) after an operation a decline in cognitive performance is reported in most studies. However, long time (from 3 weeks to 1–2 years) after an operation this is rarely found although some patients are still reporting cognitive complaints. In general this kind of research is suffering from severe methodological problems (use of insensitive tests, lack of control groups, lack of parallel tests, different definitions of cognitive decline). However, these problems cannot totally explain the discrepancy in findings in the long term. Thus, there are patients who have persistent cognitive complaints long time after an operation, that cannot be measured with cognitive tests. More psychological factors such as fixation on short-term cognitive dysfunction, mood, coping style, and personality are possible explanations for these cognitive complaints in the long term. As a consequence, these factors should be a topic in future research elucidating the persistence of these cognitive complaints long time after an operation under general anesthesia.     

Subcellular interactions between parallel fibre and climbing fibre signals in purkinje cells predict sensitivity of classical conditioning to interstimulus interval

Classical conditioning of the nictitating membrane response requires a specific temporal interval between conditioned stimulus and unconditioned stimulus, and produces an incrase in Protein Kinase C (PKC) activation in Purkinje cells. To evaluate whether biochemical interactions within the Purkinje cell may explain the temporal sensitivity, a model of PKC activation byCa ²⁺, diacylglycerol (DAG), and arachidonic acid (AA) is developed.Ca ²⁺ elevation is due to CF stimulation and IP3 inducedCa ²⁺ release (IICR). DAG andIP ₃ result from PF stimulation, while AA results from phospholipase A2 (PLA ₂). Simulations predict increased PKC activation when PF stimulation precedes CF stimulation by 0.1 to 3 s. The sensitivity of IICR to the temporal relation between PF and CF stimulation, together with the buffering system of Purkinje cells, significantly contribute to the temporal sensitivity.     

Self-reported delinquency among Alberta's youth: findings from a survey of 2,001 junior and senior high school students

This article draws on data from a 1999 survey on youth victimization, crime and delinquency in Alberta conducted by the Canadian Research Institute for Law and the Family in collaboration with researchers from the University of Alberta. The survey included 2,001 youth attending Grades 7 to 12 in public and Catholic schools in selected urban and rural areas in the province. Analyses focus on self-reported past-year delinquency. Statistically significant results were found for relationships between extent of delinquency and gender, grade level, psychosocial problems (as measured by conduct, hyperactivity, and emotional problems), and extent of past-year victimization. For low/moderate delinquency, females were comparable to males, and even reported slightly higher rates for low/moderate violence-related delinquency. Younger students were more likely to indicate engaging in violence-related delinquency, while older students were more likely to report property-related delinquent acts. Overall, Grade 9 students had the highest rates of delinquency. For personal characteristics, a high score on conduct problems was most strongly correlated with moderate/high delinquency. The relationship between high levels of delinquency and victimization was stronger for violence-related delinquency than for property-related delinquency.     

What's Critical about Vulnerability? Rethinking Interdependence,Recognition, and Power

Images of vulnerability have populated the philosophical landscape from Hobbes to Hegel, Levinas to Foucault, often designating a sense of corporeal susceptibility to injury, or of being threatened or wounded and therefore have been predominantly associated with violence, finitude, or mortality. More recently, feminist theorists such as Judith Butler and Adriana Cavarero have begun to rethink corporeal vulnerability as a critical or ethical category, one based on our primary interdependence and intercorporeality. However, many contemporary theorists continue to associate vulnerability with violence and finitude rather than providing an account of the normative theory that might underpin vulnerability as a critical category. In this article, I explore an alternative notion of vulnerability in relation to both a theory of power and a normative account that draws on recognition theory. My aim in this article is twofold: first, to examine the complexity of vulnerability and how it relates to forms of recognition; second, to outline how the notion of vulnerability can operate as the basis for critiquing objectionable forms of vulnerability. This is to consider vulnerability not only as an ethical or ontological question but as a political one, and shifts arguments about its abuse and entanglement with power and violence to the public political sphere.     

Testing the associative-link hypothesis in immediate serial recall: Evidence from word frequency and word imageability effects

Two immediate serial recall experiments were conducted to test the associative-link hypothesis (Stuart & Hulme, 2000). We manipulated interitem association by varying the intralist latent semantic analysis (LSA) cosines in our 7-item study word lists, each of which consists of high- or low-frequency words in Experiment 1 and high- or low-imageability words in Experiment 2. Whether item recall performance was scored by a serial-recall or free-recall criterion, we found main effects of interitem association, word imageability, and word frequency. The effect of interitem association also interacted with the word frequency effect, but not with the word imageability effect. The LSA-cosinexword frequency interaction occurred in the recency, but not primacy, portion of the serial position curve. The present findings set explanatory boundaries for the associative-link hypothesis and we argue that both item- and associative-based mechanisms are necessary to account for the word frequency effect in immediate serial recall.