Subcellular Interactions between Parallel Fibre and Climbing Fibre Signals in Purkinje Cells Predict Sensitivity of Classical Conditioning to Interstimulus Interval

Classical conditioning of the nictitating membrane response requires a specific temporal interval between conditioned stimulus and unconditioned stimulus, and produces an increase in Protein Kinase C (PKC) activation in Purkinje cells. To evaluate whether biochemical interactions within the Purkinje cell may explain the temporal sensitivity, a model of PKC activation by Ca2+, diacylglycerol (DAG), and arachidonic acid (AA) is developed. Ca2+ elevation is due to CF stimulation and IP3 induced Ca2+ release (IICR). DAG and IP3 result from PF stimulation, while AA results from phospholipase A2 (PLA2). Simulations predict increased PKC activation when PF stimulation precedes CF stimulation by 0.1 to 3 s. The sensitivity of IICR to the temporal relation between PF and CF stimulation, together with the buffering system of Purkinje cells, significantly contribute to the temporal sensitivity.     

Postoperative Cognitive Dysfunction Versus Complaints: A Discrepancy in Long-Term Findings

This review describes the discrepancy in findings between postoperative cognitive performance and postoperative cognitive complaints long time after an operation under general anesthesia. Shortly (from 6 hr to 1 week) after an operation a decline in cognitive performance is reported in most studies. However, long time (from 3 weeks to 1–2 years) after an operation this is rarely found although some patients are still reporting cognitive complaints. In general this kind of research is suffering from severe methodological problems (use of insensitive tests, lack of control groups, lack of parallel tests, different definitions of cognitive decline). However, these problems cannot totally explain the discrepancy in findings in the long term. Thus, there are patients who have persistent cognitive complaints long time after an operation, that cannot be measured with cognitive tests. More psychological factors such as fixation on short-term cognitive dysfunction, mood, coping style, and personality are possible explanations for these cognitive complaints in the long term. As a consequence, these factors should be a topic in future research elucidating the persistence of these cognitive complaints long time after an operation under general anesthesia.     

Subcellular interactions between parallel fibre and climbing fibre signals in purkinje cells predict sensitivity of classical conditioning to interstimulus interval

Classical conditioning of the nictitating membrane response requires a specific temporal interval between conditioned stimulus and unconditioned stimulus, and produces an incrase in Protein Kinase C (PKC) activation in Purkinje cells. To evaluate whether biochemical interactions within the Purkinje cell may explain the temporal sensitivity, a model of PKC activation byCa ²⁺, diacylglycerol (DAG), and arachidonic acid (AA) is developed.Ca ²⁺ elevation is due to CF stimulation and IP3 inducedCa ²⁺ release (IICR). DAG andIP ₃ result from PF stimulation, while AA results from phospholipase A2 (PLA ₂). Simulations predict increased PKC activation when PF stimulation precedes CF stimulation by 0.1 to 3 s. The sensitivity of IICR to the temporal relation between PF and CF stimulation, together with the buffering system of Purkinje cells, significantly contribute to the temporal sensitivity.     

Self-reported delinquency among Alberta's youth: findings from a survey of 2,001 junior and senior high school students

This article draws on data from a 1999 survey on youth victimization, crime and delinquency in Alberta conducted by the Canadian Research Institute for Law and the Family in collaboration with researchers from the University of Alberta. The survey included 2,001 youth attending Grades 7 to 12 in public and Catholic schools in selected urban and rural areas in the province. Analyses focus on self-reported past-year delinquency. Statistically significant results were found for relationships between extent of delinquency and gender, grade level, psychosocial problems (as measured by conduct, hyperactivity, and emotional problems), and extent of past-year victimization. For low/moderate delinquency, females were comparable to males, and even reported slightly higher rates for low/moderate violence-related delinquency. Younger students were more likely to indicate engaging in violence-related delinquency, while older students were more likely to report property-related delinquent acts. Overall, Grade 9 students had the highest rates of delinquency. For personal characteristics, a high score on conduct problems was most strongly correlated with moderate/high delinquency. The relationship between high levels of delinquency and victimization was stronger for violence-related delinquency than for property-related delinquency.     

Testing the associative-link hypothesis in immediate serial recall: Evidence from word frequency and word imageability effects

Two immediate serial recall experiments were conducted to test the associative-link hypothesis (Stuart & Hulme, 2000). We manipulated interitem association by varying the intralist latent semantic analysis (LSA) cosines in our 7-item study word lists, each of which consists of high- or low-frequency words in Experiment 1 and high- or low-imageability words in Experiment 2. Whether item recall performance was scored by a serial-recall or free-recall criterion, we found main effects of interitem association, word imageability, and word frequency. The effect of interitem association also interacted with the word frequency effect, but not with the word imageability effect. The LSA-cosinexword frequency interaction occurred in the recency, but not primacy, portion of the serial position curve. The present findings set explanatory boundaries for the associative-link hypothesis and we argue that both item- and associative-based mechanisms are necessary to account for the word frequency effect in immediate serial recall.     

Exposure to Violence, Support Needs, Adjustment, and Motivators Among Guatemalan Humanitarian Aid Workers

Indigenous aid workers carry out the majority of humanitarian aid work, yet there is little empirical information available on their support needs in different contexts. Focus groups (N = 26: Study 1) and a survey (N = 137; Study 2) were conducted with Guatemalan aid workers to explore their exposure to violence, posttraumatic stress symptoms, burnout, support needs, and motivators. Participants reported experiencing an average of 13 events of community violence and 17% reported symptoms consistent with posttraumatic stress disorder (PTSD). Direct community violence exposure and levels of emotional exhaustion were positively related to PTSD symptoms, while levels of personal accomplishment were inversely related to PTSD symptoms. Expressed support needs, motivators and rewards for aid work in the face of adversity are also reported as potential protective factors for further exploration. Implications for training and support of aid workers in similar contexts are also suggested.     

Changing Marriage Role Expectations: 1961–1996

The present study is an update of a longitudinal study of marriage role expectations begun in 1961. Data collected in 1990 and 1996 have been added to the data set, allowing for comparisons of female college students' marriage role expectations from 1961, 1972, 1978, 1984, 1990, and 1996. Comparisons include the females' traditional vs. egalitarian expectations for their marriage overall as well as on the seven subscales of authority, homemaking, child care, personal characteristics, social participation, education, and employment and support. There were significant changes toward more egalitarian expectations overall and on all subscales except authority from 1961 to 1972. Since 1972, the only significant changes were on the subscales of authority, homemaking, and child care, with no significant changes on any subscales or on overall expectations since 1978.