关注降压药物的选择，促使更有效的降压达标

我国成人高血压患病率高达18.8%,全国有高血压患者约1.6亿。合理的药物治疗是降压达标的主要措施,如何进行正确选择成为摆在我们面前的难题。目前,降压药物主要包括利尿剂、β受体阻断剂、血管紧张素转换酶抑制剂、血管紧张素Ⅱ受体拮抗剂、钙拮抗剂和α受体阻断剂6类。因降压治疗的收益主要来自于降压本身,为了提高降压达标率及高血压患者的用药依从性,目前多主张低剂量联合治疗。     

超越心理健康：精神健康的追求

区别于一般心理概念的、狭义的精神概念有三个特征:终极关怀、内发自生以及自由意志。诸如精神信仰危机、生活目标迷茫等区别于传统心理问题的精神问题已经成为现代人的顽疾。现代心理健康标准开始关注并尝试吸纳精神健康。精神健康是21世纪的健康主题,现代人不应仅仅满足于生理和心理的健康,还应寻求更高层次的精神健康。     

Alcohol: Effects on Neurobehavioral Functions and the Brain

Alcoholism results from an interplay between genetic and environmental factors, and is linked to brain defects and associated cognitive, emotional, and behavioral impairments. A confluence of findings from neuroimaging, physiological, neuropathological, and neuropsychological studies of alcoholics indicate that the frontal lobes, limbic system, and cerebellum are particularly vulnerable to damage and dysfunction. An integrative approach employing a variety of neuroscientific technologies is essential for recognizing the interconnectivity of the different functional systems affected by alcoholism. In that way, relevant experimental techniques can be applied to assist in determining the degree to which abstinence and treatment contribute to the reversal of atrophy and dysfunction.     

Traumatic memories of war veterans: not so special after all

Several authors have argued that traumatic experiences are processed and remembered in a qualitatively different way from neutral events. To investigate this issue, we interviewed 121 Croatian war veterans diagnosed with posttraumatic stress disorder (PTSD) about amnesia, intrusions (i.e., flashbacks and nightmares), and the sensory qualities of their most horrific war memories. Additionally, they completed a self-report scale measuring dissociative experiences. In contrast to what one would expect on the basis of theories emphasizing the special status of traumatic memories, amnesia, and high frequency intrusions were not particularly typical for our sample of traumatized individuals. Moreover, traumatic memories were not qualitatively different from neutral memories with respect to their stability and sensory qualities. The severity of PTSD symptoms was not significantly correlated with dissociative experiences. Our findings do not support the existence of special memory mechanisms that are unique to experiencing traumatic events.     

The perception of subjective contours and neon color spreading figures in young infants

The goal of the present habituation—dishabituation study was to explore sensitivity to subjective contours and neon color spreading patterns in infants. The first experiment was a replication of earlier investigations that showed evidence that even young infants are capable of perceiving subjective contours. Participants 4 months of age were habituated to a subjective Kanizsa square and were tested afterward for their ability to differentiate between the subjective square and a nonsubjective pattern that was constructed by rotating some of the inducing elements. Data analysis indicated a significant preference for the nonsubjective pattern. A control condition ensured that this result was not generated by the difference in figural symmetry or by the local differences between the test displays. In the second experiment, infant perception of a neon color spreading display was analyzed. Again, 4-month-old infants could discriminate between the illusory figure and a nonillusory pattern. Furthermore, infants in a control group did not respond to the difference in symmetry and the local differences between two nonillusory targets. Overall, the results show that young infants respond to illusory figures that are generated by either implicit T-junctions (Experiment 1) or implicit X-junctions (Experiment 2). The findings are interpreted against the background of the neurophysiological model proposed by Grossberg and Mingolla (1985).     

利多卡因凝胶在手术室麻醉诱导后留置尿管中的应用

分析手术室麻醉诱导后留置尿管产生尿路疼痛等不良反应的原因,探讨利多卡因凝胶在克服上述反应方面的作用及其他预防措施。采用方便取样将70例留置尿管的患者分为试验组和对照组,麻醉诱导后试验组在尿管上涂抹利多卡因凝胶（0．5ml／cm）后再按常规操作插管;对照组以石蜡油为润滑剂按常规操作留置尿管。比较两组患者心率、血压情况及躁动、疼痛评分。结果提示麻醉诱导后留置尿管可以有效减轻患者清醒状态下置管引起的尿路疼痛等问题,但不能避免患者苏醒期出现上述反应;使用利多卡因凝胶可有效预防患者苏醒期出现的尿路疼痛及其它不良反应,增加患者的舒适度。     

Specialization effect and its influence on memory and problem solving in expert chess players

Expert chess players, specialized in different openings, recalled positions and solved problems within and outside their area of specialization. While their general expertise was at a similar level, players performed better with stimuli from their area of specialization. The effect of specialization on both recall and problem solving was strong enough to override general expertise—players remembering positions and solving problems from their area of specialization performed at around the level of players 1 standard deviation (SD) above them in general skill. Their problem-solving strategy also changed depending on whether the problem was within their area of specialization. When it was, they searched more in depth and less in breadth; with problems outside their area of specialization, the reverse. The knowledge that comes from familiarity with a problem area is more important than general purpose strategies in determining how an expert will tackle it. These results demonstrate the link in experts between problem solving and memory of specific experiences and indicate that the search for context-independent general purpose problem-solving strategies to teach to future experts is unlikely to be successful.     

Age‐related changes in transient and oscillatory brain responses to auditory stimulation during early adolescence

Maturational changes in the capacity to process quickly the temporal envelope of sound have been linked to language abilities in typically developing individuals. As part of a longitudinal study of brain maturation and cognitive development during adolescence, we employed dense‐array EEG and spatiotemporal source analysis to characterize maturational changes in the timing of brain responses to temporal variations in sound. We found significant changes in the brain responses compared longitudinally at two time points in early adolescence, namely 10 years (65 subjects) and 11.5 years (60 of the 65 subjects), as well as large differences between adults, studied with the same protocol ( Poulsen, Picton & Paus, 2007 ), and the children at 10 and 11.5 years of age. The transient auditory evoked potential to tone onset showed decreases in the latency of vertex and T‐complex components, and a highly significant increase in the amplitude of the N1 wave with increasing age. The auditory steady state response to a 40‐Hz frequency‐modulated tone increased in amplitude with increasing age. The peak frequency of the envelope‐following response to sweeps of amplitude‐modulated white noise also increased significantly with increasing age. These results indicate persistent maturation of the cortical mechanisms for auditory processing from childhood into middle adulthood.     

Becoming human,becoming sober

Two themes run through Kierkegaard’s authorship. The first defines existential requirements for “becoming human”—reflective honesty and earnest humor. The second demarcates the religious phenomena of sobriety when human becoming suffers insurmountable collisions. Living with existential pathos teaches the difference between the either/or logic of collisions and the both/and logic of development and transitions. There is a difference between self-transformation and a progressive individual and social development. In the developmental mode self experiences gradual progression or adaptive evolution; in the self-transformative mode self undergoes qualitative upsurges, leaps, gestalt switches, musical key transpositions of becoming in individual and social evolutions. Each individual in every epoch begins at the beginning. The author traces the movements of becoming in their parallel dimensions, drawing a fork through Kierkegaard’s writing. The first leads through the existence spheres of his pseudonymous authorship. The second intensifies the movement on the spot and in the moment.