Assessing and interpreting personality change and continuity in patients treated for major depression

Structural, mean- and individual-level, differential, and ipsative personality continuity were examined in 599 patients treated for major depression assigned to 1 of 6 forms of a 6-month pharmaco-psychotherapy program. Covariation among traits from the Five Factor model remained invariant across treatment, and patients described themselves as slightly more extraverted, open to experience, agreeable and conscientious, and substantially more emotional stable after treatment. Trait changes were only to a small extent explained by changes in depression severity. There was evidence for differential, individual-level, and ipsative stability, with stable personality profiles in terms of shape and to a lesser extent in terms of scatter and elevation. Traits remain relatively stable, except for emotional stability, despite the depressive state and the psychopharmacological interventions.     

Conscious, preconscious, and subliminal processing: a testable taxonomy

Of the many brain events evoked by a visual stimulus, which are specifically associated with conscious perception, and which merely reflect non-conscious processing? Several recent neuroimaging studies have contrasted conscious and non-conscious visual processing, but their results appear inconsistent. Some support a correlation of conscious perception with early occipital events, others with late parieto-frontal activity. Here we attempt to make sense of these dissenting results. On the basis of the global neuronal workspace hypothesis, we propose a taxonomy that distinguishes between vigilance and access to conscious report, as well as between subliminal, preconscious and conscious processing. We suggest that these distinctions map onto different neural mechanisms, and that conscious perception is systematically associated with surges of parieto-frontal activity causing top-down amplification.     

Class specificity and the lexical encoding of participant information

It is commonly assumed across the language sciences that some semantic participant information is lexically encoded and some is not. In this article, we propose that semantic obligatoriness and verb class specificity are criteria which influence whether semantic information is lexically encoded. We present a comprehensive survey of the English verbal lexicon and two continuation studies which confirm that both factors play a role in the lexical encoding of participant information.     

A European perspective on depression in the community: the DEPRES study

Depression is one of the most prevalent disorders in the general population, causing personal and social disability and impairment. Major studies assessing the diagnosis and management of depression have shown that it is often underdiagnosed and undertreated. A pan-European study aimed at assessing the extent and consequences of depression in six different countries is reported in this article. Different types of depressive profiles are analyzed and their respective management has been compared. The importance of improving diagnosis and treatment of depression is underlined. Appropriate management of depression depends on the recognition of depressive symptoms by patients, their possibility of seeking care, and the ability of the primary care physician to recognize the disorder and prescribe the appropriate medicines. Improvement in all of these fields is necessary.     

Visual perception of writing and pointing movements

Studies of movement production have shown that the relationship between the amplitude of a movement and its duration varies according to the type of gesture. In the case of pointing movements the duration increases as a function of distance and width of the target (Fitts' law), whereas for writing movements the duration tends to remain constant across changes in trajectory length (isochrony principle). We compared the visual perception of these two categories of movement. The participants judged the speed of a light spot that portrayed the motion of the end-point of a hand-held pen (pointing or writing). For the two types of gesture we used 8 stimulus sizes (from 2.5 cm to 20 cm) and 32 durations (from 0.2 s to 1.75 s). Viewing each combination of size and duration, participants had to indicate whether the movement speed seemed "fast", "slow", or "correct". Results showed that the participants' perceptual preferences were in agreement with the rules of movement production. The stimulus size was more influential in the pointing condition than in the writing condition. We consider that this finding reflects the influence of common representational resources for perceptual judgment and movement production.     

Plausible Reasoning and the Resolution of Quantifier Scope Ambiguities

Despite overwhelming evidence suggesting that quantifier scope is a phenomenon that must be treated at the pragmatic level, most computational treatments of scope ambiguities have thus far been a collection of syntactically motivated preference rules. This might be in part due to the prevailing wisdom that a commonsense inferencing strategy would require the storage of and reasoning with a vast amount of background knowledge. In this paper we hope to demonstrate that the challenge in developing a commonsense inferencing strategy is in the discovery of the relevant commonsense data and in a proper formulation of the inferencing strategy itself, and that a massive amount of background knowledge is not always required. In particular, we present a very effective procedure for resolving quantifier scope ambiguities at the pragmatic level using simple quantitative data that is readily available in most database environments.     

Word Meaning Frequencies Affect Negative Compatibility Effects In Masked Priming

Negative compatibility effects (NCEs)—that is, slower responses to targets in related than unrelated prime-target pairs, have been observed in studies using stimulus-response (S-R) priming with stimuli like arrows and plus signs. Although there is no consensus on the underlying mechanism, explanations tend to locate NCEs within the motor-response system. A characteristic property of perceptuo-motor NCEs is a biphasic pattern of activation: A brief period in which very briefly presented (typically) masked primes facilitate processing of related targets is followed by a phase of target processing impairment. In this paper, we present data that suggest that NCEs are not restricted to S-R priming with low-level visual stimuli: The brief (50 ms), backward masked (250 ms) presentation of ambiguous words (bank) leads to slower responses than baseline to words related to the more frequent (rob) but not less frequent meaning (swim). Importantly, we found that slowed responses are preceded by a short phase of response facilitation, replicating the biphasic pattern reported for arrows and plus signs. The biphasic pattern of priming and the fact that the NCEs were found only for target words that are related to their prime word’s more frequent meaning has strong implications for any theory of NCEs that locate these effects exclusively within the motor-response system.     

Correlates of Depressive Disorders in the Quebec General Population 6 to 14 Years of Age

There are relatively few community-based epidemiological studies in which correlates of depressive disorders were identified through multivariate analyses in children and adolescents aged 6--14 years. Moreover, several family characteristics (e.g., parent-child relationship) have never been explored in this regard. The purpose of this study was twofold. Using data from the Quebec Child Mental Health Survey, it sought: (1) to identify psychosocial correlates associated with depressive disorder in two age-groups (6--11 and 12-14 years) according to informant (child/adolescent, parent); and (2) to interpret the relative importance of correlates by ranking variables according to strength and consistency of association across age-groups. Logistic regression models show correlates to be inconsistent across informants. The ranking of correlates indicates a major contribution of only-child status/ordinal position, parent's major depressive disorder, stressful family events, and parent-child relationship, thereby supporting the hypothesis of the relevance of family context in the development of depression.     

Outcome evaluation in brief mother-infant psychotherapies: Report on 75 cases

The effects of brief mother–infant psychotherapies (maximum of 10 sessions) were examined in cases of functional and behavioral disturbances in children less than 30 months old. Seventy-five mother-infant dyads were assessed prior to treatment, at 1 week, and 6 months after therapy ended. The outcome measures were changes in the infant's symptoms, the behavioral interactions between mother and infant, and maternal representations. The effect of two forms of intervention—Psychodynamic Therapy and Interaction Guidance Therapy—were compared. Results indicated a significant symptom reduction; dyadic interactions became more harmonious (mothers became less intrusive and infants more cooperative). Maternal self-esteem grew significantly and negative affects decreased. Improvements lasted as least several months, with some positive improvement detected at the 6-month follow-up. No major difference in outcome was found between the effects of the two forms of intervention. Within the limitations of research in a clinical context, this study suggests that brief mother–infant psychotherapies are a cost-effective method of early intervention.     

Does personality disorder co-morbidity impact treatment outcome for patients with major depression? A multi-level analysis

In literature, there exists disagreement regarding the impact of comorbid personality disorder(s) (PD[s]) on treatment outcome for patients with major depressive disorder (MDD). The aim of this paper was to investigate whether statistical heterogeneity and inter-dependency are potential moderators of the effect of co-morbid PDs on outcome for patients with MDD. Clinician-rated MADRS scores and DSM-IV Axis II personality disorder diagnoses were obtained from 562 outpatients with MDD who received 6 months of combined psycho- and pharmacotherapy. Single-level regression showed significantly worse treatment outcome among patients with co-morbid PD, as compared to patients with no PD. After controlling for statistical heterogeneity and interdependency, treatment outcome was no longer significantly worse for patients with co-morbid PD. In conclusion, heteroscedasticity and inter-dependency should be considered as potentially compelling explanations for inconsistencies in findings on treatment outcome for depressed patients with co-morbid PDs.