Making Common Sense of Vaccines: An Example of Discussing the Recombinant Attenuated Salmonella Vaccine with the Public

Researchers have iterated that the future of synthetic biology and biotechnology lies in novel consumer applications of crossing biology with engineering. However, if the new biology’s future is to be sustainable, early and serious efforts must be made towards social sustainability. Therefore, the crux of new applications of synthetic biology and biotechnology is public understanding and acceptance. The RASVaccine is a novel recombinant design not found in nature that re-engineers a common bacteria (Salmonella) to produce a strong immune response in humans. Synthesis of the RASVaccine has the potential to improve public health as an inexpensive, non-injectable product. But how can scientists move forward to create a dialogue of creating a ‘common sense’ of this new technology in order to promote social sustainability? This paper delves into public issues raised around these novel technologies and uses the RASVaccine as an example of meeting the public with a common sense of its possibilities and limitations.     

Heurísticos en la representación del conocimiento: Estrategias de clasificación de categorías difusas y bien definidas

Resumen

La hipótesis que establece que el sistema ajusta sus descripáones a una transformación lineal de las propiedades que resultan del análisis perceptivo no está justificada y es evidente que la formación de categorías o conceptos es posible, aun tratando con categorías que no aceptan un modelo monotónico de representación. En esta investigación se analizan en dos experimentos las estrategias que permiten describir un cierto dominio de conocimiento en términos de un sistema binario de categorías difusas o bien definidas. Las descripciones que los sujetos efectúan suponen la formación de un sistema no monotónico de reglas de inferencia que permite distribuir los estímulos en clases complementarias, según contribuyan al proceso de decisión. Esta distribución no lineal de los estímulos en términos de las alternativas de respuesta es la que determina frente a los modelos de categorización propuestos hasta la fecha del proceso de categorización.     

Mentalizing in psychotherapy: patients’ and therapists’ reflective functioning during the psychotherapeutic process / Mentalizando en psicoterapia: funcionamiento reflexivo de pacientes y terapeutas durante el proceso psicoterapéutico

Abstract

There has been a growing interest in mentalization in clinical research given its relationship with normal and psychopathological functioning and its explanatory potential as a mechanism of psychotherapeutic change. This study uses the Reflective Functioning Scale (RFS) to identify and characterize mentalization manifestations in psychotherapeutic interaction. Method: the RFS was applied to a sample of relevant episodes — 44 sessions from five different psychotherapy processes carried out with adult patients who had different diagnoses. Results: we observed a higher probability of reflective functioning (RF) passages in relevant events than in neutral segments. There were no differences in the RF passages according to episode or actor type, but there were in RF Failures, which is more likely in patients and during rupture episodes. Discussion: although certain modifications are necessary, the RFS can be applied to clinical material, and it is a promising strategy for the study of mentalization within psychotherapy.     

Indicatives at stake

Several authors have claimed that indicative conditionals are sensitive to the epistemic perspective of agents. According to this sort of view, the truth of an indicative conditional depends on the background evidence of some relevant agent or group of agents. In this paper, I argue that the context-dependence of indicative conditionals goes beyond this. Indicative conditionals are not only sensitive to the evidence of agents, but also to contextual factors that determine what is inferable from such background evidence (plus the antecedent of the conditional). More specifically, my proposal is that when the inference associated with a conditional is defeasible, the truth of that conditional is sensitive to practical stakes (in a similar way that knowledge claims are sensitive to practical stakes).     

Developmental changes in decision making under risk: The role of executive functions and reasoning abilities in 8- to 19-year-old decision makers

Previous studies have shown that children and adolescents often tend toward risky decisions despite explicit knowledge about the potential negative consequences. This phenomenon has been suggested to be associated with the immaturity of brain areas involved in cognitive control functions. Particularly, “frontal lobe functions,” such as executive functions and reasoning, mature until young adulthood and are thought to be involved in age-related changes in decision making under explicit risk conditions. We investigated 112 participants, aged 8–19 years, with a frequently used task assessing decisions under risk, the Game of Dice Task (GDT). Additionally, we administered the Modified Card Sorting Test assessing executive functioning (categorization, cognitive flexibility, and strategy maintenance) as well as the Ravens Progressive Matrices assessing reasoning. The results showed that risk taking in the GDT decreased with increasing age and this effect was not moderated by reasoning but by executive functions: Particularly, young persons with weak executive functioning showed very risky decision making. Thus, the individual maturation of executive functions, associated with areas in the prefrontal cortex, seems to be an important factor in young peoples’ behavior in risky decision-making situations.     

Effects of providing advance cues during a soccer penalty kick on the kicker's rate of success

The effect of explicitly providing goalkeeper's movement advanced cue to the kicker during a real penalty kick task was assessed. 32 expert soccer players (M age= 23.2 yr.), who were divided into four groups: an experimental group, a discovery group, a placebo group, and a control group, participated. Rate of success in the task was assessed, as well as goals, decision times, and ball flight times. Providing an advance cue significantly improved the players' rate of success relative to players without the advance cue; this difference was still present after 1 and 7 days without training. The experimental group adapted better to the time range within which the response could be effective, while the discovery group showed adaptations. Explicit instructions about the advance cues available from goalkeepers' actions before the dive during practice can improve penalty kick performance.     

Psychological care demand in clinical practice: treatment and results

With the aim of describing the usual clinical context as opposed to the academic or research context, the characteristics of patients and psychological treatments applied in a sample of 856 patients from the Clinic of Psychology of the Complutense University is analyzed. The disorders that require attention, the characteristics of the therapists and their interventions are identified. Out of the total patients, 24.3% withdrew from treatment; 68.3% of the patients who started treatment completed it with therapeutic success. 83% of patients were assessed in 4 sessions or fewer (median=4). 75.3% of patients who finished the treatment received 18 or fewer treatment sessions (median=11). The generalization of the results and their implications for professional clinical practice and for training clinical psychologists are discussed.     

Incidence of anovulatory menstrual cycles among dysmenorrheic and non-non-dysmenorrheic [corrected] women: effects on symptomatology and mood

The incidence of spontaneous anovulatory (SA) menstrual cycles among dysmenorrheic and non-dysmenorrheic women and their effects on symptomatology and mood were examined in 52 university students distributed into two groups (18 dysmenorrheic women and 34 non-dysmenorrheic women) according to the presence or absence of symptoms of primary dysmenorrhea. Women were tested in menstrual, ovulatory and premenstrual phases. In order to estimate the proportion of ovulatory and SA cycles the basal body temperature (BBT) method was used. Results indicated that the percentage of SA cycles found in dysmenorrheic women does not confirm that primary dysmenorrhea only occurs in ovulatory cycles. In addition, the ovulatory cycles did not present greater symptomatology than the anovulatory cycles in self-rating of negative affect. In fact, menstrual symptomatology was not associated with ovulatory cycles. These data confirm that primary dysmenorrhea does not only depend on the endocrine factors which regulate the menstrual cycle but also on other factors such as social or psychological ones.     

Efficacy of a group memory training method for older adults based on visualization and association techniques: A randomized,controlled trial with a placebo group

The aim of this trial has been to determine the efficacy of a group memory training method. The experimental group was compared to a placebo group (health education) or to a control group (waiting list). Forty‐five adults between the ages of 60 and 70 years (M = 66.9) were recruited by placing notices in senior citizen community centres, which encouraged people with memory problems to participate in the study. Data were collected at baseline, 1 week, and 6 months after the intervention. The efficacy of the training was evaluated by measures of objective and subjective everyday memory performance. After intervention, the experimental group participants showed an increase in objective memory performance (d = 1.95). The effect size was even higher at 6 months after intervention (d = 2.88). Further, their subjective experience related to everyday memory slips decreased (d = ?0.52). The memory training method was effective in improving everyday memory in older people with some cognitive decline. Copyright © 2009 John Wiley & Sons, Ltd.     

Group and individual change in the treatment of drug addictions: a follow-up study in therapeutic communities

The pre-post treatment change of 112 patients in two therapeutics Spanish communities is described. The Addiction Severity Index (ASI) was used at intake and at the end of the treatment program. Results of the treatment program were evaluated by applying composite scores (CS) of the ASI, and the evolution of each patient was evaluated using the Reliable Change Index (RCI). 69.7% of the sample completed treatment, and 30.3% dropped out prematurely. At intake, the percentage of people who could improve in the different areas of the ASI ranged between 35.1% for alcohol consumption and 95.3% for family relationships. At the follow-up, the percentage of subjects who showed significant statistical improvements in the different areas varied between 7.9% in family relations and 66.7% in alcohol consumption. The percentage of patients who deteriorated was less than 10% for all variables. Implications for further research and clinical practice are commented upon.