Posttraining activation of CB1 cannabinoid receptors in the CA1 region of the dorsal hippocampus impairs object recognition long-term memory

Evidence indicates that brain endocannabinoids are involved in memory processing. However, the participation of CB1 and CB2 cannabinoid receptors in recognition memory has not been yet conclusively determined. Therefore, we evaluated the effect of the posttraining activation of hippocampal cannabinoid receptors on the consolidation of object recognition memory. Rats with infusion cannulae stereotaxically aimed to the CA1 region of the dorsal hippocampus were trained in an object recognition learning task involving exposure to two different stimulus objects. Memory retention was assessed at different times after training. In the test sessions, one of the objects presented during training was replaced by a novel one. When infused in the CA1 region immediately after training, the non-selective cannabinoid receptor agonist WIN-55,212-2 and the endocannabinoid membrane transporter inhibitor VDM-11 blocked long-term memory retention in a dose-dependent manner without affecting short-term memory, exploratory behavior, anxiety state or the functionality of the hippocampus. The amnesic effect of WIN-55,212-2 and VDM-11 was not due to state-dependency and was completely reversed by co-infusion of the CB1 receptor antagonist AM-251 and mimicked by the CB1 receptor agonist ACEA but not by the CB2 receptor agonists JWH-015 and palmitoylethanolamide. Our data indicate that activation of hippocampal CB1 receptors early after training hampers consolidation of object recognition memory.     

Evaluating the quality and impact of mediators for learning when using associative memory strategies

Recently, a series of studies has reported much greater recall for factual information when students were asked to generate elaborations in response to ‘why’ questions (elaborative interrogation) relative to studying provided elaborations. The two experiments reported here extend and clarify research regarding the strategic benefits of generating elaborations versus providing elaborations. In both experiments, undergraduates studied 30 sentences, all of which described one particular man doing one activity. Students used one of three study strategies. In two conditions, students studied provided elaborations (PE). Half of the elaborations explained why the particular man engaged in the particular activity and half did not explain the specific relations. In the remaining condition, students generated their own elaborations. In both experiments, students were provided with their generated/provided elaborations as cues for recalling the fact at testing. When students were not explicitly cued to use the generated/ provided elaboration at recall, elaborative interrogation (EI) consistently outperformed the PE condition. Recall in the EI condition did not exceed recall in the PE condition, however, when students were provided with good explanatory elaborations and were cued with them at testing. These experiments demonstrate that the poorer performance associated with providing relative to generating elaborations can be mediated by encouraging more meaningful processing of materials and prompting students to access their mediators at recall.     

CONTRIBUTION A UNE ETUDE COMPARATIVE DES GARCONS ET DES FILLES EN FRANCE*

The sample of subjects and the modifications to the general research design due to local pecularities are described. From the analyses on the four questionnaires emerges an effect of sex on the following variables: Desired Number of Children (F> M), Masculinity (M > F), Femininity (M < F), Willing to compote (M > F) and five professional values from the fifteen. There is also an effect of the technical versus college samples on Educational Aspirations and Expectations, on Masculinity for self (but only for the older subjects) and on seven professional values. Positive correlations are obtained (for males and females, separately) between age, on the one hand, and Educational Aspirations, Educational Expectations, and the valorisation of Variety, on the other hand. The relationships between age, on the one hand, and Competition and Prestige, on the other hand, decrease as a function of age. For males, the value of Work decreases with age. For females, Masculinity as well as Work Security both decrease with age while the values of Independency and Creativity increase. Although the correlational analyses suggest some differences between males and females, the strongest correlations are common to both sexes. A preliminary study has been carried out on the effect of social environment.     

Distance-Delivered Parent Training for Childhood Disruptive Behavior (Strongest Families™): a Randomized Controlled Trial and Economic Analysis

Disruptive behavior disorders are prevalent in youth, yet most children with disruptive behavior do not have access to timely, effective treatment. Distance-delivered service (e.g., via telephone, Internet) can overcome several barriers to care. This study tested the effectiveness of a 12-week parent training program, Strongest Families? Parenting the Active Child, delivered via written material, skill-based videos, and telephone coaching sessions, as compared to usual care in reducing child externalizing behavior. Participants were 172 primary caregivers of a 6- to 12-year-old (29% girls; M age?=?8.5 years) recruited from community children’s mental health clinics. Participants were randomized to either Strongest Families? or usual care and completed measures of child externalizing behavior, parenting practices, parent distress, and intervention services consumed at baseline and 5-, 10-, 16-, and 22-months post-baseline. Growth curve analysis showed significant reductions in externalizing behavior in both conditions over time. Improvements were significantly greater at 10 months in the Strongest Families? condition (d =?0.43). At 22 months, however, the differences were not significant and small in magnitude (d =??0.05). The intervention decreased inconsistent discipline significantly more than usual care. Parents in both conditions showed significant reductions in distress. We also conducted a cost-effectiveness analysis to assess the value for money of the Strongest Families? program versus usual care. Distance parent training is a promising way to increase access to, and reduce costs associated with, mental health care for families with a child with disruptive behavior.     

Private Terrors Sexualized Aggression and a Psychoanalyst's Fear of Her Patient

This clinical paper explores the meanings and evolution of an analyst's reaction of fear in relation to her patient's sexualized aggression. From both an intrapsychic and an intersubjective perspective, the author analyzes the coconstruction of this transference—countertransference phenomenon. Case vignettes illustrate the author's attempts to address her patient's sexualized aggression while struggling to free herself from the feelings of intimidation and fearfulness stirred by his sadomasochistic fantasies and patterns of interaction. The analyst's unconscious identification with the patient's disowned femininity and narcissistic vulnerability is seen as central to this countertransference “stranglehold.” Release from the analyst's masochistic position comes through a shift in her own affective participation. The importance of the analyst's recognizing her own unconscious contributions to this sadomasochistic dynamic is emphasized and elaborated. Discussion also focuses on the relevance of gender to the issue of countertransference fear, as illustrated in this particular male patient—female analyst dyad.     

Infants' discrimination of faces by using biological motion cues

We report two experiments in which we used animated averaged faces to examine infants' ability to perceive and discriminate facial motion. The faces were generated by using the motion recorded from the faces of volunteers while they spoke. We tested infants aged 4-8 months to assess their ability to discriminate facial motion sequences (condition 1) and discriminate the faces of individuals (condition 2). Infants were habituated to one sequence with the motion of one actor speaking one phrase. Following habituation, infants were presented with the same sequence together with motion from a different actor (condition 1), or a new sequence from the same actor coupled with a new sequence from a new actor (condition 2). Infants demonstrated a significant preference for the novel actor in both experiments. These findings suggest that infants can not only discriminate complex and subtle biological motion cues but also detect invariants in such displays.     

Retrieval induces hippocampal-dependent reconsolidation of spatial memory

Nonreinforced retrieval can cause extinction and/or reconsolidation, two processes that affect subsequent retrieval in opposite ways. Using the Morris water maze task we show that, in the rat, repeated nonreinforced expression of spatial memory causes extinction, which is unaffected by inhibition of protein synthesis within the CA1 region of the dorsal hippocampus. However, if the number of nonreinforced retrieval trials is insufficient to induce long-lasting extinction, then a hippocampal protein synthesis-dependent reconsolidation process recovers the original memory. Inhibition of hippocampal protein synthesis after reversal learning sessions impairs retention of the reversed preference and blocks persistence of the original one, suggesting that reversal learning involves reconsolidation rather than extinction of the original memory. Our results suggest the existence of a hippocampal protein synthesis-dependent reconsolidation process that operates to recover or update retrieval-weakened memories from incomplete extinction.     

EMOTIONAL CONTAGION Gender and Occupational Differences

Theorists have proposed that men and women and those in various occupational groups should differ in their susceptibility to primitive emotional contagion. Study 1 was designed to explore the extent to which gender and occupation affected respondents' self-reports of emotional contagion, as measured by the Emotional Contagion (EC) scale. As predicted, women in a variety of occupations secured higher total EC scores than did men. Study 2 was designed to determine the extent to which gender affected self-reports of emotional contagion (again as measured by the EC scale) and actual responsiveness to others' emotions. As predicted, women received higher EC scores, reported sharing the targets' emotions to a greater extent, and were rated by judges as displaying more emotional contagion than did men.     

Stress,Sex Differences,and Coping Strategies Among College Students

The sources of stress (academics, financial, family, social, and daily hassles) and coping strategies (self-help, approach, accommodation, avoidance, and self-punishment) of 166 college students were examined. The relationship between sex, specific sources of stress, and coping strategies was also investigated. Students completed a stress assessment inventory and a stress coping inventory based on a 5-factor revised COPE model (Zuckerman and Gagne Journal of Research in Personality, 37:169–204, 2003). Results found that college women reported a higher overall level of stress and greater use of emotion-focused coping strategies than college men. College men and women also reported different coping strategies for different stressors; however the use of emotion-focused coping strategies dominated over problem-solving strategies for both men and women. These results have implications for designing stress reduction workshops that build on the existing adaptive emotion-focused strategies of college students.