Offering predictive testing for Huntington disease in a medical genetics clinic: Practical applications

Predictive testing for Huntington disease is presently offered in a select few medical genetics centers in the United States. This is in part due to the labor intensive counseling and psychological testing suggested by the research protocols. We discuss some specific suggestions for establishing programs for Huntington disease predictive testing within pre-existing medical genetics clinics to encourage more centers to offer presymptomatic testing. This will allow more at risk individuals the opportunity to consider predictive testing and cut down the expenses of traveling to the few predictive testing centers that currently exist. The counseling principals will remain similar to those discussed here, even following the identification of the Huntington disease mutation.     

Punished and Nonpunished Responding in A Multiple Schedule in Humans: A Brief Report

Four male subjects responded on a multiple schedule in which responding was maintained by a random interval 20-sec (RI20) schedule of point presentation. Responding was suppressed in alternating components by an added variable ratio 30 (VR30) schedule of point subtractions. Each component was accompanied by distinctive stimulus lights. Subjects were exposed to the multiple schedule from the initial session. Two subjects experienced four 50-min sessions daily (Experiment 1) and the other two subjects participated in one 50-min session daily (Experiment 2). Once responding in the punished components had stabilized, responding in the nonpunished components continued to increase across sessions. Nonpunished responding did not stabilize even after as many as 36 sessions. These results are discussed in the context of previous studies using animals which employed multiple schedules with punished and nonpunished response contingencies.

     

Sources of difficulty in deductive reasoning: The THOG task

The THOG task presents four designs constructed from two shapes and two colours. Subjects are told that the experimenter has written down one of the shapes and one of the colours and are provided the rule that if, and only if, any design has either the shape or the colour, but not both, written down, then it is a THOG. Finally, they are given an exemplar and are asked to classify the remaining designs. Successful solution requires construction of hypotheses, reasoning under each hypothesis, and comparison of the results under each to reach a final conclusion. Few subjects are able to provide adequate responses on the standard version of the task. We present the results of four experiments, with 160 undergraduates each presented with one of eight versions of the task. Experiments 1 and 2 indicate that (1) some subjects think that the properties that are written down are identical to those of the exemplar, although these are not the same subjects who exhibit the modal error pattern, (2) many subjects correctly understand the disjunction of the rule but fail to consider the hypotheses, and (3) poor initial encoding of the problem is not easily corrected. Experiment 3 investigates the sufficiency of the claim of Griggs and Newstead (1982) that appropriate problem solution follows from explicit presentation of all problem information (including use of positive labels for properties that are not written down), and Experiment 4 investigates the necessity of the claim. The results of Experiments 3 and 4 show that presenting positive category labels does increase the frequency of correct solution; however, positive category labels are not necessary for such improvement. Separation of the labels of the THOG rule from those of the exemplar, or informing subjects that only one other design is a THOG, also increases the frequency of successful solution. The results suggest that many people have some fairly sophisticated reasoning skills. but application of these skills is easily discouraged when the features of the task lead to poor initial encoding.     

An MMPI-based empirical model of malingering and deception

The empirically-based model of malingering and deception described by Rogers (1984b) was operationalized using MMPI and clinical interview data. Subjects (N = 159) were patients committed to an inpatient forensic hospital as ‘Incompetent to Stand Trial’ or ‘Not Guilty by Reason of Insanity’. Inter-rater reliability was acceptable for the 11 criteria used to define response styles. Each subject was categorized into one of five response style groups: ‘Reliable’, ‘Malingering’, ‘Defensive’, ‘Irrelevant’, or ‘Unclassifiable’. Factor analysis of the rating criteria yielded four factors, three of which are comparable to the assigned groups, providing some validation for the constructs underlying these groups.     

Physique Contrast Effect: Adverse Impact of Idealized Body Images for Women

Adherence to an attractiveness ideal was considered as a possible mediator of a physique contrast effect among Caucasian women. Following exposure to photographs of models typifying idealized thin physiques, women displayed decreased self-esteem and increased self-consciousness, social physique anxiety, and body dissatisfaction. Although women with low adherence to an attractiveness ideal seemed to be advantaged by having greater self-esteem, less self-consciousness, and lower physique anxiety or dissatisfaction than their high adherence counterparts, these women did not display any unique resistance to the contrast effect. High affirmation of an attractiveness ideal was associated with exceptionally high potential for disordered eating. Eating disorder potential did not show influence of the contrast effect, but long-term implications were considered.     

GLOBAL PROCESSING OF BIOLOGICAL MOTIONS

Abstract— The structure of the human form is quickly and unequivocably recognized from 10 to 13 points of light moving as if attached to the major joints and head of a person walking Recent psychophysical and computational models of this process suggest that these displays are organized by low-level processing constraints that delimit the pair-wise connections of the point lights In the current research, these low-level constraints were rendered uninformative by a masking paradigm The results from four experiments converged to show that the perception of structure in a point-light walker display does not require the prior detection of individual features or local relations