Language and syntactic impairment following stroke in late bilingual aphasics

Purpose

Bilingual aphasia generally affects both languages. However, the age of acquisition of the second language (L2) seems to play a role in the anatomo-functional correlation of the syntactical/grammatical processes, thus potentially influencing the L2 syntactic impairment following a stroke. The present study aims to analyze the influence of late age of acquisition of the L2 on syntactic impairment in bilingual aphasic patients.

Methods

Twelve late bilingual participants (speaking French as L2 and either English, German, Italian or Spanish as L1) with stroke-induced aphasia participated in the study. The MAST or BAT aphasia batteries were used to evaluate overall aphasia score. An auditory syntactic judgement task was developed and used to test participants syntactic performance.

Results

The overall aphasia scores did not differ between L1 and L2. In a multiple case analysis, only one patient had lower scores in L2. However, four patients presented significantly lower performances in syntactic processing in the late L2 than in their native language (L1). In these four patients the infarct was localized, either exclusively or at least partially, in the pre-rolandic region.

Conclusion

This pilot study suggests that, in late bilingual aphasics, syntactic judgment abilities may be more severely impaired in L2, and that this syntactic deficit is most likely to occur following anterior lesions.     

Cross-structural priming: prepositional phrase attachment primes relative clause attachment

In this paper we show that attachment height (high vs. low attachment) of a modifier to a complex noun phrase (CNP; e.g., "the servant of the actress"), can be primed between dissimilar syntactic structures. In a sentence completion experiment, we found that the attachment height of a prepositional phrase (PP) in the prime sentence primed the attachment height of a relative clause (RC) in the target sentence. This cross-structural priming effect cannot be explained in terms of the priming of specific phrase-structure rules or even sequences of specific phrase-structure rules (Scheepers, 2003), because the attachment of a PP to a CNP is generated by a different phrase-structure rule than the attachment of an RC. However, the present data suggest that the location at which the RC is attached to the CNP is mentally represented, independent of the specific phrase-structure rule that is attached, or by extension, that the abstract hierarchical configuration of the full CNP and the attached RC is represented (Desmet & Declercq, 2006). This is the first demonstration of a cross-structural priming effect that cannot be captured by phrase-structure rules.     

Integrative processing of perception and reward in an auditory localization paradigm

Under natural conditions, human beings routinely have to choose among multiple alternatives which are associated with specific outcomes of varying desirability. Typically, decisions are based upon the processing of perceptual input, which introduces additional noise to the system. Bayesian decision theory (BDT) allows us to formalize decision under risk and to predict statistically optimal choice behavior. In the present study, human observers performed a classification task characterized by an extensive amount of perceptual uncertainty (auditory localization). In addition, a spatial reward function was imposed on the task. We set up a BDT model with no free parameters to serve as a benchmark for statistically optimal choices, and tested it against a purely perceptual model and a hybrid, heuristic model. In addition, we tested these three models with free rather than fixed parameters for the perceptual uncertainty and the peak of the reward function. The log likelihoods of the models given the empirical data were determined by means of Monte Carlo simulations. Bayesian model comparison (BMC) revealed that the BDT model with two free parameters was the most plausible among the tested models. The fitted parameter values for the peak of the reward function were consistently smaller than the actual peak reward communicated to the participants. The results are discussed in the context of an internal underweighting of the reward function.     

Using accelerator pedal force to increase seat belt use of service vehicle drivers

This study evaluated a device that applied a sustained increase in accelerator pedal back force whenever drivers exceeded a preset speed criterion without buckling their seat belts. This force was removed once the belt was fastened. Participants were 6 commercial drivers who operated carpet-cleaning vans. During baseline, no contingency was in place for unbuckled trips. The pedal resistance was introduced via a multiple baseline design across groups. On the first day of treatment, the device was explained and demonstrated for all drivers of the vehicle. The treatment was associated with an immediate sustained increase in seat belt compliance to 100%. Occasionally, drivers initially did not buckle during a trip and encountered the force. In all instances, they buckled within less than 25 s. These results suggest that the increased force was sufficient to set up an establishing operation to reinforce seat belt buckling negatively. Drivers indicated that they were impressed with the device and would not drive very long unbelted with the pedal force in place.     

Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission

We evaluated various forms of hippocampus-dependent learning and memory, and hippocampal synaptic plasticity in THY-Tau22 transgenic mice, a murine tauopathy model that expresses double-mutated 4-repeat human tau, and shows neuropathological tau hyperphosphorylation and aggregation throughout the brain. Focussing on hippocampus, immunohistochemical studies in aged THY-Tau22 mice revealed prominent hyper- and abnormal phosphorylation of tau in CA1 region, and an increase in glial fibrillary acidic protein (GFAP) in hippocampus, but without signs of neuronal loss. These mice displayed spatial, social, and contextual learning and memory defects that could not be reduced to subtle neuromotor disability. The behavioral defects coincided with changes in hippocampal synaptic functioning and plasticity as measured in paired-pulse and novel long-term depression protocols. These results indicate that hippocampal tauopathy without neuronal cell loss can impair neural and behavioral plasticity, and further show that transgenic mice, such as the THY-Tau22 strain, might be useful for preclinical research on tauopathy pathogenesis and possible treatment.     

Can I retake it? Exploring subgroup differences and criterion-related validity in promotion retesting

Despite recent interest in the practice of allowing job applicants to retest, surprisingly little is known about how retesting affects 2 of the most critical factors on which staffing procedures are evaluated: subgroup differences and criterion-related validity. We examined these important issues in a sample of internal candidates who completed a job-knowledge test for a within-job promotion. This was a useful context for these questions because we had job-performance data on all candidates (N = 403), regardless of whether they passed or failed the promotion test (i.e., there was no direct range restriction). We found that retest effects varied by subgroup, such that females and younger candidates improved more upon retesting than did males and older candidates. There also was some evidence that Black candidates did not improve as much as did candidates from other racial groups. In addition, among candidates who retested, their retest scores were somewhat better predictors of subsequent job performance than were their initial test scores (rs = .38 vs. .27). The overall results suggest that retesting does not negatively affect criterion-related validity and may even enhance it. Furthermore, retesting may reduce the likelihood of adverse impact against some subgroups (e.g., female candidates) but increase the likelihood of adverse impact against other subgroups (e.g., older candidates).     

Risk and behavior: The mediating role of risk appraisal

The main issue of this paper concerns the mediating role of risk appraisal in the relation between past and future behavior. We expected previous risky behavior to heighten risk appraisal, which, in turn, should stimulate preventive behavior. Results ofthree tests of this mediation hypothesis showed that past behavior was strongly related to future behavior; people who behaved hazardously in the past indicated that they tend to do so in the future. Generally, the expected relation between past behavior and risk appraisal was supported. More risky behavior in the past was associated with a heightened risk appraisal. Results also indicate a relation between risk appraisal and future behavior, but in the opposite direction as predicted. Heightened risk appraisal was related to increased levels of risk in future behavior. When predicting future behavior by both risk appraisal and past behavior the effect of risk appraisal on future behavior disappeared, while past behavior remained a strong predictor of future behavior. In a few cases risk appraisal still predicted future behavior when past behavior was controlled for. Unfortunately, these cases showed the opposite relation; i.e., heightened risk appraisal was related to more risky future behavior. Implications of these findings for research on the role of risk appraisal will be discussed.