Early development program: Collaborative structures and processes

The Early Development Program (EDP) provides and coordinates interdisciplinary mental health and developmental assessment/intervention for children ages zero through 3 years and their families. EDP's interdisciplinary team includes faculty in child and adolescent psychiatry, developmental pediatrics, pediatrics, psychology, developmental psychology, education, nursing, social service, speech and language, and occupational and physical therapy plus trainees in psychiatry, pediatrics, psychology, and education. Children are referred largely by pediatrics; two-thirds are insured by Medicaid and one-third by HMOs and private insurance. Local foundations help support ongoing assessment/intervention. Disruptive behavior is the most frequent referral problem; almost half of those presenting with disruptive behavior also have delays. Using the Diagnostic Classification: 0-3 (DC: 0-3), Disorders of affect, regulatory disorders, traumatic stress disorder, and relationship disorders are most often diagnosed; comorbid diagnoses are common. Family-centered intervention includes family-psychodynamic and interactional approaches and facilitated use and development of community resources. © 1997 Michigan Association for Infant Mental Health     

Breast cancer: The intention to have a mammography and a clinical breast examination - application of the theory of planned behavior

Abstract

The purpose of these cross sectional studies was to identify the psychosocial factors explaining women's intention to have a mammography within the next two years and their intention to have a clinical breast examination (CBE) by a professional within the next year. Two random samples of women aged 40–69 years (n_a = 354, n_b = 344) completed a self-administered questionnaire that investigated theoretical constructs of the theory of planned behavior. The results of structural equation modeling showed that subjective norms and perceived behavioral control explained 81 % of the variance in intention of having a mammography. Sixty-five percent (65%) of the variance in intention of having a CBE was explained by attitude and perceived behavioral control. In conclusion, women need to be better informed, have better skills to overcome psychological and physical barriers in performing preventive breast behaviors, and promotion of preventive breast cancer methods should consider people significant for women.     

The effects of stress on dna repair capacity

Abstract

Research has shown that lymphocytes of high-distress patients have reduced DNA repair relative to that of low-distress patients and healthy controls. Furthermore, deficits in repair are associated with an increased risk of cancer. Using and academic stress model, we hypothesized that students would exhibit lower levels of Nucleotide Excision Repair (NER) during a stressful exam period when compared to a lower stress period. Participants were 19 healthy graduate level students. NER was measured in lymphocytes using the unscheduled DNA synthesis (UDS) assay with slide autoradiography. Contrary to prediction, mean values for NER significantly increased during the higher stress period relative to the lower stress period controlling for background differences in repair. Furthermore, lymphocytes had significantly increased repair of endogenous damage during the higher stress period. Stress appears to directly increase DNA repair. Additionally, stress may increase DNA repair indirectly by increasing damage to DNA.     

The roles of dispositional optimism and pessimism in hiv disease progression

Relationships between dispositional optimism and pessimism and the course of HIV infection, determined by changes in viral load and CD4 counts, were studied in a longitudinal cohort of 412 patients on antiretroviral therapy (ART). Multiple regression analyses controlling for baseline levels of disease status, ethnicity, and depressive symptoms demonstrated that higher pessimism at baseline was associated with higher viral load at follow-up (average of 18 months later). Optimism at baseline had a curvilinear relationship with CD4 counts at follow-up. Moderate levels of optimism at baseline predicted the highest CD4 counts at follow-up. Although optimism and pessimism were associated with specific health behaviors (e.g., ART adherence, cigarette use, drug use, dietary practices), none of these behaviors mediated the optimism/pessimism effects. The biologic and behavioral mediators of associations of personality variables with the course of treated HIV infection deserve continued investigation.