Aggressive disposition,alcohol, and aggression

This study investigated the effect of aggressive disposition on intoxicated and non-intoxicated aggressive behavior. Prior aggressiveness was measured with a structured questionnaire. Based on a bipartite split of scores, 28 subjects were assigned to the high aggressor group, and 29 to the low aggressor group. Subjects in both disposition groups were then randomly assigned to either a drunk or sober condition, and participated in a competitive reaction time task involving the administering and receiving of electric shocks to/from a fictitious opponent under conditions of high and low provocation. Aggression was defined as shock level intensity delivered to the sham opponent. When highly provoked, sober high aggressors were significantly more aggressive than low aggressors, thus validating the measure of aggressive disposition. When intoxicated, highly provoked individuals in both the high and low aggressive disposition groups attained equal levels of aggression. It was low aggressors who responded to escalated provocation with a significant increase in aggression responding when intoxicated. These results lend support to the notion that a pharmacological effect of alcohol can increase aggressive behaviour. Aggr. Behav. 23:11–18, 1997. © 1997 Wiley-Liss, Inc.     

Muscimol diffusion after intracerebral microinjections: a reevaluation based on electrophysiological and autoradiographic quantifications

Intracerebral muscimol injection is widely used to inactivate discrete brain structures during behavioral tasks. However, little effort has been made to quantify the extent of muscimol diffusion. The authors report here electrophysiological and autoradiographic results obtained after muscimol injection (1 microg/microl) either into the nucleus basalis magnocellularis (0.1-0.4 microl) or into the thalamic reticular nucleus (RE, 0.05-0.1 microl). In 52 rats, multiunit recordings were collected either in the RE or in the auditory thalamus during the 2 h following muscimol injection. Decreases in neuronal activity were observed up to 3 mm from the injection site; their time of occurrence was a function of the distance between the injection and recording sites. Because these decreases cannot be explained by physiological effects, they likely reflected muscimol diffusion up to the recording sites. Autoradiographic studies involved 25 rats and different experimental conditions. Optical density (OD) measures indicated that after a survival time of 15 min, a 0.05 microl injection produced a labeled area of 5.25 mm(2) at the injection site and a rostrocaudal labeling of 1.7 mm. Increasing the survival time to 60 min, or increasing the injected volume to 0.1 microl, systematically led to a larger labeled area at the injection site (8-12 mm(2)) and to a larger rostrocaudal diffusion (2.0-2.5 mm). Direct quantifications of radioactivity by a high-resolution radioimager validated the OD measures and even indicated a larger muscimol diffusion (up to 3.25 mm). Thus, these data point out that muscimol diffusion after intracerebral microinjection is larger than usually supposed. The relationships between these results and those obtained in behavioral studies are discussed.     

Infection markers and early signs of neonatal encephalopathy in the term infant

Recent evidence points to an association between intrauterine infection and cerebral palsy (CP) in the preterm as well as the term infant. The mechanisms that link these two conditions are unclear. Chorioamnionitis is a common clinical problem complicating 5-10% of pregnancies, whereas the incidence of CP attributed to intrapartum asphyxia is rare. Chorioamnionitis may result in brain injury as a result of interruption of placental blood flow (asphyxia), or via fever and/ or the cytokine release associated with infection. This review will attempt to establish the link between perinatal infection and brain damage in term infants. The characteristics of the perinatal inflammatory response, the potential mechanisms of brain injury associated with infection, and the clinical characteristics of neonatal encephalopathy will be discussed.     

The Greek ID Card Controversy: A Case Study of Religion and National Identity in a Changing European Union

This article presents the initial findings of a research project funded by the Leverhulme Trust from 2003 to 2005. It should be seen as the sequel to a pilot study originally conducted in 2002 and published in the Journal of Contemporary Religion in 2003 (Molokotos-Liederman, ”Identity Crisis“). The article examines the ID card controversy in Greece, setting it in its broader European context. Using data from newspaper articles and interviews, it maps the different opinion groups that emerge from this controversy and offers a preliminary analysis of these views. The final section indicates a range of topics that are emerging from this study and merit further investigation.     

Substance Abuse in Middle Eastern Adolescents Living in Two Different Countries: Spiritual,Cultural, Family and Personal Factors

It is estimated that the percentage of students using illicit substances by sixth grade has tripled over the last decade not only in developed countries but in developing countries as well probably due to the transition to a more Western society. Although much has been done to understand the mechanisms underlying substance abuse, few studies have been conducted with minority ethnic and religious groups such as Middle Eastern Youth. The primary goal of this study was to determine whether there are differences in factors contributing to substance abuse in adolescents from Lebanon versus the USA and to decipher the role of spirituality, religion, and culture among other factors that may influence substance abuse. A correlational cross-sectional design was used with adolescents living in two different countries: Los Angeles, California and Beirut, Lebanon. Muslim adolescents had significantly less rates of alcohol and substance use than Christians in both Lebanon and Los Angeles. More years lived in the USA increases the likelihood of abuse for both Muslims and Christians. Attachment to God and family was negatively associated with substance abuse. These results among others facilitate a better understanding of the influence of culture, religion, family and personal factors on substance abuse. Culturally sensitive interventions could benefit from the findings of this pilot study.     

Psychotherapy across languages: beliefs,attitudes and practices of monolingual and multilingual therapists with their multilingual patients

Aims: The present study investigates beliefs, attitudes and practices of 101 monolingual and multilingual therapists in their interactions with multilingual patients. Method: A mixed‐method approach was adopted using an online questionnaire with closed questions, and informed questions in interviews with one monolingual and two multilingual therapists. Results: A principal component analysis yielded a four‐factor solution accounting for 41% of the variance. The first dimension, which explained 17% of variance, reflects therapists' attunement towards their bilingual patients (attunement versus collusion). Further analysis showed that the 18 monolingual therapists differed significantly from their 83 bi‐ or multilingual peers on this dimension. The follow‐up interviews confirmed this result. Discussion: Recommendations based on these findings are made for psychotherapy training and supervision.     

Errors of Omission and Commission during Alternative Reinforcement of Compliance: The Effects of Varying Levels of Treatment Integrity

We conducted two experiments to evaluate the effects of errors of omission and commission during alternative reinforcement of compliance in young children. In Experiment 1, we evaluated errors of omission by examining two levels of integrity during alternative reinforcement (20 and 60 %) for child compliance following no treatment (baseline) versus treatment at full (i.e., 100 %) integrity. Results indicated that compliance varied according to the level of integrity in place. In addition, compliance in the 60 % integrity condition was high and stable when it followed baseline, but was substantially lower for one participant and slightly lower for a second participant when it followed the full integrity condition. In Experiment 2, we evaluated errors of commission. For three participants, we compared treatment at full integrity to a condition in which errors of commission were made on every trial (i.e., 0 % integrity). For one of these three participants, we also compared treatment at full integrity to baseline and to a condition in which errors of commission were made on 50 % of trials. Results of all four evaluations again indicate that compliance varied according to the level of integrity in place: compliance was low in both the 0 and 50 % integrity conditions, regardless of the preceding condition. These results suggest that during alternative reinforcement of compliance, the effect of occasional errors of omission may depend on the immediately preceding context but that errors of commission are more detrimental.     

A Developmental Psychopathology and Neurobiological Model of Borderline Personality Disorder in Adolescence

The antecedents and risk factors and for developing borderline personality disorder (BPD) are now well documented, but there is a paucity of developmental models to understand the key processes through which they impact on the development of BPD in adolescents. In this article, we present a developmental psychopathology model of BPD in adolescence and link the difficulties adolescents with BPD have with impulsivity and self regulation, with risk factors such as genetic vulnerability, parenting and trauma. We propose a number of psychological processes through which these risk factors undermine personal and interpersonal functioning, and makes it particularly difficult to engage with the challenges of adolescence. These key psychological processes undermine the integration of the self, with extreme unintegrated affects and extreme representations of self and others, undermining the capacity to mentalize. We then make links to possible neurobiological underpinnings of the disturbances in affect, Theory of Mind and interpersonal difficulties in adolescents with BPD.