Parental negotiations of the moral terrain of risk in relation to young people with intellectual disabilities

This paper draws upon parental accounts from a study of the process of transition for a cohort of 28 young people with relatively severe intellectual disabilities who left special schools in 2004 and 2005 in two adjacent English localities. This paper examines how parents negotiate these boundaries and position themselves in relation to risk. A primary concern identified by parents during this transition period focuses on the risk of harm facing these vulnerable young people (whether through accidents or through sexual, emotional, physical or financial abuse) as they move into the adult world. These concerns are juxtaposed with discourses that increasingly promote the possibilities for people with intellectual disabilities to express and follow their own wishes and aspirations. For example, the policy agenda in England and Wales actively endorses the start of adult life as a time of opportunity for young people and promotes the values of independence and choice. In accounting for the management of risk in the young people's lives, we conclude that parents navigate complex boundaries between being seen to be over‐protective and ‘letting go’; between trusting others to act in the young adults' best interests and allowing these young people the autonomy to negotiate risk. Copyright © 2008 John Wiley & Sons, Ltd.     

Does Mastery of ABLA Level 6 Make it Easier for Individuals with Developmental Disabilities to Learn to Name Objects?

Level 6 of the Assessment of Basic Learning Abilities (ABLA) assesses the ease or difficulty with which persons with developmental disabilities are able to learn a two-choice auditory-visual discrimination. We investigated whether participants who passed ABLA Level 6 (Group 1) would more readily learn object naming (vocal tacts) than those who failed ABLA Level 6 (Group 2). The groups were matched on the Communication Subscale of the Vineland Adaptive Behavior Scale. Results indicated that Group 1 met mastery criterion for a significantly larger number of naming responses and in significantly fewer trials than Group 2. The implications for language training are discussed.     

Extinction circuits for fear and addiction overlap in prefrontal cortex

Extinction is a form of inhibitory learning that suppresses a previously conditioned response. Both fear and drug seeking are conditioned responses that can lead to maladaptive behavior when expressed inappropriately, manifesting as anxiety disorders and addiction, respectively. Recent evidence indicates that the medial prefrontal cortex (mPFC) is critical for the extinction of both fear and drug-seeking behaviors. Moreover, a dorsal-ventral distinction is apparent within the mPFC, such that the prelimbic (PL-mPFC) cortex drives the expression of fear and drug seeking, whereas the infralimbic (IL-mPFC) cortex suppresses these behaviors after extinction. For conditioned fear, the dorsal-ventral dichotomy is accomplished via divergent projections to different subregions of the amygdala, whereas for drug seeking, it is accomplished via divergent projections to the subregions of the nucleus accumbens. Given that the mPFC represents a common node in the extinction circuit for these behaviors, treatments that target this region may help alleviate symptoms of both anxiety and addictive disorders by enhancing extinction memory.Emotional memories, both in the aversive and appetitive domains, are important for guiding behavior. Regulating the expression of these memories is critical for mental health. Extinction of classical conditioning is one form of emotion regulation that is easily modeled in animals. In the aversive domain, a conditioned stimulus (CS) is typically paired with a shock, while in the appetitive domain, a CS is paired with the availability of food or drug reward. Repeated presentation of the CS in the absence of the reinforcer leads to extinction of conditioned fear or drug-seeking behaviors. In recent years, there have been great advances in our understanding of the neural circuitry responsible for this form of inhibitory learning (for reviews, see Cammarota et al. 2005; Maren 2005; Myers and Davis 2007; Quirk and Mueller 2008). The prefrontal cortex has been strongly implicated in fear expression (Powell et al. 2001; Vidal-Gonzalez et al. 2006; Corcoran and Quirk 2007) and fear extinction (Herry and Garcia 2002; Milad and Quirk 2002; Gonzalez-Lima and Bruchey 2004; Hugues et al. 2004; Burgos-Robles et al. 2007; Hikind and Maroun 2008; Lin et al. 2008; Mueller et al. 2008; Sotres-Bayon et al. 2008), and more recently, in expression of drug seeking after extinction (Peters et al. 2008a,b). These findings are consistent with a well-documented role of the prefrontal cortex in executive function and emotional regulation (Miller 2000; Fuster 2002; Quirk and Beer 2006; Sotres-Bayon et al. 2006).In this review, we propose that the medial prefrontal cortex (mPFC) regulates the expression of both fear and drug memories after extinction, through divergent projections to the amygdala and nucleus accumbens, respectively. Extinction failure in the aversive domain can lead to anxiety disorders (Delgado et al. 2006; Milad et al. 2006), while extinction failure in the appetitive domain can lead to relapse in addicted subjects (Kalivas et al. 2005; Garavan and Hester 2007). A common neural circuit for extinction of fear and drug memories would suggest shared mechanisms and treatment strategies across both domains.     

Interpreting conjunctions

The interpretation generated from a sentence of the form P and Q can often be different to that generated by Q and P, despite the fact that and has a symmetric truth-conditional meaning. We experimentally investigated to what extent this difference in meaning is due to the connective and and to what extent it is due to order of mention of the events in the sentence. In three experiments, we collected interpretations of sentences in which we varied the presence of the conjunction, the order of mention of the events, and the type of relation holding between the events (temporally vs. causally related events). The results indicated that the effect of using a conjunction was dependent on the discourse relation between the events. Our findings contradict a narrative marker theory of and, but provide partial support for a single-unit theory derived from Carston (2002). The results are discussed in terms of conjunction processing and implicatures of temporal order.     

The trajectory of mathematics skills and working memory thresholds in girls with fragile X syndrome

Fragile X syndrome is a common genetic disorder associated with executive function deficits and poor mathematics achievement. In the present study, we examined changes in math performance during the elementary and middle school years in girls with fragile X syndrome, changes in the working memory loads under which children could complete a cognitive switching task, and the association between these two areas of function, in girls with fragile X syndrome relative to their peers. Our findings indicate that the trajectory of math and executive function skills of girls with fragile X differs from that of their peers and that these skills contribute to predicting math achievement and growth in math performance over time. Also, changes in math performance were associated with incremental increases in working memory demands, suggesting that girls with fragile X have a lower threshold for being able to perform under increasing task demands. Still, we found improvement in executive function performance between 10 and 12 years in girls with fragile X rather than a performance plateau as has been reported in other studies. The findings implicate the importance of early intervention in mathematics for girls with fragile X that addresses poor calculation skills, the supporting numerical skills, and deficits in executive functions, including working memory.     

Integration of weight and distance information in young children: The role of relational complexity

Young children's integration of weight and distance information was examined using a new methodology that combines a single-armed apparatus with functional measurement. Weight and distance values were varied factorially across the item set. Children estimated how far the beam would tilt when different numbers of weights were placed at different distances from the pivot. There was a developmental progression from non-systematic responding (3-year-olds) to responding based on a single variable, usually weight (4-year-olds) to responding based on integration of weight and distance (5-, 6- and 7-year-olds). Individual analyses revealed additive and multiplicative integration rules in children aged from 5 years. Weight–distance strategy complexity increased with age and was associated with better performance on independent measures of relational processing, especially the more complex items. Thus weight–distance integration involves processing of complex relational information. The findings enhance the explanatory power of Relational Complexity theory as a domain-general approach to cognitive development.     

Are dietary restraint scales valid measures of moderate- to long-term dietary restriction? Objective biological and behavioral data suggest not

Prospective studies indicate that elevated scores on dietary restraint scales predict bulimic symptom onset, but experiments indicate that assignment to dietary restriction interventions reduces bulimic symptoms. One possible explanation for the inconsistent findings is that the dietary restraint scales used in the former studies are not valid measures of dietary restriction. The authors previously found that dietary restraint scales were not inversely correlated with objective measures of short-term caloric intake (E. Stice, M. Fisher, & M. R. Lowe, 2004). In this follow-up report, 3 studies indicated that the Three-Factor Eating Questionnaire dietary restraint scale was not correlated with doubly labeled water estimated energy intake over 2-week periods or with observationally measured caloric intake over 3 months. Results from this study and others suggest that dietary restraint scales may not be valid measures of moderate- to long-term dietary restriction and imply the need to reinterpret findings from studies that have used dietary restraint scales.     

Support for hybrid models of the age of acquisition of English nouns

Age of acquisition (AoA) is a psycholinguistic construct that refers to the chronological age at which a given word is acquired. Contemporary theories of AoA have focused on lexical acquisition with respect to either the developing phonological or semantic systems. One way of testing the relative dominance of phonological or semantic contributions is through open-source psycholinguistic databases, whereby AoA may be correlated with other variables (e.g., morphology, semantics, phonology). We report two multiple regression analyses conducted on a corpus of English nouns with, respectively, subjective and objective AoA measures as the dependent variables and a combination of 10 predictors, including 2 semantic, 4 phonological, 2 morphological, and 2 lexical. This multivariate combination of predictors accounted for significant proportions of the variance of AoA in both analyses. We argue that this evidence supports hybrid models of language development that integrate multiple levels of processing—from sound to meaning.     

Efficacy of a program to encourage walking in VA elderly primary care patients: the role of pain

Pain may be a barrier or a negative outcome of initiating and maintaining an exercise program in elderly patients. The purpose of this study was to examine the role of pain in a program designed to increase walking for exercise in 181 veteran primary care patients (60 - 80 years). Self-reported physical activity (min-walked per week) and pain were assessed at baseline, 6, and 12 months. Walking for exercise increased over time without significant changes in pain. Analyses suggested that baseline pain was not a barrier to initiating or maintaining a walking exercise program, nor did increased walking influence reports of pain. These results suggest that patients can be encouraged to engage in physical activity, even if they are currently suffering from pain.