Intra-amygdala infusion of the protein kinase Mzeta inhibitor ZIP disrupts foreground context fear memory

Protein kinase Mzeta has been the subject of much recent interest, as it is the only molecule currently identified to maintain memory. Despite the wealth of studies investigating PKMζ in memory, questions remain about which types of memory PKMζ supports. Further, it is unclear how long the inhibitor of PKMz, ζ-pseudosubstrate inhibitory peptide (ZIP) remains in the brain after infusion. Here, we demonstrate that foreground context fear memory requires PKMζ activity in the amygdala. We also show that ZIP is fully cleared from the brain by 24h after infusion. These data contribute to a growing body of literature that demonstrates that PKMζ plays a key role in maintaining amygdala-dependent memory and provides new information about the degradation timecourse of the most commonly used inhibitor of PKMζ, ZIP.     

Are head cues necessary for goats (Capra hircus) in recognising group members?

In this study, we investigated whether goats can distinguish a member of their own group from one belonging to a different group even when the head of the goat in question cannot be seen. In the experiment, a total of 45 adult female goats (walkers) were trained to walk along a passageway at the end of which they learnt to expect food (trial run). Walking down this corridor, they passed another adult female goat (stimulus goat) whose trunk and hind legs alone were visible. Using 19 individuals, ten pairs of stimulus goats consisting of one goat from the walker's group and one from a different group were matched in terms of body size, constitution, colour and coat length. In addition, the stimulus goat from the same group as the walker had to be higher ranking than the latter to avoid being attacked. The walkers completed two, four or six trial runs depending on the number of pairs suitable for a given walker. The walker's exploratory behaviour (observing and sniffing at the stimulus goat) was recorded. Data from 109 trial runs were analysed using generalised linear mixed-effects models with crossed random effects. On average, the walker spent a total of 8.7?s exploring the stimulus goat visually and olfactorily if the latter was from a different group and only about half as long (4.2?s) if it was from her own group. In particular, the time a walker spent observing a stimulus goat whilst approaching the latter was significantly longer if the stimulus goat belonged to a different group than to her own (2.5?s as opposed to 1.4?s). Moreover, a stimulus goat from a different group was sniffed at significantly longer (4.6?s) than one from the same group (1.9?s). Results suggest that goats can easily discriminate between members of their own group and those of a different group even when the latter's heads are hidden. Olfactory and visual cues are probably important for identifying group members.     

Comparing implementation intention interventions in relation to young adults’ intake of fruit and vegetables

This study tests whether the effectiveness of implementation intention-based interventions to increase fruit and vegetable intake in a young adult population can be enhanced using additional pre-intervention instructions and alternative formats; namely, an ‘if-then’ implementation intention versus a more general, ‘global’ plan that does not explicitly link a situational cue with a goal-directed response. Participants (N?=?557) completed pre-test measures of planning, motivation and behaviour with respect to increasing their fruit and vegetable intake before being randomised to a 3 (intervention format: control vs. ‘if-then’ vs. ‘global’ implementation intentions)?×?2 (pre-intervention instruction vs. no pre-intervention instruction) between-participants design. Results revealed a significant intervention format by time interaction, such that intake significantly increased by 0.50 portions in the if-then format condition compared with 0.31 in the global format and 0.01 in the control condition. These results suggest that ‘if-then’ manipulations are superior in promoting behaviour change in an applied setting. The use of pre-intervention instructions had no additional effect on behaviour, providing evidence for the efficacy of implementation intentions even when experimenter demand is reduced. Evidence is also presented to suggest that reported increases in intake are not related to demand characteristics.     

Neural basis of individual differences in impulsivity: contributions of corticolimbic circuits for behavioral arousal and control

The objective of the current study was to analyze the neural correlates of behavioral arousal and inhibitory control as they relate to individual differences in impulsivity via well-established functional MRI amygdala reactivity and prefrontal inhibitory control paradigms in healthy adult subjects. Impulsivity correlated positively with activity of the bilateral ventral amygdala, parahippocampal gyrus, dorsal anterior cingulate gyrus (BA 32), and bilateral caudate. Conversely, impulsivity correlated negatively with activity of the dorsal amygdala and ventral prefrontal cortex (BA 47). Together, these findings suggest that dispositional impulsivity is influenced by the functional interplay of corticolimbic behavioral arousal and control circuits.     

Aging and autobiographical memory: dissociating episodic from semantic retrieval

Cognitive aging research documents reduced access to contextually specific episodic details inolder adults, whereas access to semantic or other nonepisodic information is preserved or facilitated. The present study extended this finding to autobiographical memory by using a new measure; the Autobiographical Interview. Younger and older adults recalled events from 5 life periods. Protocols were scored according to a reliable system for categorizing episodic and nonepisodic information. Whereas younger adults were biased toward episodic details reflecting happenings, locations, perceptions, and thoughts, older adults favored semantic details not connected to a particular time and place. This pattern persisted after additional structured probing for contextual details. The Autobiographical Interview is a useful instrument for quantifying episodic and semantic contributions to personal remote memory.     

Colour constancy in goldfish and man: influence of surround size and lightness

Colour constancy was investigated by using a series of 10 simultaneously presented surface colours ranging in small steps from green through gray to red-purple. Goldfish were trained to select one medium test field when the entire setup was illuminated with white light. In the tests, either red or green illumination was used. Colour constancy, as inferred from the choice behaviour, was perfect under green illumination when the test fields were presented on a gray or a white background, but imperfect on a black background. Under red illumination and a white background, however, colour constancy was overcompensated. Here, a colour contrast effect was observed. The influence of background lightness was also found when the surround was restricted to a narrow annulus of 4-11 mm width (test field diameter: 14 mm). By applying colour metrics it could be shown that the von Kries coefficient law can describe the overall effect of colour constancy. For an explanation of the effect of surround size and lightness, lateral inhibitory interactions have to be assumed in addition, which are also responsible for simultaneous colour contrast. Very similar results were obtained in experiments with the same colours in human subjects. They had to name the test field appearing 'neutral' under the different illumination and surround conditions, as tested in the goldfish experiment.     

Transparency and self-disclosure in family therapy: dangers and possibilities

Therapy is a paid intimate relationship that thrusts clients and therapists into navigating personal and professional boundaries. When, where, why, and how is it appropriate and ethical for family therapists to be transparent, and when is it damaging? Theorists take varied stances from Haley's position of tight boundaries around therapist disclosure—whether in treatment or training—to the narrative viewpoint that therapists should be transparent about models of therapy, personal values, and life experiences that inform their practice and beliefs. However, these positions are not research based, and theorists who support disclosure offer few guidelines other than general statements. This article examines the history of ideas about disclosure in six major family therapy models, and the dangers and possibilities of transparency. It looks at the research on self‐disclosure in individual therapy and whether and how it could apply to family therapy. Guidelines are proposed that take into account the multiple social identities of therapists and clients, and issues of safety and transparency.     

Students' perspectives on their high school experience

This study explored students' levels of belonging and engagement in high school by obtaining their perspectives on the instruction, teachers, friends, and activities in their school. We interviewed 33 students from seven comprehensive high schools in Richmond, Virginia. Students indicated that they were more engaged when the instructional program included authentic learning experiences, teachers who provided challenging activities and showed interest in student learning, and a school day that supported interpersonal relationships with peers and adults. It was concluded that, to promote belonging and engagement, school personnel should attend to the quality of student learning and relationships.