Tolerance to and residual effects of cocaine in squirrel monkeys depend on reinforcement-schedule parameter.

Lever pressing by 4 squirrel monkeys was maintained under a three-component multiple fixed-ratio schedule of food presentation; components differed with respect to ratio size. For each monkey, acute administration of cocaine (0.03 to 1.3 mg/kg, i.m.) produced dose-dependent decreases in overall response rate in each component. During repeated daily administration of 1.0 mg/kg of cocaine, tolerance developed to the rate-decreasing effects under each of the ratio contingencies, but developed to a greater extent and was evident in earlier parts of sessions for performance under the smaller ratios. Response rates of 2 monkeys increased above nondrug control levels despite the putative reinforcer not being consumed during the session. When saline or a smaller dose of cocaine was substituted for 1.0 mg/kg, response rates often were suppressed below nondrug control-level responding. This suppressive effect was observed in each monkey and was more likely to be observed and/or to be of greater magnitude in large-ratio components for 3 of the 4 monkeys. When saline was administered chronically at the end of the chronic-drug phase, response rates remained suppressed in the large-ratio component for 2 of the monkeys. There was, therefore, a schedule-dependent dissociation between behavioral tolerance and the residual effects: Tolerance was greater when small ratios were arranged, whereas the residual effects were more pronounced when larger ratios were arranged.     

Behavioral economics of drug self-administration. II. A unit-price analysis of cigarette smoking.

In behavioral economics, the ratio of response requirement to reinforcer magnitude is referred to as unit price. Previous research with nonhuman subjects has demonstrated that (a) comparable amounts of food are consumed at the same unit price even though different response requirements and reinforcer magnitudes comprise that unit price and (b) increases in unit price decrease food consumption in a positively decelerating fashion. The present study assessed the generality of these findings to the cigarette smoking of 5 human volunteers. During approximately 18 3-hr sessions, various combinations of response requirement (fixed-ratio 200, 400, and 1,600) and reinforcer magnitude (1, 2, and 4 puffs per bout) were arranged. Consumption (i.e., the number of puffs) generally was comparable at the same unit price independent of the response requirement and reinforcer magnitude comprising that unit price. In addition, increasing unit price generally decreased consumption in a positively decelerating fashion. These results extend the generality of the unit-price analysis to human cigarette smoking. Moreover, these results further support the position that reinforcer magnitude and response requirement are functionally equivalent and interact to determine consumption. The concept of unit price, by integrating and summarizing the effects of those two operations, provides a more parsimonious explanation of the results than do separate evaluations of the effects of response requirement and reinforcer magnitude.     

Fitting longitudinal reduced-rank regression models by alternating least squares

An alternating least squares method for iteratively fitting the longitudinal reduced-rank regression model is proposed. The method uses ordinary least squares and majorization substeps to estimate the unknown parameters in the system and measurement equations of the model. In an example with cross-sectional data, it is shown how the results conform closely to results from eigenanalysis. Optimal scaling of nominal and ordinal variables is added in a third substep, and illustrated with two examples involving cross-sectional and longitudinal data.Financial support by the Institute for Traffic Safety Research (SWOV) in Leidschendam, The Netherlands is gratefully acknowledged.     

Fixation-point offsets reduce the latency of saccades to acoustic targets

If an observer’s fixation point is extinguished just prior to the onset of a peripheral target, the latency to saccade to that target is reduced. We show that this "gap effect" is not specific to visual targets. Observers made saccades to a light flash or to a white-noise burst. A warning tone was presented on every trial to control for the possible warning effect of the fixation-point offset. For both target modalities, saccade latencies were significantly reduced when the fixation point was extinguished 200 msec prior to the target onset. Implications of this outcome for interpretations of the gap effect are considered. It is argued that the presence of a gap effect for tones, in conjunction with previous findings, is consistent with the hypothesis that the gap effect is produced by a facilitation of premotor processes in the superior colliculus.     

A note on partitioned determinants

A formula for the determinant of a partitioned matrix, possibly with singular submatrices, is derived and applied to some psychometric and numerical problems.     

Generalized eigenvalue problems with positive semi-definite matrices

In a recent paper in this journal McDonald, Torii, and Nishisato show that generalized eigenvalue problems in which both matrices are singular can sometimes be solved by reducing them to similar problems of smaller order. In this paper a more extensive analysis of such problems is used to sharpen and clarify the results of McDonald, Torii, and Nishisato. Possible extensions are also indicated. The relevant mathematical literature is reviewed briefly.     

Scene perception: Detecting and judging objects undergoing relational violations

Five classes of relations between an object and its setting can characterize the organization of objects into real-world scenes. The relations are (1) Interposition (objects interrupt their background), (2) Support (objects tend to rest on surfaces), (3) Probability (objects tend to be found in some scenes but not others), (4) Position (given an object is probable in a scene, it often is found in some positions and not others), and (5) familiar Size (objects have a limited set of size relations with other objects). In two experiments subjects viewed brief (150 msec) presentations of slides of scenes in which an object in a cued location in the scene was either in a normal relation to its background or violated from one to three of the relations. Such objects appear to (1) have the background pass through them, (2) float in air, (3) be unlikely in that particular scene, (4) be in an inappropriate position, and (5) be too large or too small relative to the other objects in the scene. In Experiment I, subjects attempted to determine whether the cued object corresponded to a target object which had been specified in advance by name. With the exception of the Interposition violation, violation costs were incurred in that the detection of objects undergoing violations was less accurate and slower than when those same objects were in normal relations to their setting. However, the detection of objects in normal relations to their setting (innocent bystanders) was unaffected by the presence of another object undergoing a violation in that same setting. This indicates that the violation costs were incurred not because of an unsuccessful elicitation of a frame or schema for the scene but because properly formed frames interfered with (or did not facilitate) the perceptibility of objects undergoing violations. As the number of violations increased, target detectability generally decreased. Thus, the relations were accessed from the results of a single fixation and were available sufficiently early during the time course of scene perception to affect the perception of the objects in the scene. Contrary to expectations from a bottom-up account of scene perception, violations of the pervasive physical relations of Support and Interposition were not more disruptive on object detection than the semantic violations of Probability, Position and Size. These are termed semantic because they require access to the referential meaning of the object. In Experiment II, subjects attempted to detect the presence of the violations themselves. Violations of the semantic relations were detected more accurately than violations of Interposition and at least as accurately as violations of Support. As the number of violations increased, the detectability of the incongruities between an object and its setting increased. These results provide converging evidence that semantic relations can be accessed from the results of a single fixation. In both experiments information about Position was accessed at least as quickly as information on Probability. Thus in Experiment I, the interference that resulted from placing a fire hydrant in a kitchen was not greater than the interference from placing it on top of a mail ? in a street scene. Similarly, violations of Probability in Experiment II were not more detectable than violations of Position. Thus, the semantic relations which were accessed included information about the detailed interactions among the objects—information which is more specific than what can be inferred from the general setting. Access to the semantic relations among the entities in a scene is not deferred until the completion of spatial and depth processing and object identification. Instead, an object's semantic relations are accessed simultaneously with its physical relations as well as with its own identification.     

Perception of autonomic reactions and actual heart rate in phobic patients

The relationship between perceived physiological arousal and actual heart-rate reactions was studied in two behavioral test situations. The subjects were 70 phobic patients (34 social phobics and 36 claustrophobics) who were given the general form of the Autonomic Perception Questionnaire about 1 month before the respective behavioral test and the specific form immediately after the test. The results showed significant correlations between APQ and actual heart rate for the social phobics, while the picture was more complicated for the claustrophobics. The implications of these results are discussed.This research was supported by Grant 05452 from the Swedish Medical Research Council.     

The influence of relative frequencies of pure and mixed stimuli on mixture suppression in taste

In experiments on saltiness suppression in NaCL-sucrose mixtures, the amount of suppression depends not only on the suppressing sucrose component in the mixture, but also on the relative frequencies of pure NaCL stimuli and mixed stimuli in the series. The observed variation of mixture suppression as a function of these frequencies can be explained by Helson’s adaptation level theory.     

Treatment of handwriting problems utilizing EMG biofeedback training.

The effects of EMG biofeedback training on cursive handwriting were investigated for 4 girls and 5 boys in Grade 4. A significant reduction in EMG between the first baseline session and the last training session was obtained. Four of 5 characteristics of handwriting improved significantly. The need for carefully designed research comparing EMG biofeedback training and relaxation training was indicated. A self-control factor in handwriting was hypothesized.