Caudate-putamen lesions in the rat may impair or potentiate maze learning depending upon availability of stimulus cues and relevance of response cues

In Experiment 1 rats were required to learn a Y-maze in which reward was made available after a given response (e.g. a left turn) regardless of which arm was used as the start-box. Subjects with lesions of the caudate-putamen showed a deficit on this response-learning task compared with control subjects (unoperated animals and rats having lesions of the posterior cortex). In Experiment 2 rats with caudate-putamen lesions were unimpaired when the direction of the turn required to reach the correct goal-box (identified by means of a salient visual intra-maze cue) varied from trial to trial. In the absence of salient intramaze cues, but with enriched room (extra-maze) cues, the rats with caudate-putamen lesions were superior to controls on this task. It is argued that caudate-putamen lesions disrupt a mechanism responsible for processing information about responses, but that the other (spatial) mechanisms responsible for maze-learning remain intact and that caudate-putamen lesions may enhance performance on spatial tasks for which information about responses is irrelevant.     

Surface dyslexia

Two cases of surface dyslexia are described. In this disorder, irregular words such as broad or steak are less likely to be read aloud correctly than regularly-spelled words like breed or steam; and when irregular words are misread the incorrect response is often a regularisation (reading broad as "brode" and steak as "steek, for example). When reading comprehension was tested, homophones were often confused with each other: for example, soar was understood as an instrument for cutting, and route was understood as being part of a tree. Spelling was also impaired, with the majority of spelling errors being phonologically correct: for example, "search" was spelled surch. "Orthographic" errors in reading aloud (omitting, altering, adding or transposing letters) were also noted. These errors were not due to defects at elementary levels of visual processing.

One of our cases was a developmental dyslexic, and the other was an acquired dyslexic. The close similarity of their reading and spelling performance supports the view that surface dyslexia can cccur both as a developmental and as an acquired dyslexia.

A theoretical interpretation of surface dyslexia within the framework of the logogen model (including a grapheme-phoneme correspondence system for reading non-words) was offered: defects within the input logogen system, and in communication from that system to semantics, were postulated as responsible for most of the symptoms of surface dyslexia.     

Disruptive innovations for designing and diffusing evidence-based interventions

Evidence-based therapeutic and preventive intervention programs (EBIs) have been growing exponentially. Yet EBIs have not been broadly adopted in the United States. In order for our EBI science to significantly reduce disease burden, we need to critically reexamine our scientific conventions and norms. Innovation may be spurred by reexamining the traditional biomedical model for validating, implementing, and diffusing EBI products and science. The model of disruptive innovations suggests that we reengineer EBIs on the basis of their most robust features in order to serve more people in less time and at lower cost. A disruptive innovation provides a simpler and less expensive alternative that meets the essential needs for the majority of consumers and is more accessible, scalable, replicable, and sustainable. Examples of disruptive innovations from other fields include minute clinics embedded in retail chain drug stores, $2 generic eyeglasses, automated teller machines, and telemedicine. Four new research approaches will be required to support disruptive innovations in EBI science: synthesize common elements across EBIs; experiment with new delivery formats (e.g., consumer controlled, self-directed, brief, paraprofessional, coaching, and technology and media strategies); adopt market strategies to promote and diffuse EBI science, knowledge, and products; and adopt continuous quality improvement as a research paradigm for systematically improving EBIs, based on ongoing monitoring data and feedback. EBI science can have more impact if it can better leverage what we know from existing EBIs in order to inspire, engage, inform, and support families and children to adopt and sustain healthy daily routines and lifestyles. (PsycINFO Database Record (c) 2012 APA, all rights reserved).     

A note on consistency of non-parametric rank tests and related rank transformations

The extent to which rank transformations result in the same statistical decisions as their non‐parametric counterparts is investigated. Simulations are presented using the Wilcoxon–Mann–Whitney test, the Wilcoxon signed‐rank test and the Kruskal–Wallis test, together with the rank transformations and t and F tests corresponding to each of those non‐parametric methods. In addition to Type I errors and power over all simulations, the study examines the consistency of the outcomes of the two methods on each individual sample. The results show how acceptance or rejection of the null hypothesis and differences in p‐values of the test statistics depend in a regular and predictable way on sample size, significance level, and differences between means, for normal and various non‐normal distributions.     

Gene-environment interplay in the association between pubertal timing and delinquency in adolescent girls

Early pubertal timing places girls at elevated risk for a breadth of negative outcomes, including involvement in delinquent behavior. While previous developmental research has emphasized the unique social challenges faced by early maturing girls, this relation is complicated by genetic influences for both delinquent behavior and pubertal timing, which are seldom controlled for in existing research. The current study uses genetically informed data on 924 female-female twin and sibling pairs drawn from the National Longitudinal Study of Adolescent Health to (1) disentangle biological versus environmental mechanisms for the effects of early pubertal timing and (2) test for gene-environment interactions. Results indicate that early pubertal timing influences girls' delinquency through a complex interplay between biological risk and environmental experiences. Genes related to earlier age at menarche and higher perceived development significantly predict increased involvement in both nonviolent and violent delinquency. Moreover, after accounting for this genetic association between pubertal timing and delinquency, the impact of nonshared environmental influences on delinquency are significantly moderated by pubertal timing, such that the nonshared environment is most important among early maturing girls. This interaction effect is particularly evident for nonviolent delinquency. Overall, results suggest early maturing girls are vulnerable to an interaction between genetic and environmental risks for delinquent behavior.     

Philosophy and Its Pitfalls

Philosophy is an ambitious, speculative practice, aimed at finding out what wisdom is and how to attain it, in so far as that can be done by explicit discussion and argument. A likely pitfall of any such enterprise is that it loses touch with concerns in human life outside itself and becomes scholastic, in the pejorative sense. Academic institutions which encourage wide and outward‐looking intellectual sympathies, and which do not reward narrow point‐scoring specialism, are helpful in resisting the tendency to scholasticism. The Moral Sciences Tripos at Cambridge might have provided some of the elements of such a setting, by framing an academic structure in which philosophy was studied in conjunction with other subjects in the humanities and social sciences. As things actually developed, that possibility was not realised. Nevertheless, philosophy at Cambridge maintained vigour and significance, through the intellectual freedom and encouragement it provided to some notable individual philosophers.     

Falling From Grace: Understanding an Ethical Sanctioning Experience

Although an ethical sanction is viewed as an incredibly stressful event for professional counselors, the experience of being sanctioned is not well known. This article provides an overview of the sanctioning process, a discussion of professional silence, and a case example of a sanctioning experience for a counselor. The sanctioning experience is described in a 3‐stage response sequence and is illustrated with journal entries from a sanctioned counselor. Response interventions for each stage are suggested, and implications for the counseling profession are offered.