Cholinergic-dopaminergic interactions in cognitive performance

Both acetylcholinergic (ACh) and dopaminergic (DA) systems have been found to be crucial for the maintenance of accurate cognitive performance. In a series of studies examining those aspects of cognitive function revealed by the radial-arm maze, we have found that these two neurotransmitter systems interact in a complex fashion. Choice accuracy deficits in the radial-arm maze can be induced by blockade of either muscarinic- or nicotinic-ACh receptors. The choice accuracy deficit induced by blockade of muscarinic receptors with scopolamine can be reversed by the DA receptor blocker, haloperidol. The specific DA D1 blocker SCH 23390 also has this effect, whereas the specific D2 blocker raclopride does not, implying that it is D1 blockade that is critical for reversing the scopolamine effect. On the other hand, the choice accuracy deficit induced by nicotinic blockade with mecamylamine is potentiated by haloperidol. This effect is also seen with the D2 antagonist raclopride, but not with the D1 antagonist SCH 23390, implying that it is the D2 receptor which is important for the potentiation of the mecamylamine effect. The relevance of the D2 receptor for nicotinic actions on cognitive function is emphasized by the finding that the selective D2 agonist LY 171555 reverses the choice accuracy deficit caused by mecamylamine. Nicotinic and muscarinic blockade are synergistic in the deficit they produce. Antagonist doses subthreshold when given alone produce a pronounced impairment when given together. This latter deficit can be reversed by the D2 agonist LY 171555. These studies have outlined the complex nature of ACh-DA interactions with regard to cognitive function. Possible neural circuits for these interactions are discussed. The effectiveness of these selective DA treatments in reversing cognitive deficits due to ACh underactivation suggests a novel approach to treating cognitive dysfunction in syndromes such as Alzheimer's disease.     

Research on working women: A report card of 22 journals

The study was part of an official project of the Women in Management Division of the Academy of Management to examine the status of research in gender issues in organizations. It specifically looked at 22 major scholarly and trade journals plus the Proceedings of the Academy of Management for the six-year period of 1983–1988 to determine quantity, patterns, and trends in publication of research on issues of interest to the domain of the division. Results show a downward trend in gender-issue publication at a time when working women are becoming an ever-increasing percentage of the work force. This is particularly true of the so-called prestige journals. Psychology journals accounted for 64% of the total, management 13.4%, personnel 19%, and Proceedings 3.5%. Implications for research and careers are discussed.A shorter, less-complete version of this paper was presented in summary form at the annual meeting of The Academy of Management in Washington, DC, August 1989 as part of a symposium for the Women in Management Division.     

NUMBER AND QUALITY OF ROLES

We used longitudinal personality data to test whether number and quality of roles were associated with health and self-enhancement in 100 privileged midlife women. Number of roles (from the set of partner, parent, and worker) was not related to autonomy, individuality, and complexity, as had been hypothesized, but to respect for norms, being well-organized considering oneselt like other people. Through women with one role were lower in well-being than women with more than one, hierarchical multiple regression showed no advantage to number of roles after psychological health at age 21 was taken in to account. However, quality of role, as assessed by marital satisfaction and status level in work, was associated with contentment and effective functioning, respectively, even after antecedent psychological functioning was taken into account. Particular roles were associated with particular advantages. The enhancement model of the accumulation of roles is compared with Erikson's theory of the development of personality.     

Failure to detect changes to attended objects in motion pictures

Our intuition that we richly represent the visual details of our environment is illusory. When viewing a scene, we seem to use detailed representations of object properties and interobject relations to achieve a sense of continuity across views. Yet, several recent studies show that human observers fail to detect changes to objects and object properties when localized retinal information signaling a change is masked or eliminated (e.g., by eye movements). However, these studies changed arbitrarily chosen objects which may have been outside the focus of attention. We draw on previous research showing the importance of spatiotemporal information for tracking objects by creating short motion pictures in which objects in both arbitrary locations and the very center of attention were changed. Adult observers failed to notice changes in both cases, even when the sole actor in a scene transformed into another person across an instantaneous change in camera angle (or “cut”).     

Referenzsemantik in der Partnermodellierung

How can we explain that an assertion on something perceived can be understood in the same manner by somebody who cannot perceive that scene? This problem bases the interest in computational linguistics in how listener modeling could possibly be harmonized with reference semantics. Mental images substituting real perception appear as a way out. The architecture of the listener model has to be adapted to the creation and use of such pictorial data structures. Furthermore, the relation between the latter and a verbal (i. e., propositional) representation must be understood. The resulting architecture of a listener model with reference semantics can be employed to solve communicational problems from three general classes in a better way, as is demonstrated by an example implementation.     

MATERNITY LEAVE AND WOMEN'S MENTAL HEALTH

The Wisconsin Maternity Leave and Health Study addresses an important policy issue, parental leave, by investigating the work status, maternity leave, and mental health of 570 women. In the longitudinal design, the women, all of whom were living with a husband or partner, were interviewed during the fifth month of pregnancy, 1 month postpartum, and 4 months postpartum. At 4 months postpartum, full-time workers, part-time workers, and homemakers did not differ in depression or anger, but full-time workers showed elevated anxiety compared with the other two groups. In multiple regression analyses, length of leave interacted significantly with marital concerns when predicting depression; women who took a short leave (6 weeks or less) and were high on marital concerns had the highest depression scores. Short maternity leave can be conceptualized as a risk factor that, when combined with other risk factors such as marital concerns, places women at greater risk for depression.     

The mediating role of anxiety in self-reported somatic complaints of depressed adolescents

This study examined the mediating role of anxiety in the self-reports of somatic complaints in 96 depressed adolescent inpatients. Sixty-four subjects with major depressive episodes and comorbid anxiety disorders (MDE-A) determined from the Diagnostic Interview for Children and Adolescents-Revised (DICA-R) reported significantly more somatic complaints than 32 adolescents having major depressive episodes without comorbid anxiety (MDE). An analysis of covariance demonstrated that, with anxiety symptoms controlled, MDE and MDE-A groups did not differ significantly in somatic complaints. A hierarchical multiple-regression analysis revealed that, with demographic and anxiety symptoms controlled, depressive symptoms did not contribute to the explanation or prediction of somatic complaints. The results suggest that anxious, but not depressive symptoms, are independently associated with somatic complaints. The results are discussed in light of new affective models of psychopathology.     

Making sense: The work of Eugene Gendlin

This and the following papers were presented at a symposium organized by David M. Levin honoring the work of Eugene Gendlin at meetings of the Society for Phenomenology and the Human Sciences, Boston, October, 1992.     

Accreditation Standards for University and College Counseling Centers

The accreditation standards outlined in the article are used by the International Association of Counseling Services, Inc., as the basis for the formal accreditation of college and university counseling programs throughout the United States and Canada. They reflect the program elements and practice standards that are deemed essential in a counseling center that provides high-quality services to students.