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121.
Giedd JN Stockman M Weddle C Liverpool M Alexander-Bloch A Wallace GL Lee NR Lalonde F Lenroot RK 《Neuropsychology review》2010,20(4):349-361
Magnetic resonance imaging studies have begun to map effects of genetic variation on trajectories of brain development. Longitudinal studies of children and adolescents demonstrate a general pattern of childhood peaks of gray matter followed by adolescent declines, functional and structural increases in connectivity and integrative processing, and a changing balance between limbic/subcortical and frontal lobe functions, which extends well into young adulthood. Twin studies have demonstrated that genetic factors are responsible for a significant amount of variation in pediatric brain morphometry. Longitudinal studies have shown specific genetic polymorphisms affect rates of cortical changes associated with maturation. Although over-interpretation and premature application of neuroimaging findings for diagnostic purposes remains a risk, converging data from multiple imaging modalities is beginning to elucidate the influences of genetic factors on brain development and implications of maturational changes for cognition, emotion, and behavior. 相似文献
122.
Johnson AW Han S Blouin AM Saini J Worley PF During MJ Holland PC Baraban JM Reti IM 《Learning & memory (Cold Spring Harbor, N.Y.)》2010,17(12):620-626
Neuronal activity regulated pentraxin (Narp) is a secreted protein that regulates α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors (AMPAR) aggregation and synaptogenesis. Mapping of Narp-positive neurons in brain has revealed it is prominently expressed in several limbic system projection pathways. Consistent with this localization pattern, Narp knockout mice show deficits in using the current value of a reinforcer to guide behavior, a critical function of the limbic system. To help assess whether this behavioral deficit is due to impairment of synaptogenesis during development or in modulating synaptic signaling in the mature brain, we have used a dominant negative Narp viral construct which blocks trafficking of endogenous Narp to axons. Focal injection of this viral construct into the medial prefrontal cortex (mPFC) of adult mice, a region containing Narp-positive projection neurons, blocked reinforcer devaluation. Thus, these results indicate that Narp released from mPFC neurons plays a key role in mediating synaptic changes underlying instrumental reinforcer devaluation. 相似文献
123.
Location-based cuing experiments have shown that inhibition of return (IOR) spreads beyond a cued location but appears to
be confined to the cued hemifield by the vertical meridian. Previous studies have also shown that IOR can spread across objects
and here we investigate whether an object can be used to mediate the spreading of IOR into the opposite hemifield. Two experiments
used a rectangular object that surrounded four target locations, two to the left and right of a central fixation point. The
spreading of IOR in the presence of the object was determined and compared with a condition where the object-frame was absent.
Object-present and object-absent trials were either mixed within a block (Experiment 1) or divided into separate blocks (Experiment
2). Both experiments revealed robust inhibition in the cued but not the uncued hemifield, further demonstrating the hemifield-based
spreading of IOR. 相似文献
124.
When non-informative peripheral cues precede a target defined by a specific feature, cues that share the critical feature will capture attention while cues that do not will be effectively ignored. We tested whether different attentional control sets can be simultaneously maintained over distinct regions of space. Participants were instructed to respond only to specific colored targets at specific locations. Most trials included non-predictive cues whose location and/or color were either congruent or incongruent with the spatial and/or color properties of the impending target. We observed contingent capture only for cues that were consistent with the attentional control set applied to that region of space. This is the first demonstration that separate attentional control sets can be simultaneously maintained at distinct spatial locations, with implications for the flexibility of endogenous control over automatic attentional orienting. 相似文献
125.
A primary criterion on which models of cognition are evaluated is their ability to fit empirical data. To understand the reason why a model yields a good or poor fit, it is necessary to determine the data-fitting potential (i.e., flexibility) of the model. In the first part of this article, methods for comparing models and studying their flexibility are reviewed, with a focus on parameter space partitioning (PSP), a general-purpose method for analyzing and comparing all classes of cognitive models. PSP is then demonstrated in the second part of the article in which two connectionist models of speech perception (TRACE and ARTphone) are compared to learn how design differences affect model flexibility. 相似文献
126.
Dissociation is typically defined as the lack of normal integration of thoughts, feelings, and experiences into consciousness and memory. The present article critically evaluates the research literature on cognitive processes in dissociation. The authors' review indicates that dissociation is characterized by subtle deficits in neuropsychological performance (e.g., heightened distractibility). Some of the cognitive phenomena (e.g., weakened cognitive inhibition) associated with dissociation appear to be dependent on the emotional or attentional context. Contrary to a widespread assumption in the clinical literature, dissociation does not appear to be related to avoidant information processing. Rather, it is associated with an enhanced propensity toward pseudo-memories, possibly mediated by heightened levels of interrogative suggestibility, fantasy proneness, and cognitive failures. Evidence for a link between dissociation and either memory fragmentation or early trauma based on objective measures is conspicuously lacking. The authors identify a variety of methodological issues and discrepancies that make it difficult to articulate a comprehensive framework for cognitive mechanisms in dissociation. The authors conclude with a discussion of research domains (e.g., sleep-related experiences, drug-related dissociation) that promise to advance our understanding of cognition and dissociation. 相似文献
127.
Lamond N Jay SM Dorrian J Ferguson SA Roach GD Dawson D 《Behavior research methods》2008,40(1):347-352
In this study, we evaluated the sensitivity of a 5-min personal digital assistant-psychomotor vigilance test (PDA-PVT) to severe sleep loss. Twenty-one participants completed a 10-min PVT-192 and a 5-min PDA-PVT at two hourly intervals during 62 h of sustained wakefulness. For both tasks, response speed and number of lapses (RTs > 500) per minute significantly increased with increasing hours of wakefulness. Overall, standardized response speed scores on the 5-min PDA-PVT closely tracked those of the PVT-192; however, the PDA-PVT was generally associated with more lapses/minute. Closer inspection of the data indicated that when the level of sleep loss and fatigue became more severe (i.e., Day 3), the 5-min PDA-PVT was not quite as sensitive as the 10-min PVT-192 when 2- to 10-sec foreperiods were used for both. It is likely, however, that the observed differences between the two devices was due to differences in task length. Thus, the findings provide further evidence of the validity of the 5-min PDA-PVT as a substitute for the 10-min PVT-192, particularly in circumstances in which a shorter test is required and/or the PVT-192 is not as practical. 相似文献
128.
Jay L. Garfield 《Sophia》2006,45(2):61-80
This question—why did Bodhidharma come from the West?— is ubiquitous in Chinese Ch’an Buddhist literature. Though some see it as an arbitrary question intended merely as an opener to obscure puzzles, I think it represents a genuine intellectual puzzle: Why did Bodhidharma come from theWest—that is, fromIndia? Why couldn’tChina with its rich literary and philosophical tradition have given rise to Buddhism? We will approach that question, but I prefer to do so backwards. I want to ask instead, “why was it so fortuitous for the development of Buddhist philosophy that Bodhidharma wentEast? I will argue that by doing so he gave a trajectory to Buddhist thought about the mind and knowledge that allows certain issues that are obscure in Indo-Tibetan Buddhism, despite their centrality to the Buddhist critique of Indian orthodoxy, to come into sharper relief, and hence to complete a project begun, but not completable, in that Indo-European context. 相似文献
129.
Jay Rosenberg 《Topoi》2006,25(1-2):97-99
Culturally, America is well overdue for a Second Enlightenment, but since the dominant majority of its citizens are regrettably
both symbol-minded and star-craving mad, and since the mass media are generally inaccessible to us, the chance that contemporary
philosophers could contribute to such a thing, much less help instigate it, is near vanishingly small. As educators, in contrast,
we can perhaps make ourselves useful by beginning to clear the extensive muck out of at least some of our students’ minds.
In any event, the discipline of philosophy as such is in serious need of renewal, but that, should it unexpectedly happen,
will be matter of luck rather than a result of deliberate action. 相似文献
130.
This research assessed factors that may affect men’s romantic relationships. One hundred men (50 heterosexual and 50 gay) in the Northeast US completed measures that assessed masculinity ideology, male identity, and relationship quality. We examined whether the quality of heterosexual men’s romantic relationships differ from that of romantic relationships among gay men, and whether masculinity ideology and male identity are related to the quality of heterosexual and same-sex romantic relationships. Results indicated no differences between heterosexual and gay men in the perceived quality of romantic relationships. However, in both gay and heterosexual men, traditional masculinity ideology and a male identity characterized by a lack of psychological relatedness to other men were associated with lower quality romantic relationships. 相似文献