Aggressive behavior inhibition by serotonin and quipazine injected into the amygdala in the rat

The effects on aggressive behavior, open-field activity, and pain threshold of bilateral microinjections of serotonin (20 micrograms) and quipazine (20 micrograms), the direct serotonergic receptor agonist, into the cortico-medial amygdala were investigated in Wistar rats. Both drugs significantly prolonged the attack latency in isolated killer rats (predatory aggression model), and suppressed the incidence of aggressive postures/attacks in shock-induced fighting test (affective aggression). The only difference in the open-field behavior was the lower number of central square entries in drug-treated compared to saline-injected rats. None of the substances produced any significant change in jump threshold. It is concluded that stimulation of serotonin receptors within the amygdala produces inhibition of affective and muricidal behavior in isolated rats. The effect does not seem to be dependent on changes in general activity and pain sensitivity.     

Using interactive computing to expand intelligence testing: A critique and prospectus

Microcomputers can serve as automated testing stations for use in psychometric assessment. There are economic advantages in conducting aptitude and intelligence testing with such stations. It is possible to improve the quality of cognitive assessment by extending the range of cognitive abilities to be assessed? Two types of extension are considered; modifying and expanding testing procedures for psychological functions that are components of conventional tests, and the extension oof testing to psychological functions not generally assessed by conventional intelligence or aptitude tests. Computerized presentations will make relatively little difference in our ways of testing verbal comprehension. Computer controlled testing could well extend the ways in which we evaluate spatial-visual reasoning and memory. The impact of testing on the evaluation of reasoning is unclear. Computer-controlled item presentation makes it possible to conceive of tests of learning and attention, neither of which are evaluated in most psychometric programs today. The psychological nature of the abilities being assessed raises problems in assessment that are not addressed by the fact oof computer-control. Some research questions are identified that ought to be explored before testing is extended into these fields. Computer-controlled evaluation could be extended to the assessment of criterion performance, either in the normal working situation or in a simulation of the workplace. While evaluation of this sort does raise social questions, it clearly presents an opportunity to obtain validation data for psychological assessment studies.     

The borderline hypertensive rat (BHR): A new model for the study of environmental factors in the development of hypertension

While many studies have attempted to produce hypertension through the use of various environmental Stressors, few have succeeded in producing chronic elevations in blood pressure beyond levels considered to be borderline hypertensive (140–160 mm Hg systolic). The problem with most studies stems from the use of genetically normotensive animals and the selection of Stressors to which animals readily adapt. A new approach is suggested, which recognizes the role of genetics in human essential hypertension. Animals with one hypertensive parent do not develop spontaneous hypertension but show a more sensitive cardiovascular response to environmental Stressors than animals with normotensive parents. Preliminary studies revealed that animals with a mixed genetic history of hypertension develop spontaneous borderline hypertension. When subjected to shock-shock conflict, these borderline hypertensive rats (BHR) developed permanent hypertension that failed to abate even after a ten-week, shock-free recovery period. The hypertension was accompanied by elevated heart weight to body weight ratios and by significant cardiac pathology. Subsequent work has demonstrated that these animals also become hypertensive when fed a high-sodium diet. Finally, in a series of exercise studies, we found that BHRs subjected to a shock stressor were protected against stress-induced hypertension if they exercised daily. The potential of this model for studies of the mechanisms by which environmental variables produce permanent hypertension is discussed.     

Appetitive differential conditioning of the rabbit’s jaw movement response

Two experiments examined appetitive differential conditioning of the rabbit’s jaw movement response (JMR) in a two-phase procedure. The first phase entailed reinforced training with one conditioned stimulus (CS+), and the second phase involved intermixed presentations of CS+ and an unreinforced stimulus (CS?). In Experiment 1, CS+ was a 600-Hz tone, and CS-was either a 660-,1,000-, or 2,100-Hz tone. In Experiment 2, the magnitude of the water unconditioned stimulus (US) paired with CS+ was either 1, 3, or 9 ml. The experiments revealed that 1) the level of responding to CS-rose for several days and then declined over the remainder of training; 2) the physical similarity between CS+ and CS?directly affected the level of responding to CS?but had no discernable effect on the level of responding to CS+ ; and 3) US magnitude positively affected the level of responding to CS + and, to a lesser extent, CS?. The results are discussed in terms of their implications for Spence’s gradient interaction theory and Pavlov’s external inhibition hypothesis.     

Short-term memory processes in counting

Four experiments examined the memory processes used to maintain location in a counting sequence. In Experiment 1, subjects who rapidly counted forward omitted many repeated-digit numbers (e.g., 77), as found previously with backward counting. Subjects in Experiment 2 counted backward with normal auditory feedback or with headphones through which white noise was channeled. In both cases, repeated-digit errors predominated, suggesting that the contents of short-term memory, rather than auditory sensory memory, are checked during counting. In Experiment 3, subjects silently wrote counting responses, and the omission errors resembled those in vocal counting. Repetition errors were also found and attributed to phonological recoding failures. Articulatory suppression in Experiment 4 greatly increased the number of repetition errors in the written counting task. A model of the counting process was proposed according to which subjects keep track of their location in the counting sequence by monitoring phonologically coded short-term memory representations of the numbers.     

Frequency of neurologic-psychiatric findings in the late phase following minor and medium severe blunt craniocerebral injuries

The authors present a short review of the pertinent literature and report on their own neuropsychiatric findings following internal craniocerebral injuries, at the same time drawing attention to the necessity of psychological examination. Statistical comparisons with the international literature are complicated owing to the different classifications used for craniocerebral injuries.